Multiple Chemical Sensitivity: It’s a Brain Problem

Multiple chemical sensitivity (MCS), has long been thought of as a liver disorder. While there is evidence of decreased clearance of harmful metabolites, the majority of new literature is focusing on the brain as being the primary instigator and propagating factor of this illness. In today’s broadcast we will highlight some of the new research coming out on MCS and how this may translate into new therapies for this disorder.

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1.[Environmental medical syndromes].
Wiesmüller GA, Hornberg C.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Jun;60(6):597-604. doi: 10.1007/s00103-017-2546-5. Review. German.
PMID: 28447135 [PubMed – in process]
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2.Multiple chemical sensitivity: Genotypic characterization, nutritional status and quality of life in 52 patients.
Loria-Kohen V, Marcos-Pasero H, de la Iglesia R, Aguilar-Aguilar E, Espinosa-Salinas I, Herranz J, Ramírez de Molina A, Reglero G.
Med Clin (Barc). 2017 Mar 7. pii: S0025-7753(17)30093-3. doi: 10.1016/j.medcli.2017.01.022. [Epub ahead of print] English, Spanish.
PMID: 28283271 [PubMed – as supplied by publisher]
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3.Association of Odor Thresholds and Responses in Cerebral Blood Flow of the Prefrontal Area during Olfactory Stimulation in Patients with Multiple Chemical Sensitivity.
Azuma K, Uchiyama I, Tanigawa M, Bamba I, Azuma M, Takano H, Yoshikawa T, Sakabe K.
PLoS One. 2016 Dec 9;11(12):e0168006. doi: 10.1371/journal.pone.0168006. eCollection 2016.
PMID: 27936122 [PubMed – in process] Free PMC Article
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4.A randomised, placebo-controlled trial of transcranial pulsed electromagnetic fields in patients with multiple chemical sensitivity.
Tran MT, Skovbjerg S, Arendt-Nielsen L, Christensen KB, Elberling J.
Acta Neuropsychiatr. 2016 Dec 6:1-11. [Epub ahead of print]
PMID: 27919300 [PubMed – as supplied by publisher]
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5.Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity.
Viziano A, Micarelli A, Alessandrini M.
Int Arch Occup Environ Health. 2017 Feb;90(2):189-196. doi: 10.1007/s00420-016-1185-8. Epub 2016 Nov 12.
PMID: 27838888 [PubMed – in process]
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6.Lack of contralateral suppression in transient-evoked otoacoustic emissions in multiple chemical sensitivity: a clinical correlation study.
Micarelli A, Viziano A, Genovesi G, Bruno E, Ottaviani F, Alessandrini M.
Noise Health. 2016 May-Jun;18(82):143-9. doi: 10.4103/1463-1741.181997.
PMID: 27157687 [PubMed – indexed for MEDLINE] Free PMC Article
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7.[Application of Metabolomics to Multiple Chemical Sensitivity Research].
Katoh T, Fujiwara Y, Nakashita C, Lu X, Hisada A, Miyazaki W, Azuma K, Tanigawa M, Uchiyama I, Kunugita N.
Nihon Eiseigaku Zasshi. 2016;71(1):94-9. doi: 10.1265/jjh.71.94. Japanese.
PMID: 26832623 [PubMed – indexed for MEDLINE] Free Article
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8.Vestibular impairment in Multiple Chemical Sensitivity: Component analysis findings.
Micarelli A, Viziano A, Bruno E, Micarelli E, Alessandrini M.
J Vestib Res. 2016;26(5-6):459-468. doi: 10.3233/VES-160594.
PMID: 28262643 [PubMed – in process]
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9.Reliable disease biomarkers characterizing and identifying electrohypersensitivity and multiple chemical sensitivity as two etiopathogenic aspects of a unique pathological disorder.
Belpomme D, Campagnac C, Irigaray P.
Rev Environ Health. 2015;30(4):251-71. doi: 10.1515/reveh-2015-0027.
PMID: 26613326 [PubMed – indexed for MEDLINE]
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10.Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity.
Dantoft TM, Skovbjerg S, Andersson L, Claeson AS, Lind N, Nordin S, Brix S.
PLoS One. 2015 Nov 23;10(11):e0143534. doi: 10.1371/journal.pone.0143534. eCollection 2015.
PMID: 26599866 [PubMed – indexed for MEDLINE] Free PMC Article
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11.In-situ Real-Time Monitoring of Volatile Organic Compound Exposure and Heart Rate Variability for Patients with Multiple Chemical Sensitivity.
Mizukoshi A, Kumagai K, Yamamoto N, Noguchi M, Yoshiuchi K, Kumano H, Sakabe K, Yanagisawa Y.
Int J Environ Res Public Health. 2015 Oct 5;12(10):12446-65. doi: 10.3390/ijerph121012446.
PMID: 26445055 [PubMed – indexed for MEDLINE] Free PMC Article
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12.Involvement of Subcortical Brain Structures During Olfactory Stimulation in Multiple Chemical Sensitivity.
Alessandrini M, Micarelli A, Chiaravalloti A, Bruno E, Danieli R, Pierantozzi M, Genovesi G, Öberg J, Pagani M, Schillaci O.
Brain Topogr. 2016 Mar;29(2):243-52. doi: 10.1007/s10548-015-0453-3. Epub 2015 Oct 5.
PMID: 26438099 [PubMed – indexed for MEDLINE]
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  1. So if it is a brain problem then what can we do about it .
    I was an manicurist for 28 years an then I was always stressed out an had a a lot of trama happen to me as i was growning up .. my daughyer tokd me in was from all thee above .. I would to have my life back .. waiting for a cure . Rb

  2. The biggest problem with chronic conditions such as MCS is that there is no one answer that can be given. Each patient is different and needs to be evaluated and treated as such. If you would like to setup a consultation to see if we might be able to help please go to for more information.

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