Polycystic Ovarian Syndrome: Don’t Place All The Blame On Your Genetics.

Last week one of the United States premier morning shows discussed polycystic ovarian syndrome (PCOS), and relayed how this condition is not well understood and that genetics are to blame.  In today’s broadcast we will be discussing how we do not agree with these assertions.  Furthermore, we will delve into how those with chronic conditions are often told that they are suffering largely due to their genetics when in fact conditions such as PCOS can be improved through medical and natural treatments.
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1.Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin.
Sun X, Wu X, Zhou Y, Yu X, Zhang W.
Med Sci Monit. 2015 Aug 28;21:2547-52. doi: 10.12659/MSM.894926.
PMID: 26314870 [PubMed – in process]
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2.Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.
Jones MR, Brower MA, Xu N, Cui J, Mengesha E, Chen YD, Taylor KD, Azziz R, Goodarzi MO.
PLoS Genet. 2015 Aug 25;11(8):e1005455. doi: 10.1371/journal.pgen.1005455. eCollection 2015 Aug.
PMID: 26305227 [PubMed – in process] Free Article
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3.WITHDRAWN: Gonadotrophin therapy for ovulation induction in subfertility associated with polycystic ovary syndrome.
Nugent D, Vanderkerchove P, Hughes E, Arnot M, Lilford R.
Cochrane Database Syst Rev. 2015 Aug 24;8:CD000410. [Epub ahead of print] Review.
PMID: 26299777 [PubMed – as supplied by publisher]
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4.Increased insulin-like growth factor-1 in relation to cardiovascular function in polycystic ovary syndrome: friend or foe?
Desai NA, Patel SS.
Gynecol Endocrinol. 2015 Aug 19:1-7. [Epub ahead of print]
PMID: 26288196 [PubMed – as supplied by publisher]
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5.Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome.
Iwata MC, Porquere L, Sorpreso IC, Baracat EC, Soares Júnior JM.
Rev Assoc Med Bras. 2015 May-Jun;61(3):215-9. doi: 10.1590/1806-9282.61.03.215.
PMID: 26248242 [PubMed – in process] Free Article
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6.Transcutaneous electrical acupoint stimulation alleviates the hyperandrogenism of polycystic ovarian syndrome rats by regulating the expression of P450arom and CTGF in the ovaries.
Qu F, Liang Y, Zhou J, Ma RJ, Zhou J, Wang FF, Wu Y, Fang JQ.
Int J Clin Exp Med. 2015 May 15;8(5):7754-61. eCollection 2015.
PMID: 26221326 [PubMed] Free PMC Article
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7.A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.
Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL.
Biol Reprod. 2015 Jul 22. pii: biolreprod.115.131631. [Epub ahead of print]
PMID: 26203175 [PubMed – as supplied by publisher] Free Article
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8.Effect of Ramadan Fasting on Stress Neurohormones in Women with Polycystic Ovary Syndrome.
Zangeneh F, Salman Yazdi R, Naghizadeh MM, Abedinia N.
J Family Reprod Health. 2015 Jun;9(2):51-7.
PMID: 26175759 [PubMed] Free PMC Article
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9.Anti-mullerian hormon level and polycystic ovarian syndrome diagnosis.
Zadehmodarres S, Heidar Z, Razzaghi Z, Ebrahimi L, Soltanzadeh K, Abed F.
Iran J Reprod Med. 2015 Apr;13(4):227-30.
PMID: 26131012 [PubMed] Free PMC Article
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10.Effects of brain-derived neurotrophic factor on oocyte maturation and embryonic development in a rat model of polycystic ovary syndrome.
Zhang Q, Liu D, Zhang M, Li N, Lu S, Du Y, Chen ZJ.
Reprod Fertil Dev. 2015 Jun 25. doi: 10.1071/RD15131. [Epub ahead of print]
PMID: 26108912 [PubMed – as supplied by publisher]
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11.Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism.
Suresh S, Vijayakumar T.
Indian J Clin Biochem. 2015 Jul;30(3):345-50. doi: 10.1007/s12291-014-0447-z. Epub 2014 Jun 1.
PMID: 26089623 [PubMed]
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12.Association of insulin resistance with lipid profile, metabolic syndrome, and hormonal aberrations in overweight or obese women with polycystic ovary syndrome.
Ebrahimi-Mamaghani M, Saghafi-Asl M, Pirouzpanah S, Aliasgharzadeh A, Aliashrafi S, Rezayi N, Mehrzad-Sadaghiani M.
J Health Popul Nutr. 2015 Mar;33(1):157-67.
PMID: 25995732 [PubMed – indexed for MEDLINE] Free PMC Article
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13.Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.
Saxena R, Bjonnes AC, Georgopoulos NA, Koika V, Panidis D, Welt CK.
Hum Reprod. 2015 Jul;30(7):1697-703. doi: 10.1093/humrep/dev110. Epub 2015 May 20.
PMID: 25994816 [PubMed – in process]
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14.Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH; Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A.
Nat Commun. 2015 Aug 18;6:7502. doi: 10.1038/ncomms8502.
PMID: 26284813 [PubMed – in process]
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15.Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.
Zhao S, Tian Y, Gao X, Zhang X, Liu H, You L, Cao Y, Su S, Chan WY, Sun Y, Zhao H, Chen ZJ.
Sci Rep. 2015 Jul 29;5:12619. doi: 10.1038/srep12619.
