The Chronic Pain Epidemic: Is the Brain to Blame?

Today we will be discussing the chronic pain epidemic, which for all intents and purposes is becoming a tsunami for our health care system.  The paradigm for treating chronic pain patients has been to alleviate the problem in the affected joint.  The classic examples of this include applying massage, physical therapy, chiropractic, medications, and ultimately surgery if necessary to the affected body region to help with the pain. Though these modalities absolutely have their place and can be very effective for acute pain, often they become less effective in the arena of chronic pain.

In today’s broadcast we will highlight why this happens, and how we have to shift our paradigm relative to chronic pain.  We propose that the most effective paradigm for chronic pain sufferers who have failed the traditional route, is a brain centered approach.

Please forward us any comments here on our website or go to our Power Health Facebook page
1.Sleep is associated with task-negative brain activity in fibromyalgia participants with comorbid chronic insomnia.
Vatthauer KE, Craggs JG, Robinson ME, Staud R, Berry RB, Perlstein WM, McCrae CS.
J Pain Res. 2015 Nov 12;8:819-27. doi: 10.2147/JPR.S87501. eCollection 2015.
PMID: 26648751 [PubMed] Free PMC Article
Similar articles
2.Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea.
Wei SY, Chao HT, Tu CH, Li WC, Low I, Chuang CY, Chen LF, Hsieh JC.
Pain. 2016 Jan;157(1):92-102. doi: 10.1097/j.pain.0000000000000340.
PMID: 26307856 [PubMed – in process]
Similar articles
3.Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.
Kim H, Kim J, Loggia ML, Cahalan C, Garcia RG, Vangel MG, Wasan AD, Edwards RR, Napadow V.
Neuroimage Clin. 2015 Mar 4;7:667-77. doi: 10.1016/j.nicl.2015.02.022. eCollection 2015.
PMID: 25844321 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
4.Resting state connectivity correlates with drug and placebo response in fibromyalgia patients.
Schmidt-Wilcke T, Ichesco E, Hampson JP, Kairys A, Peltier S, Harte S, Clauw DJ, Harris RE.
Neuroimage Clin. 2014 Sep 16;6:252-61. doi: 10.1016/j.nicl.2014.09.007. eCollection 2014.
PMID: 25379438 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
5.Fibromyalgia is associated with decreased connectivity between pain- and sensorimotor brain areas.
Flodin P, Martinsen S, Löfgren M, Bileviciute-Ljungar I, Kosek E, Fransson P.
Brain Connect. 2014 Oct;4(8):587-94. doi: 10.1089/brain.2014.0274. Epub 2014 Aug 7.
PMID: 24998297 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
6.The contribution of sensory system functional connectivity reduction to clinical pain in fibromyalgia.
Pujol J, Macià D, Garcia-Fontanals A, Blanco-Hinojo L, López-Solà M, Garcia-Blanco S, Poca-Dias V, Harrison BJ, Contreras-Rodríguez O, Monfort J, Garcia-Fructuoso F, Deus J.
Pain. 2014 Aug;155(8):1492-503. doi: 10.1016/j.pain.2014.04.028. Epub 2014 May 2.
PMID: 24792477 [PubMed – indexed for MEDLINE]
Similar articles
7.Ipsilateral cortical activation in fibromyalgia patients during brushing correlates with symptom severity.
Fallon N, Chiu YH, Li X, Nurmikko TJ, Stancak A.
Clin Neurophysiol. 2013 Jan;124(1):154-63. doi: 10.1016/j.clinph.2012.06.014. Epub 2012 Jul 21.
PMID: 22819596 [PubMed – indexed for MEDLINE]
Similar articles
