Diabetes, is it a Gastrointestinal Illness?

In today’s broadcast will be discussing some of the new literature associating diabetes as being an intestinal problem or having very strong connections to the intestines.

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1.Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.
Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM.
Diabetologia. 2015 Oct;58(10):2424-34. doi: 10.1007/s00125-015-3692-7. Epub 2015 Jul 23.
PMID: 26201685 [PubMed – indexed for MEDLINE]
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2.Can targeting ANGPTL proteins improve glucose tolerance?
Davies BSJ.
Diabetologia. 2018 Apr 4. doi: 10.1007/s00125-018-4604-4. [Epub ahead of print]
PMID: 29619530 [PubMed – as supplied by publisher]
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3.Aberrant intestinal microbiota in individuals with prediabetes.
Allin KH, Tremaroli V, Caesar R, Jensen BAH, Damgaard MTF, Bahl MI, Licht TR, Hansen TH, Nielsen T, Dantoft TM, Linneberg A, Jørgensen T, Vestergaard H, Kristiansen K, Franks PW; IMI-DIRECT consortium, Hansen T, Bäckhed F, Pedersen O.
Diabetologia. 2018 Apr;61(4):810-820. doi: 10.1007/s00125-018-4550-1. Epub 2018 Jan 29.
PMID: 29379988 [PubMed – in process]
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4.Arctic berry extracts target the gut-liver axis to alleviate metabolic endotoxaemia, insulin resistance and hepatic steatosis in diet-induced obese mice.
Anhê FF, Varin TV, Le Barz M, Pilon G, Dudonné S, Trottier J, St-Pierre P, Harris CS, Lucas M, Lemire M, Dewailly É, Barbier O, Desjardins Y, Roy D, Marette A.
Diabetologia. 2018 Apr;61(4):919-931. doi: 10.1007/s00125-017-4520-z. Epub 2017 Dec 21.
PMID: 29270816 [PubMed – in process]
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5.Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota.
Janssen AWF, Katiraei S, Bartosinska B, Eberhard D, Willems van Dijk K, Kersten S.
Diabetologia. 2018 Mar 3. doi: 10.1007/s00125-018-4583-5. [Epub ahead of print]
PMID: 29502266 [PubMed – as supplied by publisher]
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  1. Hi Dr. Gates and Dr. Rutherford, thanks for the info! Question, for diabetes, would you start the patient on the autoimmune paleo diet? I know it probably depends on the patient’s history as you stated in your diet video, but I live in a pretty poor area where doctors don’t focus on diets. I don’t have diabetes but my mom does. I have hashimotos and will be doing the modified Paleo diet and wondered if it will benefit my mom too.

  2. It would definitely be a good diet to try out. We have seen how important a clean diet can be to helping to regulate blood sugar for many of our diabetic patients so it would be worth a shot!

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