TBI and Post-Concussion Syndrome: Look to the Gut and the Mitochondria


Today we will be discussing Traumatic Brain Injury and PCS and factors perpetuating symptoms of the head injury.  Today we will focus particularly on how gastrointestinal barrier integrity is compromised as well as how the mitochondria (considered the powerhouse of our cells that generate cellular energy) are negatively affected by brain injury.
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1.Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review.
Asken BM, Sullan MJ, Snyder AR, Houck ZM, Bryant VE, Hizel LP, McLaren ME, Dede DE, Jaffee MS, DeKosky ST, Bauer RM.
Neuropsychol Rev. 2016 Aug 25. [Epub ahead of print] Review.
PMID: 27561662 [PubMed – as supplied by publisher]
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2.Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury.
Dong T, Zhi L, Bhayana B, Wu MX.
J Neuroinflammation. 2016 Aug 25;13(1):197. doi: 10.1186/s12974-016-0663-y.
PMID: 27561600 [PubMed – in process]
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3.Patients “At Risk” of Suffering from Persistent Complaints after Mild Traumatic Brain Injury: The Role of Coping, Mood Disorders, and Post-Traumatic Stress.
Scheenen ME, Spikman JM, de Koning ME, van der Horn HJ, Roks G, Hageman G, van der Naalt J.
J Neurotrauma. 2016 Aug 25. [Epub ahead of print]
PMID: 27560623 [PubMed – as supplied by publisher]
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4.Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterations.
Chen H, Chan YL, Nguyen LT, Mao Y, De Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C.
Clin Exp Pharmacol Physiol. 2016 Aug 25. doi: 10.1111/1440-1681.12650. [Epub ahead of print]
PMID: 27557565 [PubMed – as supplied by publisher]
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5.Systems Biology, Neuroimaging, Neuropsychology, Neuroconnectivity and Traumatic Brain Injury.
Bigler ED.
Front Syst Neurosci. 2016 Aug 9;10:55. doi: 10.3389/fnsys.2016.00055. eCollection 2016.
PMID: 27555810 [PubMed] Free PMC Article
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6.Combat blast related traumatic brain injury (TBI): Decade of recognition; promise of progress.
DePalma RG, Hoffman SW.
Behav Brain Res. 2016 Aug 20. pii: S0166-4328(16)30553-8. doi: 10.1016/j.bbr.2016.08.036. [Epub ahead of print]
PMID: 27555540 [PubMed – as supplied by publisher]
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7.Treatment of surgical brain injury by immune tolerance induced by intrathymic and hepatic portal vein injection of brain antigens.
Yang W, Liu Y, Liu B, Tan H, Lu H, Wang H, Yan H.
Sci Rep. 2016 Aug 24;6:32030. doi: 10.1038/srep32030.
PMID: 27554621 [PubMed – in process] Free Article
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8.Cerebral Perfusion changes in Post-Concussion Syndrome: A prospective controlled cohort study.
Barlow K, Marcil LD, Carlson HL, Dewey D, MacMaster FP, Brooks BL, Lebel M.
J Neurotrauma. 2016 Aug 23. [Epub ahead of print]
PMID: 27554429 [PubMed – as supplied by publisher]
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9.Post-traumatic administration of the p53 inactivator pifithrin-? oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.
Yang LY, Greig NH, Huang YN, Hsieh TH, Tweedie D, Yu QS, Hoffer BJ, Luo Y, Kao YC, Wang JY.
Neurobiol Dis. 2016 Aug 20. pii: S0969-9961(16)30204-2. doi: 10.1016/j.nbd.2016.08.012. [Epub ahead of print]
PMID: 27553877 [PubMed – as supplied by publisher]
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10.Early prediction of outcome after severe traumatic brain injury: a simple and practical model.
Rizoli S, Petersen A, Bulger E, Coimbra R, Kerby JD, Minei J, Morrison L, Nathens A, Schreiber M, de Oliveira Manoel AL; ROC Investigators.
BMC Emerg Med. 2016 Aug 24;16(1):32. doi: 10.1186/s12873-016-0098-x.
PMID: 27553436 [PubMed – in process] Free PMC Article
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11.Disrupted white matter microstructure and mood disorders following traumatic brain injury.
Spitz G, Alway YJ, Gould K, Ponsford J.
J Neurotrauma. 2016 Aug 22. [Epub ahead of print]
PMID: 27550509 [PubMed – as supplied by publisher]
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12.The gut in trauma.
Patel JJ, Rosenthal MD, Miller KR, Martindale RG.
Curr Opin Crit Care. 2016 Aug;22(4):339-46. doi: 10.1097/MCC.0000000000000331.
PMID: 27314259 [PubMed – in process]
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13.Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production.
Houlden A, Goldrick M, Brough D, Vizi ES, Lénárt N, Martinecz B, Roberts IS, Denes A.
Brain Behav Immun. 2016 Apr 6. pii: S0889-1591(16)30094-0. doi: 10.1016/j.bbi.2016.04.003. [Epub ahead of print]
PMID: 27060191 [PubMed – as supplied by publisher] Free Article
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14.Brain-gut axis and pentadecapeptide BPC 157. Theoretical and practical implications.
Predrag S, Sven S, Rudolf R, Danijela K, Lovorka BV, Domagoj D, Tihomir G, Sanja S, Goran Z, Dalibor C, Goran M, Iva R, Mario S, Marko B, Neven S, Zoran K, Martina LB, Igor F, Dinko SR, Josipa V.
Curr Neuropharmacol. 2016 May 2. [Epub ahead of print]
PMID: 27138887 [PubMed – as supplied by publisher]
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15.Traumatic Brain Injury and the Effect on the Brain-Gut Axis.
Kharrazian D.
Altern Ther Health Med. 2015 Aug;21 Suppl 3:28-32.
PMID: 26348611 [PubMed – in process]
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16.The gut reaction to traumatic brain injury.
Katzenberger RJ, Ganetzky B, Wassarman DA.
Fly (Austin). 2015;9(2):68-74. doi: 10.1080/19336934.2015.1085623.
PMID: 26291482 [PubMed – in process]
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17.Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury.
Lang Y, Fu F, Sun D, Xi C, Chen F.
PLoS One. 2015 Jul 17;10(7):e0133215. doi: 10.1371/journal.pone.0133215. eCollection 2015.
PMID: 26186619 [PubMed – indexed for MEDLINE] Free PMC Article
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18.Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?
Zheng X, Zhang X, Kang A, Ran C, Wang G, Hao H.
Neuropharmacology. 2015 Sep;96(Pt A):94-104. doi: 10.1016/j.neuropharm.2014.06.020. Epub 2014 Jun 28. Review.
PMID: 24978103 [PubMed – indexed for MEDLINE]
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19.Ghrelin attenuates brain injury after traumatic brain injury and uncontrolled hemorrhagic shock in rats.
Qi L, Cui X, Dong W, Barrera R, Nicastro J, Coppa GF, Wang P, Wu R.
Mol Med. 2012 Mar 27;18:186-93. doi: 10.2119/molmed.2011.00390.
PMID: 22160303 [PubMed – indexed for MEDLINE] Free PMC Article
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