Post Concussion Syndrome and Inflammation

Today we will be discussing new research connecting chronic inflammation with postconcussion syndrome and what this may mean to the post concussion syndrome patient population.

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1.A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS.
Rathbone AT, Tharmaradinam S, Jiang S, Rathbone MP, Kumbhare DA.
Brain Behav Immun. 2015 May;46:1-16. doi: 10.1016/j.bbi.2015.02.009. Epub 2015 Feb 28. Review.
PMID: 25736063 [PubMed – indexed for MEDLINE]
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2.The effect of an acute systemic inflammatory insult on the chronic effects of a single mild traumatic brain injury.
Collins-Praino LE, Arulsamy A, Katharesan V, Corrigan F.
Behav Brain Res2018 Jan 15;336:22-31. doi: 10.1016/j.bbr.2017.08.035. Epub 2017 Aug 30.
PMID: 28855139 [PubMed – in process]
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3.Current status of fluid biomarkers in mild traumatic brain injury.
Kulbe JR, Geddes JW.
Exp Neurol. 2016 Jan;275 Pt 3:334-352. doi: 10.1016/j.expneurol.2015.05.004. Epub 2015 May 14. Review.
PMID: 25981889 [PubMed – indexed for MEDLINE] Free PMC Article
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4.Elevated C-reactive protein levels may be a predictor of persistent unfavourable symptoms in patients with mild traumatic brain injury: a preliminary study.
Su SH, Xu W, Li M, Zhang L, Wu YF, Yu F, Hai J.
Brain Behav Immun. 2014 May;38:111-7. doi: 10.1016/j.bbi.2014.01.009. Epub 2014 Jan 21.
PMID: 24456846 [PubMed – indexed for MEDLINE]
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5.Improvements in balance control in individuals with PCS detected following vestibular training: A case study.
Prangley A, Aggerholm M, Cinelli M.
Gait Posture. 2017 Oct;58:229-231. doi: 10.1016/j.gaitpost.2017.08.006. Epub 2017 Aug 8.
PMID: 28822327 [PubMed – in process]
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6.Review of Vestibular and Oculomotor Screening and Concussion Rehabilitation.
Kontos AP, Deitrick JM, Collins MW, Mucha A.
J Athl Train. 2017 Mar;52(3):256-261. doi: 10.4085/1062-6050-51.11.05. Review.
PMID: 28387548 [PubMed – indexed for MEDLINE]
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7.Clinical predictors of vestibulo-ocular dysfunction in pediatric sports-related concussion.
Ellis MJ, Cordingley DM, Vis S, Reimer KM, Leiter J, Russell K.
J Neurosurg Pediatr. 2017 Jan;19(1):38-45. doi: 10.3171/2016.7.PEDS16310. Epub 2016 Sep 30.
PMID: 27689244 [PubMed – indexed for MEDLINE]
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8.Head-Eye Vestibular Motion Therapy Affects the Mental and Physical Health of Severe Chronic Postconcussion Patients.
Carrick FR, Clark JF, Pagnacco G, Antonucci MM, Hankir A, Zaman R, Oggero E.
Front Neurol. 2017 Aug 22;8:414. doi: 10.3389/fneur.2017.00414. eCollection 2017.
PMID: 28878731 [PubMed] Free PMC Article
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