Hashimoto’s Thyroiditis: Is Your Thyroid Problem Really An Immune System Problem?

Today we are discussing Hashimoto’s Thyroiditis.  Over the years scores of thyroid patients have presented to our clinic with persistent thyroid symptoms though they were on thyroid medication.  We have been taught as a society that symptoms of symptoms of hypothyroidism or hyperthyroidism are due to thyroid gland dysfunction.  While this is correct, the underlying cause of the thyroid dysfunction, the immune system, has received little attention. In today’s broadcast we will be discussing why your immune system likely the missing link for those who have persistent “thyroid symptoms” while still on appropriate medication therapy.
Please forward us any comments here on our website or go to our Power Health Facebook page http://powerhealthreno.com/Facebook
References:
1. Regulatory B and T cell responses in patients with autoimmune thyroid disease and healthy controls.
Kristensen B.
Dan Med J. 2016 Feb;63(2). pii: B5177.
PMID: 26836805 [PubMed – in process]
Similar articles
2. Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy.
Ilias I, Karagiorga V, Paraskevas G, Bougea A, Bourbouli M, Pappa A, Nikopoulou S, Kapaki E.
J Thyroid Res. 2015;2015:819072. doi: 10.1155/2015/819072. Epub 2015 Dec 21.
PMID: 26798549 [PubMed] Free PMC Article
Similar articles
3. Initial serum thyroid peroxidase antibodies and long-term outcomes in SREAT.
Litmeier S, Prüss H, Witsch E, Witsch J.
Acta Neurol Scand. 2016 Jan 12. doi: 10.1111/ane.12556. [Epub ahead of print]
PMID: 26757046 [PubMed – as supplied by publisher]
Similar articles
4. Evaluation of Xerostomia and salivary flow rate in Hashimoto’s Thyroiditis.
Agha-Hosseini F, Shirzad N, Moosavi MS.
Med Oral Patol Oral Cir Bucal. 2016 Jan 1;21(1):e1-5.
PMID: 26595829 [PubMed – in process] Free PMC Article
Similar articles
5. Technetium-99m thyroid scan; does it have a diagnostic aid in sub-clinical auto-immune thyroid disease in systemic lupus erythematosus patients?
Amin A, Alkemary A, Abdo M, Salama M.
Lupus. 2016 Feb;25(2):155-61. doi: 10.1177/0961203315603137. Epub 2015 Sep 7.
PMID: 26345676 [PubMed – in process]
Similar articles
6. Thyroid dysfunction: an autoimmune aspect.
Khan FA, Al-Jameil N, Khan MF, Al-Rashid M, Tabassum H.
Int J Clin Exp Med. 2015 May 15;8(5):6677-81. eCollection 2015. Review.
PMID: 26221205 [PubMed] Free PMC Article
Similar articles
7. Insulin resistance in hypothyroid patients under Levothyroxine therapy: a comparison between those with and without thyroid autoimmunity.
Mazaheri T, Sharifi F, Kamali K.
J Diabetes Metab Disord. 2014 Oct 30;13(1):103. doi: 10.1186/s40200-014-0103-4. eCollection 2014.
PMID: 25364704 [PubMed] Free PMC Article
Similar articles
8. Immunological Characteristics of Children with Hashimoto’s Autoimmune Thyroiditis.
Kucharska AM, Gorska E, Stelmaszczyk-Emmel A, Demkow U, Pyr?ak B.
Adv Exp Med Biol. 2015;833:47-53. doi: 10.1007/5584_2014_35.
PMID: 25248347 [PubMed – indexed for MEDLINE]
Similar articles
9. Connective tissue diseases and autoimmune thyroid disorders in the first trimester of pregnancy.
Beneventi F, Locatelli E, Caporali R, Alpini C, Lovati E, Ramoni V, Simonetta M, Cavagnoli C, Montecucco C, Spinillo A.
J Reprod Immunol. 2016 Mar 2;114:32-37. doi: 10.1016/j.jri.2016.02.004. [Epub ahead of print]
PMID: 26950897 [PubMed – as supplied by publisher]
Similar articles
10. Cerebellar ataxia as presenting feature of hypothyroidism.
Kotwal SK, Kotwal S, Gupta R, Singh JB, Mahajan A.
Arch Endocrinol Metab. 2016 Feb 16. pii: S2359-39972016005001105. [Epub ahead of print]
PMID: 26886095 [PubMed – as supplied by publisher] Free Article
Similar articles
11. The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus.
Rasaei N, Shams M, Kamali-Sarvestani E, Nazarinia MA.
Iran Red Crescent Med J. 2015 Dec 5;17(12):e17298. doi: 10.5812/ircmj.17298. eCollection 2015 Dec.
PMID: 26756002 [PubMed] Free PMC Article
Similar articles
12. Is vitamin D related to pathogenesis and treatment of Hashimoto’s thyroiditis?
Mazokopakis EE, Papadomanolaki MG, Tsekouras KC, Evangelopoulos AD, Kotsiris DA, Tzortzinis AA.
Hell J Nucl Med. 2015 Sep-Dec;18(3):222-7.
PMID: 26637501 [PubMed – indexed for MEDLINE] Free Article
Similar articles
13. Clinical and imaging characteristics of 16 patients with autoimmune neuronal synaptic encephalitis.
