Stem Cells and Neurological Disorders: The New Wild West of Neurology

Today we will be discussing new literature regarding stem cells and their efficacy for conditions such as Multiple Sclerosis (M.S.), Amyotrophic Lateral Sclerosis (ALS also known as Lou Gehrig’s Disease), and Stroke.  We will try to present these findings from the perspective of exciting possibilities but also the reality and current expectations of stem cell use.

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1.Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Burman J, Kirgizov K, Carlson K, Badoglio M, Mancardi GL, De Luca G, Casanova B, Ouyang J, Bembeeva R, Haas J, Bader P, Snowden J, Farge D.
Bone Marrow Transplant. 2017 Mar 20. doi: 10.1038/bmt.2017.40. [Epub ahead of print]
PMID: 28319075 [PubMed – as supplied by publisher]
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2.Progress and prospects for the use and the understanding of the mode of action of autologous hematopoietic stem cell transplantation in the treatment of multiple sclerosis.
Collins F, Kazmi M, Muraro PA.
Expert Rev Clin Immunol. 2017 Mar 20:1-12. doi: 10.1080/1744666X.2017.1297232. [Epub ahead of print]
PMID: 28277827 [PubMed – as supplied by publisher]
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3.Intrathecal Injection of Peripherally Mobilized Blood Stem Cells to Treat Multiple Sclerosis.
Hammadi AM, Al-Himyari FA.
Exp Clin Transplant. 2017 Feb;15(Suppl 1):147-149.
PMID: 28260456 [PubMed – in process] Free Article
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4.Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function.
Anderson P, Gonzalez-Rey E, O’Valle F, Martin F, Oliver FJ, Delgado M.
Stem Cells Int. 2017;2017:2389753. doi: 10.1155/2017/2389753.
PMID: 28250776 [PubMed – in process] Free PMC Article
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5.Bone morphogenetic proteins in multiple sclerosis: Role in neuroinflammation.
Eixarch H, Calvo-Barreiro L, Montalban X, Espejo C.
Brain Behav Immun. 2017 Feb 27. pii: S0889-1591(17)30061-2. doi: 10.1016/j.bbi.2017.02.019. [Epub ahead of print] Review.
PMID: 28249802 [PubMed – as supplied by publisher]
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6.Attempts to Overcome Remyelination Failure: Toward Opening New Therapeutic Avenues for Multiple Sclerosis.
Motavaf M, Sadeghizadeh M, Javan M.
Cell Mol Neurobiol. 2017 Feb 21. doi: 10.1007/s10571-017-0472-6. [Epub ahead of print] Review.
PMID: 28224237 [PubMed – as supplied by publisher]
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7.Effect of Fingolimod on Neural Stem Cells: A Novel Mechanism and Broadened Application for Neural Repair.
Zhang Y, Li X, Ciric B, Ma CG, Gran B, Rostami A, Zhang GX.
Mol Ther. 2017 Feb 1;25(2):401-415. doi: 10.1016/j.ymthe.2016.12.008.
PMID: 28153091 [PubMed – in process]
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8.Brain pathology of a patient 7years after autologous hematopoietic stem cell transplantation for multiple sclerosis.
Wundes A, Bowen JD, Kraft GH, Maravilla KR, McLaughlin B, von Geldern G, Georges G, Nash RA, Lu JQ.
J Neurol Sci. 2017 Feb 15;373:339-341. doi: 10.1016/j.jns.2017.01.016.
PMID: 28131217 [PubMed – in process]
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9.Stem cells for ALS: An overview of possible therapeutic approaches.
Czarzasta J, Habich A, Siwek T, Czapli?ski A, Maksymowicz W, Wojtkiewicz J.
Int J Dev Neurosci. 2017 Apr;57:46-55. doi: 10.1016/j.ijdevneu.2017.01.003. Review.
PMID: 28088365 [PubMed – in process]
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10.Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS).
Haidet-Phillips AM, Maragakis NJ.
Brain Res. 2015 Dec 2;1628(Pt B):343-50. doi: 10.1016/j.brainres.2015.06.035. Review.
PMID: 26187754 [PubMed – indexed for MEDLINE]
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11.ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity.
Beers DR, Zhao W, Wang J, Zhang X, Wen S, Neal D, Thonhoff JR, Alsuliman AS, Shpall EJ, Rezvani K, Appel SH.
JCI Insight. 2017 Mar 9;2(5):e89530. doi: 10.1172/jci.insight.89530.
PMID: 28289705 [PubMed – in process] Free PMC Article
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12.Transplantation of mesenchymal stromal cells in patients with amyotrophic lateral sclerosis: Results of Phase I/IIa clinical trial.
Syková E, Rychmach P, Drahorádová I, Konrádová S, R?ži?ková K, Vo?íšek I, Forostyak S, Homola AE, Bojar M.
Cell Transplant. 2016 Nov 7. doi: 10.3727/096368916X693716. [Epub ahead of print]
PMID: 27938483 [PubMed – as supplied by publisher]
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13.Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS.
Park JH, Park HS, Hong S, Kang S.
Exp Mol Med. 2016 Dec 9;48(12):e276. doi: 10.1038/emm.2016.113.
PMID: 27932790 [PubMed – in process] Free PMC Article
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14.Neuronal cell sheet of cortical motor neuron phenotype derived from human iPS cells.
Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Takada E, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T.
Cell Transplant. 2017 Mar 17. doi: 10.3727/096368917X695245. [Epub ahead of print]
PMID: 28315294 [PubMed – as supplied by publisher]
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15.Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering.
Bernstock JD, Peruzzotti-Jametti L, Ye D, Gessler FA, Maric D, Vicario N, Lee YJ, Pluchino S, Hallenbeck JM.
J Cereb Blood Flow Metab. 2017 Jan 1:271678X17700432. doi: 10.1177/0271678X17700432. [Epub ahead of print]
PMID: 28303738 [PubMed – as supplied by publisher]
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16.White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke.
Otero-Ortega L, Laso-García F, Gómez-de Frutos MD, Rodríguez-Frutos B, Pascual-Guerra J, Fuentes B, Díez-Tejedor E, Gutiérrez-Fernández M.
Sci Rep. 2017 Mar 16;7:44433. doi: 10.1038/srep44433.
PMID: 28300134 [PubMed – in process] Free Article
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17.Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke.
Zhao K, Li R, Gu C, Liu L, Jia Y, Guo X, Zhang W, Pei C, Tian L, Li B, Jia J, Cheng H, Xu H, Li L.
Stem Cells Int. 2017;2017:2153629. doi: 10.1155/2017/2153629.
PMID: 28265288 [PubMed – in process] Free PMC Article
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