Multiple Sclerosis: Should You Have Your Blood Brain Barrier Checked?

Today we are discussing the blood brain barrier as it relates to Multiple Sclerosis.  Multiple Sclerosis is an autoimmune disease where the immune system attacks brain and spinal cord tissue.  In previous broadcasts we have discussed how the gut interacts with M.S. patients, and today we will take it a step further in expanding upon how breakdown of the blood  brain barrier is involved in the M.S. disease process.
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2.Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins.
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3.Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain.
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5.Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin.
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6.Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery.
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7.Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.
Nouri M, Bredberg A, Weström B, Lavasani S.
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8.Immune-Reconstitution Inflammatory Syndrome in Multiple Sclerosis Patients Treated With Natalizumab: A Series of 4 Cases.
N’gbo N’gbo Ikazabo R, Mostosi C, Quivron B, Delberghe X, El Hafsi K, Lysandropoulos AP.
Clin Ther. 2016 Feb 4. pii: S0149-2918(16)00023-0. doi: 10.1016/j.clinthera.2016.01.010. [Epub ahead of print]
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9.Important role of mast cells in multiple sclerosis.
Conti P, Kempuraj D.
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10.The Choroid Plexus in Healthy and Diseased Brain.
Kaur C, Rathnasamy G, Ling EA.
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11.Analysis of miRNA in Normal Appearing White Matter to Identify Altered CNS Pathways in Multiple Sclerosis.
Guerau-de-Arellano M, Liu Y, Meisen WH, Pitt D, Racke MK, Lovett-Racke AE.
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12.The use of immune modulating drugs for the treatment of multiple sclerosis.
Al-Khamis FA.
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13.Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System.
Waschbisch A, Schröder S, Schraudner D, Sammet L, Weksler B, Melms A, Pfeifenbring S, Stadelmann C, Schwab S, Linker RA.
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14.JAML mediates monocyte and CD8 T cell migration across the brain endothelium.
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15.Microglia-blood vessel interactions: a double-edged sword in brain pathologies.
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17.Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores Blood-Brain-Barrier Integrity and Ameliorates Disease Severity.
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