Small Fiber Peripheral Neuropathy: Gabapentin, Lyrica, and Cymbalta Don’t Address The Cause

Today we are discussing small fiber peripheral neuropathy, a condition that can independently be associated with severe foot and leg pain, but also is now being associated with fibromyalgia.  In today’s broadcast we will discuss new developments in the literature and seen in clinical practice that are being used to help those with this disabling neurological disorder.
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1.The Role and Importance of Small Fiber Neuropathy in Fibromyalgia Pain.
Caro XJ, Winter EF.
Curr Pain Headache Rep. 2015 Dec;19(12):55. doi: 10.1007/s11916-015-0527-7.
PMID: 26497568 [PubMed – in process]
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2.Peripheral Nerve Ultrasound in Small Fiber Polyneuropathy.
Ebadi H, Siddiqui H, Ebadi S, Ngo M, Breiner A, Bril V.
Ultrasound Med Biol. 2015 Nov;41(11):2820-6. doi: 10.1016/j.ultrasmedbio.2015.06.011. Epub 2015 Aug 28.
PMID: 26318562 [PubMed – in process]
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3.Effects of aldose reductase inhibitor on microneurographically assessed peripheral sympathetic nerve activity in rats.
Sato D, Kusunoki M, Shinzawa G, Feng Z, Nishina A, Nakamura T.
Auton Neurosci. 2015 Aug 8. pii: S1566-0702(15)30019-9. doi: 10.1016/j.autneu.2015.08.005. [Epub ahead of print]
PMID: 26272532 [PubMed – as supplied by publisher]
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4.Effects of exenatide on measures of diabetic neuropathy in subjects with type 2 diabetes: results from an 18-month proof-of-concept open-label randomized study.
Jaiswal M, Martin CL, Brown MB, Callaghan B, Albers JW, Feldman EL, Pop-Busui R.
J Diabetes Complications. 2015 Jul 17. pii: S1056-8727(15)00285-8. doi: 10.1016/j.jdiacomp.2015.07.013. [Epub ahead of print]
PMID: 26264399 [PubMed – as supplied by publisher]
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5.Neuropathic pain assessment: update on laboratory diagnostic tools.
Mainka T, Maier C, Enax-Krumova EK.
Curr Opin Anaesthesiol. 2015 Oct;28(5):537-45. doi: 10.1097/ACO.0000000000000223.
PMID: 26263122 [PubMed – in process]
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6.The New Age of Sudomotor Function Testing: A Sensitive and Specific Biomarker for Diagnosis, Estimation of Severity, Monitoring Progression, and Regression in Response to Intervention.
Vinik AI, Nevoret ML, Casellini C.
Front Endocrinol (Lausanne). 2015 Jun 11;6:94. doi: 10.3389/fendo.2015.00094. eCollection 2015. Review.
PMID: 26124748 [PubMed] Free PMC Article
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7.Improving assessment in small fiber neuropathy.
Brouwer BA, Bakkers M, Hoeijmakers JG, Faber CG, Merkies IS.
J Peripher Nerv Syst. 2015 Sep;20(3):333-40. doi: 10.1111/jns.12128.
PMID: 26114213 [PubMed – in process]
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8.Does prediabetes cause small fiber sensory polyneuropathy? Does it matter?
Kassardjian CD, Dyck PJ, Davies JL, Carter RE, Dyck PJ.
J Neurol Sci. 2015 Aug 15;355(1-2):196-8. doi: 10.1016/j.jns.2015.05.026. Epub 2015 May 27.
PMID: 26049659 [PubMed – in process]
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9.[American Academy of Neurology, Washington, 18-25 April 2015].
Sibon I, de Toffol B, Azulay JP, Sellal F, Thomas-Antérion C, Léger JM, Pierrot-Deseilligny C.
Rev Neurol (Paris). 2015 Jun-Jul;171(6-7):581-601. doi: 10.1016/j.neurol.2015.04.005. Epub 2015 May 23. Review. French.
PMID: 26005122 [PubMed – in process]
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10.Imaging signatures of altered brain responses in small-fiber neuropathy: reduced functional connectivity of the limbic system after peripheral nerve degeneration.