Kamble N, Netravathi M, Saini J, Mahadevan A, Yadav R, Nalini A, Pal PK, Satishchandra P.
Neurol India. 2015 Sep-Oct;63(5):687-96. doi: 10.4103/0028-3886.166532.
PMID: 26448226 [PubMed – in process] Free Article
Similar articles
14. Functional status of thyroid and cognitive functions after menopause.
Bojar I, Owoc A, Gujski M, Witczak M, Gnatowski M, Walecka I.
Med Sci Monit. 2015 Jun 4;21:1625-33. doi: 10.12659/MSM.892880.
PMID: 26042394 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
15. Hashimoto’s encephalopathy and motor neuron disease: a common autoimmune pathogenesis?
Harzheim M, Feucht J, Pauleit D, Pöhlau D.
Neurol India. 2006 Sep;54(3):301-3.
PMID: 16936396 [PubMed – indexed for MEDLINE] Free Article
Similar articles
16. Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients.
Degner D, Haust M, Meller J, Rüther E, Reulbach U.
Eur Arch Psychiatry Clin Neurosci. 2015 Feb;265(1):67-72. doi: 10.1007/s00406-014-0529-1. Epub 2014 Sep 6.
PMID: 25193677 [PubMed – indexed for MEDLINE]
Similar articles
17. Positive thyroid peroxidase antibody titer is associated with dysphoric moods during pregnancy and postpartum.
Groer MW, Vaughan JH.
J Obstet Gynecol Neonatal Nurs. 2013 Jan-Feb;42(1):E26-32. doi: 10.1111/j.1552-6909.2012.01425.x. Epub 2012 Nov 20.
PMID: 23167615 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
18. Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 British birth cohort study.
Ong KK, Kuh D, Pierce M, Franklyn JA; Medical Research Council National Survey of Health and Development Scientific and Data Collection Teams.
J Clin Endocrinol Metab. 2013 Apr;98(4):1435-42. doi: 10.1210/jc.2012-3761. Epub 2013 Feb 22.
PMID: 23436917 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
19. The thyroid and the gut.
Ebert EC.
J Clin Gastroenterol. 2010 Jul;44(6):402-6. doi: 10.1097/MCG.0b013e3181d6bc3e. Review.
PMID: 20351569 [PubMed – indexed for MEDLINE]
Similar articles
20. Mean platelet volume in euthyroid patients with Hashimoto’s thyroiditis.
Carlioglu A, Timur O, Durmaz SA, Ayhan ME.
Blood Coagul Fibrinolysis. 2015 Apr;26(3):282-4. doi: 10.1097/MBC.0000000000000236.
PMID: 25485785 [PubMed – indexed for MEDLINE]
Similar articles
21. Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study).
Vissenberg R, van Dijk MM, Fliers E, van der Post JA, van Wely M, Bloemenkamp KW, Hoek A, Kuchenbecker WK, H R Verhoeve, H C J Scheepers, Rombout-de Weerd S, Koks C, Zwart JJ, Broekmans F, Verpoest W, Christiansen O, M Post, Papatsonis DN, Verberg MF, Sikkema J, Mol BW, Bisschop PH, Goddijn M.
Contemp Clin Trials. 2015 Aug 5. pii: S1551-7144(15)30061-6. doi: 10.1016/j.cct.2015.08.005. [Epub ahead of print]
PMID: 26255238 [PubMed – as supplied by publisher]
Similar articles
22. Anti-TPO antibodies diffusion through the placental barrier during pregnancy.
Seror J, Amand G, Guibourdenche J, Ceccaldi PF, Luton D.
PLoS One. 2014 Jan 31;9(1):e84647. doi: 10.1371/journal.pone.0084647. eCollection 2014.
PMID: 24497920 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
23. Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity preconception and in pregnancy.
Chan S, Boelaert K.
Clin Endocrinol (Oxf). 2015 Mar;82(3):313-26. doi: 10.1111/cen.12605. Epub 2014 Oct 28. Review.
PMID: 25200555 [PubMed – indexed for MEDLINE]
Similar articles
24. [Comparison of the effect of different diagnostic criteria of subclinical hypothyroidism and positive TPO-Ab on pregnancy outcomes].
He Y, He T, Wang Y, Xu Z, Xu Y, Wu Y, Ji J, Mi Y.
Zhonghua Fu Chan Ke Za Zhi. 2014 Nov;49(11):824-8. Chinese.
PMID: 25603906 [PubMed – indexed for MEDLINE]
Similar articles
25. A new type of natural bispecific antibody with potential protective effect in Hashimoto thyroiditis.
Li W, Fan G, Chen L, Zhang R, Zhang K, Sun Y, Lin G, Xie J, Wang L, Li J.
J Clin Endocrinol Metab. 2014 Sep;99(9):E1602-9. doi: 10.1210/jc.2013-4108. Epub 2014 Jun 6.
PMID: 24905062 [PubMed – indexed for MEDLINE]
Similar articles
26. Cognitive and affective dysfunctions in autoimmune thyroiditis.
Leyhe T, Müssig K.
Brain Behav Immun. 2014 Oct;41:261-6. doi: 10.1016/j.bbi.2014.03.008. Epub 2014 Mar 29. Review.
PMID: 24685840 [PubMed – indexed for MEDLINE]
Similar articles
27. Treatment of recurrent pregnancy loss by Levothyroxine in women with high Anti-TPO antibody.
