Understanding TH1 and TH2 Responses for the Autoimmune Patient

Today we will be discussing cytokines as part of our discussion on autoimmune diseases. We find the most patients do not have a good understanding of this issue, so today we are going to explore it in more detail, and What it may mean to your autoimmune illness.

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1.Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of ankylosing spondylitis.
Wen JT, Zhang DH, Fang PF, Li MH, Wang RJ, Li SH.
Genet Mol Res. 2017 Mar 16;16(1). doi: 10.4238/gmr16019322.
PMID: 28362980 [PubMed – indexed for MEDLINE]
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2.Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis.
van Hamburg JP, Tas SW.
J Autoimmun. 2017 Dec 15. pii: S0896-8411(17)30801-6. doi: 10.1016/j.jaut.2017.12.006. [Epub ahead of print] Review.
PMID: 29254845 [PubMed – as supplied by publisher] Free Article
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3.A cellular and molecular view of T helper 17 cell plasticity in autoimmunity.
Stadhouders R, Lubberts E, Hendriks RW.
J Autoimmun. 2017 Dec 21. pii: S0896-8411(17)30803-X. doi: 10.1016/j.jaut.2017.12.007. [Epub ahead of print] Review.
PMID: 29275836 [PubMed – as supplied by publisher] Free Article
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4.Involvement of the IL-23/IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune arthritis.
Astry B, Venkatesha SH, Moudgil KD.
Cytokine. 2015 Jul;74(1):54-61. doi: 10.1016/j.cyto.2014.11.020. Epub 2015 Jan 13.
PMID: 25595306 [PubMed – indexed for MEDLINE] Free PMC Article
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5.CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.
Hirahara K, Nakayama T.
Int Immunol. 2016 Apr;28(4):163-71. doi: 10.1093/intimm/dxw006. Epub 2016 Feb 12. Review.
PMID: 26874355 [PubMed – indexed for MEDLINE] Free PMC Article
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6.Pathogenic Th cell subsets in chronic inflammatory diseases.
Kumagai J, Hirahara K, Nakayama T.
Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(2):114-23. doi: 10.2177/jsci.39.114. Review. Japanese.
PMID: 27212597 [PubMed – indexed for MEDLINE] Free Article
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7.Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-?+IL-17+coproducing CD4+ T cells in active inflammatory bowel disease.
Globig AM, Hennecke N, Martin B, Seidl M, Ruf G, Hasselblatt P, Thimme R, Bengsch B.
Inflamm Bowel Dis. 2014 Dec;20(12):2321-9. doi: 10.1097/MIB.0000000000000210.
PMID: 25248005 [PubMed – indexed for MEDLINE]
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