Hsieh PC, Tseng MT, Chao CC, Lin YH, Tseng WY, Liu KH, Chiang MC, Hsieh ST.
Pain. 2015 May;156(5):904-16. doi: 10.1097/j.pain.0000000000000128.
PMID: 25734991 [PubMed – in process]
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11.[Diagnosis of small-fiber neuropathy using various autonomic function tests].
Obayashi K, Ando Y.
Rinsho Shinkeigaku. 2014;54(12):1044-6. doi: 10.5692/clinicalneurol.54.1044. Japanese.
PMID: 25672704 [PubMed – indexed for MEDLINE]
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12.Progress in the treatment of small fiber peripheral neuropathy.
Chiang MC, Tseng MT, Pan CL, Chao CC, Hsieh ST.
Expert Rev Neurother. 2015 Mar;15(3):305-13. doi: 10.1586/14737175.2015.1013097. Epub 2015 Feb 9.
PMID: 25664678 [PubMed – in process]
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13.[Clinical, electrophysiological and skin biopsy studies of peripheral neuropathy with small fibers involvement: a report of 34 cases].
Sun B, Li Y, Liu L, Chen Z, Ling L, Yang F, Liu J, Liu H, Zhu W, Huang X.
Zhonghua Yi Xue Za Zhi. 2014 Nov 25;94(43):3397-401. Chinese.
PMID: 25622669 [PubMed – indexed for MEDLINE]
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14.[Diabetic neuropathy: do not only consider distal symmetrical neuropathy].
Doppler K, Reiners K.
Nervenarzt. 2015 Feb;86(2):161-6. doi: 10.1007/s00115-014-4127-2. German.
PMID: 25604836 [PubMed – in process]
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15.Prevalence of neuropathy in patients with impaired glucose tolerance using various electrophysiological tests.
Kannan MA, Sarva S, Kandadai RM, Paturi VR, Jabeen SA, Borgohain R.
Neurol India. 2014 Nov-Dec;62(6):656-61. doi: 10.4103/0028-3886.149393.
PMID: 25591680 [PubMed – indexed for MEDLINE] Free Article
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16.SCN9A Variants May be Implicated in Neuropathic Pain Associated With Diabetic Peripheral Neuropathy and Pain Severity.
Li QS, Cheng P, Favis R, Wickenden A, Romano G, Wang H.
Clin J Pain. 2015 Nov;31(11):976-82. doi: 10.1097/AJP.0000000000000205.
PMID: 25585270 [PubMed – in process]
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17.Small nerve fiber involvement in CMT1A.
Nolano M, Manganelli F, Provitera V, Pisciotta C, Stancanelli A, Caporaso G, Iodice R, Shy ME, Santoro L.
Neurology. 2015 Jan 27;84(4):407-14. doi: 10.1212/WNL.0000000000001188. Epub 2014 Dec 24.
PMID: 25540311 [PubMed – indexed for MEDLINE]
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18.Peripheral nervous system involvement in Parkinson’s disease: evidence and controversies.
Comi C, Magistrelli L, Oggioni GD, Carecchio M, Fleetwood T, Cantello R, Mancini F, Antonini A.
Parkinsonism Relat Disord. 2014 Dec;20(12):1329-34. doi: 10.1016/j.parkreldis.2014.10.010. Epub 2014 Oct 18. Review.
PMID: 25457816 [PubMed – indexed for MEDLINE] Free Article
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19.Microneurographic recording from unmyelinated nerve fibers in neurological disorders: an update.
Donadio V, Liguori R.
Clin Neurophysiol. 2015 Mar;126(3):437-45. doi: 10.1016/j.clinph.2014.10.009. Epub 2014 Oct 17. Review.
PMID: 25457652 [PubMed – indexed for MEDLINE]
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20.Glucose intolerance, metabolic syndrome, and neuropathy.
Cortez M, Singleton JR, Smith AG.
Handb Clin Neurol. 2014;126:109-22. doi: 10.1016/B978-0-444-53480-4.00009-6.
PMID: 25410218 [PubMed – in process]
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