8.Brain activations during pain: a neuroimaging meta-analysis of pain patients and healthy controls.
Jensen KB, Regenbogen C, Ohse MC, Frasnelli J, Freiherr J, Lundström JN.
Pain. 2016 Feb 11. [Epub ahead of print]
PMID: 26871535 [PubMed – as supplied by publisher]
Similar articles
9.Neurocognitive and Neuroplastic Mechanisms of Novel Clinical Signs in CRPS.
Kuttikat A, Noreika V, Shenker N, Chennu S, Bekinschtein T, Brown CA.
Front Hum Neurosci. 2016 Jan 27;10:16. doi: 10.3389/fnhum.2016.00016. eCollection 2016. Review.
PMID: 26858626 [PubMed] Free PMC Article
Similar articles
10.Increasing Neuroplasticity to Bolster Chronic Pain Treatment: A Role for Intermittent Fasting and Glucose Administration?
Sibille KT, Bartsch F, Reddy D, Fillingim RB, Keil A.
J Pain. 2016 Feb 1. pii: S1526-5900(15)00946-3. doi: 10.1016/j.jpain.2015.11.002. [Epub ahead of print]
PMID: 26848123 [PubMed – as supplied by publisher]
Similar articles
11.Abnormal Subcortical Brain Morphology in Patients with Knee Osteoarthritis: A Cross-sectional Study.
Mao CP, Bai ZL, Zhang XN, Zhang QJ, Zhang L.
Front Aging Neurosci. 2016 Jan 19;8:3. doi: 10.3389/fnagi.2016.00003. eCollection 2016.
PMID: 26834629 [PubMed] Free PMC Article
Similar articles
12.Fear and Reward Circuit Alterations in Pediatric CRPS.
Simons LE, Erpelding N, Hernandez JM, Serrano P, Zhang K, Lebel AA, Sethna NF, Berde CB, Prabhu SP, Becerra L, Borsook D.
Front Hum Neurosci. 2016 Jan 19;9:703. doi: 10.3389/fnhum.2015.00703. eCollection 2015.
PMID: 26834606 [PubMed] Free PMC Article
Similar articles
13.Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells.
Massart R, Dymov S, Millecamps M, Suderman M, Gregoire S, Koenigs K, Alvarado S, Tajerian M, Stone LS, Szyf M.
Sci Rep. 2016 Jan 28;6:19615. doi: 10.1038/srep19615.
PMID: 26817950 [PubMed – in process] Free PMC Article
Similar articles
14.Alterations in Gray Matter Volume are Associated with Reduced Evoked-Pain Connectivity following Acute Pregabalin Administration.
Puiu T, Kairys AE, Pauer L, Schmidt-Wilcke T, Ichesco E, Hampson JP, Napadow V, Clauw DJ, Harris RE.
Arthritis Rheumatol. 2016 Jan 27. doi: 10.1002/art.39600. [Epub ahead of print]
PMID: 26816332 [PubMed – as supplied by publisher]
Similar articles
15.Fibromyalgia and Bipolar Disorder: Emerging Epidemiological Associations and Shared Pathophysiology.
Bortolato B, Berk M, Maes M, McIntyre RS, Carvalho AF.
Curr Mol Med. 2016;16(2):119-36.
PMID: 26812920 [PubMed – in process]
Similar articles
16.Neural circuit remodeling and structural plasticity in the cortex during chronic pain.
Kim W, Kim SK.
Korean J Physiol Pharmacol. 2016 Jan;20(1):1-8. doi: 10.4196/kjpp.2016.20.1.1. Epub 2015 Dec 31. Review.
PMID: 26807017 [PubMed] Free PMC Article
Similar articles
17.Neuroplastic Effects of Transcranial Direct Current Stimulation on Painful Symptoms Reduction in Chronic Hepatitis C: A Phase II Randomized, Double Blind, Sham Controlled Trial.
Brietzke AP, Rozisky JR, Dussan-Sarria JA, Deitos A, Laste G, Hoppe PF, Muller S, Torres IL, Alvares-da-Silva MR, de Amorim RF, Fregni F, Caumo W.
Front Neurosci. 2016 Jan 11;9:498. doi: 10.3389/fnins.2015.00498. eCollection 2015.
PMID: 26793047 [PubMed] Free PMC Article
Similar articles

Leave a Comment

Your email address will not be published. Required fields are marked *