Mosaddegh MH, Ghasemi N, Jahaninejad T, Mohsenifar F, Aflatoonian A.
Iran J Reprod Med. 2012 Jul;10(4):373-6.
PMID: 25246900 [PubMed] Free PMC Article
Similar articles
28. Thyroid function and prevalence of anti-thyroperoxidase (TPO) and anti-thyroglobulin (Tg) antibodies in outpatients hospital setting in an area with sufficient iodine intake: influences of age and sex.
Legakis I, Manousaki M, Detsi S, Nikita D.
Acta Med Iran. 2013;51(1):25-34.
PMID: 23456581 [PubMed – indexed for MEDLINE] Free Article
Similar articles
29. Is there a link between Hashimoto’s thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti-TPO antibodies in 2267 patients.
Ignjatovic VD, Matovic MD, Vukomanovic VR, Jankovic SM, Džodi? RR.
Hell J Nucl Med. 2013 May-Aug;16(2):86-90.
PMID: 23865082 [PubMed – indexed for MEDLINE] Free Article
Similar articles
30. Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies.
Vissenberg R, Fliers E, van der Post JA, van Wely M, Bisschop PH, Goddijn M.
Gynecol Endocrinol. 2016 Feb;32(2):132-5. doi: 10.3109/09513590.2015.1092513. Epub 2015 Oct 2.
PMID: 26430806 [PubMed – in process]
Similar articles
31. [Case of anti-TPO/gliadin antibody-positive cerebellar atrophy that responded to intravenous immunoglobulin therapy begun 16 years after onset].
Tanaka N, Otake H, Ito S, Niiyama K, Nanri K.
Rinsho Shinkeigaku. 2012;52(5):351-5. Japanese.
PMID: 22688115 [PubMed – indexed for MEDLINE]
Similar articles
32. Positivity rates of antithyroid antibody, antinuclear antibody and thyroid peroxidase antibody in different types of vitiligo.
Lim HK, Bae MI, Jeong KH, Shin MK, Lee MH.
Clin Exp Dermatol. 2016 Apr;41(3):242-7. doi: 10.1111/ced.12771. Epub 2015 Oct 9.
PMID: 26452586 [PubMed – in process]
Similar articles
33. Prevalence of anti-Neu5Gc antibodies in patients with hypothyroidism.
Eleftheriou P, Kynigopoulos S, Giovou A, Mazmanidi A, Yovos J, Skepastianos P, Vagdatli E, Petrou C, Papara D, Efterpiou M.
Biomed Res Int. 2014;2014:963230. doi: 10.1155/2014/963230. Epub 2014 Jun 9.
PMID: 25003133 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
34. Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life.
Bhattacharyya R, Mukherjee K, Das A, Biswas MR, Basunia SR, Mukherjee A.
J Nat Sci Biol Med. 2015 Jul-Dec;6(2):402-5. doi: 10.4103/0976-9668.160021.
PMID: 26283839 [PubMed] Free PMC Article
Similar articles
35. Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria.
Shin YS, Suh DH, Yang EM, Ye YM, Park HS.
J Korean Med Sci. 2015 Jun;30(6):705-9. doi: 10.3346/jkms.2015.30.6.705. Epub 2015 May 13.
PMID: 26028921 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
36. Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies.
Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, Köhrle J, Wiersinga WM.
Clin Endocrinol (Oxf). 2014 Mar;80(3):444-51. doi: 10.1111/cen.12284. Epub 2013 Jul 31.
PMID: 23844613 [PubMed – indexed for MEDLINE]
Similar articles
37. Glutamic acid decarboxylase (anti-GAD) & tissue transglutaminase (anti-TTG) antibodies in patients with thyroid autoimmunity.
Marwaha RK, Garg MK, Tandon N, Kanwar R, Narang A, Sastry A, Saberwal A, Bhadra K.
Indian J Med Res. 2013 Jan;137(1):82-6.
PMID: 23481055 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
38. Male gender differences in the thyroid ultrasound features, thyroid peroxidase antibodies and thyroid hormone levels: a large population-based study.
Shinkov A, Borissova AM, Vlahov J, Dakovska L, Blajeva E.
J Endocrinol Invest. 2014 Mar;37(3):269-76. doi: 10.1007/s40618-013-0024-y. Epub 2014 Jan 9.
PMID: 24615363 [PubMed – indexed for MEDLINE]
Similar articles
39. Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort.
Brown AS, Surcel HM, Hinkka-Yli-Salomäki S, Cheslack-Postava K, Bao Y, Sourander A.
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:86-92. doi: 10.1016/j.pnpbp.2014.10.010. Epub 2014 Oct 29.
PMID: 25445476 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
40. Serum thyroid-stimulating hormone and anti-thyroglobulin antibody are independently associated with lesions in spinal cord in central nervous system demyelinating diseases.
Long Y, Zheng Y, Chen M, Zhang B, Gao C, Shan F, Yang N, Fan Y.
PLoS One. 2014 Aug 5;9(8):e100672. doi: 10.1371/journal.pone.0100672. eCollection 2014.
PMID: 25093326 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles

2 Comments

  1. For Dr Rutherford
    When I first interviewed with you over 3 years ago ( holy cow, time flys, even when you are not having fun)
    I asked then if the Hashimotos that you diagnosed was reversible. 3 years ago, you said it was not. Has anything changed in that 3 years?
    BTW, I am maniacal about following your recommended diet and lifestyle and I feel 99 percent normal. I still have some allergic side effects with the small doses of what we found I am allergic to, but they are almost negligible compared to how sick I was 3 years ago. Like I used to be in bed for 2 days at a time sick, and now I go all day and barely notice being off center occasionally. My immune system apparently is getting better. Dr gates cautioned me that it might take over a year for those mast cells to retrain themselves.
    I am learning the hard way that some corn and soy is hidden in foods and vitamins, like corn in my Vit D supplement.
    Thank you so much for all this work and research. I have friends who are going thru the hoops with all their different doctors and I keep telling them to see you now, but they carry on in another direction and are still sick. I realize that everyone has to go thru their own paces. I feel fortunate that I STARTED with you, rather than end up with you(se) guys.
    Healthy hugs to both of you.

  2. DEAR DRS. SUPER INTERESTING AND I LEARNED INFORMATION FROM YOU THAT I CAN HELP TWO FAMILY MEMBERS AND SOME OF MY FRIENDS AS WELL. THANKS FOR ALL THE EXTENSIVE RESEARCH AND MOST OF ALL THE CARING THAT THE TWO OF YOU PRESENT TO YOUR PATIENTS AND EVEN THE PUBLIC BY ALL YOU SHARE.

Leave a Comment

Your email address will not be published. Required fields are marked *

*

This site uses Akismet to reduce spam. Learn how your comment data is processed.