PMID: 26220222 [PubMed – in process] Free PMC Article
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16.Causes of endometriosis and prevalent infertility in patients undergoing laparoscopy without achieving pregnancy.
de Oliveira R, Adami F, Mafra FA, Bianco B, Vilarino FL, Barbosa CP.
Minerva Ginecol. 2015 Jun 30. [Epub ahead of print]
PMID: 26126067 [PubMed – as supplied by publisher]
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17.Genetics of insulin resistance in polycystic ovary syndrome.
Obermayer-Pietsch B, Trummer C, Schwetz V, Schweighofer N, Pieber T.
Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):401-6. doi: 10.1097/MCO.0000000000000190.
PMID: 26049638 [PubMed – in process]
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18.[Association of methylenetetrahydrofolate reductase gene polymorphisms with polycystic ovary syndrome].
Qi Q, Zhang H, Yu M, Wang X, Wang Z, Xu L, Wang J, Mu H.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Jun;32(3):400-4. doi: 10.3760/cma.j.issn.1003-9406.2015.03.022. Chinese.
PMID: 26037361 [PubMed – indexed for MEDLINE]
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19.Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women.
Ha L, Shi Y, Zhao J, Li T, Chen ZJ.
PLoS One. 2015 May 15;10(5):e0126505. doi: 10.1371/journal.pone.0126505. eCollection 2015.
PMID: 25978310 [PubMed – in process] Free PMC Article
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20.Molecular genetics of polycystic ovary syndrome: an update.
Li L, Baek KH.
Curr Mol Med. 2015;15(4):331-42.
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21.Acne – a potential skin marker of internal disease.
Pace JL.
Clin Dermatol. 2015 Sep-Oct;33(5):572-8. doi: 10.1016/j.clindermatol.2015.05.010. Epub 2015 May 27.
PMID: 26321405 [PubMed – in process]
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22.Effects of metformin on mitochondrial function of leukocytes from polycystic ovary syndrome patients with insulin resistance.
Victor VM, Rovira-Llopis S, Bañuls C, Diaz-Morales N, Castello R, Falcon R, Gomez M, Rocha M, Hernandez Mijares A.
Eur J Endocrinol. 2015 Aug 28. pii: EJE-15-0572. [Epub ahead of print]
PMID: 26320144 [PubMed – as supplied by publisher]
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23.Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z.
Biol Trace Elem Res. 2015 Aug 28. [Epub ahead of print]
PMID: 26315303 [PubMed – as supplied by publisher]
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24.Ovarian actions of resveratrol.
Ortega I, Duleba AJ.
Ann N Y Acad Sci. 2015 Aug;1348(1):86-96. doi: 10.1111/nyas.12875.
PMID: 26315293 [PubMed – in process]
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25.WITHDRAWN: Recombinant FSH versus urinary gonadotrophins or recombinant FSH for ovulation induction in subfertility associated with polycystic ovary syndrome.
Nahuis M, Bayram N, Van der Veen F, van Wely M.
Cochrane Database Syst Rev. 2015 Aug 24;8:CD002121. [Epub ahead of print] Review.
PMID: 26299778 [PubMed – as supplied by publisher]
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26.Hyperinsulinism and polycystic ovary syndrome (PCOS): role of insulin clearance.
Amato MC, Vesco R, Vigneri E, Ciresi A, Giordano C.
J Endocrinol Invest. 2015 Aug 21. [Epub ahead of print]
PMID: 26294351 [PubMed – as supplied by publisher]
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27.Are serum chemerin levels different between obese and non-obese polycystic ovary syndrome women?
Yang S, Wang Q, Huang W, Song Y, Feng G, Zhou L, Tan J.
Gynecol Endocrinol. 2015 Aug 19:1-4. [Epub ahead of print]
PMID: 26291816 [PubMed – as supplied by publisher]
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28.The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome.
Maged AM, Elsawah H, Abdelhafez A, Bakry A, Mostafa WA.
Gynecol Endocrinol. 2015 Aug 6:1-4. [Epub ahead of print]
PMID: 26291797 [PubMed – as supplied by publisher]
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29.Relationship between pelvic floor muscle and hormone levels in polycystic ovary syndrome.
Micussi MT, Freitas RP, Varella L, Soares EM, Lemos TM, Maranhão TM.
Neurourol Urodyn. 2015 Aug 19. doi: 10.1002/nau.22817. [Epub ahead of print]
PMID: 26288062 [PubMed – as supplied by publisher]
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30.Epigenetic regulation of traf2- and Nck-interacting kinase (TNIK) in polycystic ovary syndrome.
Li D, Jiao J, Zhou YM, Wang XX.
Am J Transl Res. 2015 Jun 15;7(6):1152-60. eCollection 2015.
PMID: 26279758 [PubMed] Free PMC Article
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31.Complications and challenges associated with polycystic ovary syndrome: current perspectives.
Palomba S, Santagni S, Falbo A, La Sala GB.
Int J Womens Health. 2015 Jul 31;7:745-63. doi: 10.2147/IJWH.S70314. eCollection 2015. Review.
PMID: 26261426 [PubMed] Free PMC Article
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32.Anti-Inflammatory Dietary Combo in Overweight and Obese Women with Polycystic Ovary Syndrome.
Salama AA, Amine EK, Salem HA, Abd El Fattah NK.
N Am J Med Sci. 2015 Jul;7(7):310-6. doi: 10.4103/1947-2714.161246.
PMID: 26258078 [PubMed] Free PMC Article
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