Today we are discussing the blood brain barrier as it relates to Multiple Sclerosis. Multiple Sclerosis is an autoimmune disease where the immune system attacks brain and spinal cord tissue. In previous broadcasts we have discussed how the gut interacts with M.S. patients, and today we will take it a step further in expanding upon how breakdown of the blood brain barrier is involved in the M.S. disease process.
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References:
| 1. | Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. |
| Fasano A. | |
| Clin Gastroenterol Hepatol. 2012 Oct;10(10):1096-100. doi: 10.1016/j.cgh.2012.08.012. Epub 2012 Aug 16. Review. | |
| PMID: 22902773 [PubMed – indexed for MEDLINE] Free PMC Article | |
| Similar articles |
| 2. | Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. |
| Fasano A, Nataro JP. | |
| Adv Drug Deliv Rev. 2004 Apr 19;56(6):795-807. Review. | |
| PMID: 15063590 [PubMed – indexed for MEDLINE] | |
| Similar articles |
| 3. | Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. |
| Di Pierro M, Lu R, Uzzau S, Wang W, Margaretten K, Pazzani C, Maimone F, Fasano A. | |
| J Biol Chem. 2001 Jun 1;276(22):19160-5. Epub 2001 Feb 14. | |
| PMID: 11278543 [PubMed – indexed for MEDLINE] Free Article | |
| Similar articles |
| 4. | Human zonulin, a potential modulator of intestinal tight junctions. |
| Wang W, Uzzau S, Goldblum SE, Fasano A. | |
| J Cell Sci. 2000 Dec;113 Pt 24:4435-40. | |
| PMID: 11082037 [PubMed – indexed for MEDLINE] Free Article | |
| Similar articles |
| 5. | Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin. |
| Fasano A. | |
| Ann N Y Acad Sci. 2000;915:214-22. Review. | |
| PMID: 11193578 [PubMed – indexed for MEDLINE] | |
| Similar articles |
| 6. | Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. |
| Deli MA. | |
| Biochim Biophys Acta. 2009 Apr;1788(4):892-910. doi: 10.1016/j.bbamem.2008.09.016. Epub 2008 Oct 17. Review. | |
| PMID: 18983815 [PubMed – indexed for MEDLINE] Free Article | |
| Similar articles |
| 7. | Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells. |
| Nouri M, Bredberg A, Weström B, Lavasani S. | |
| PLoS One. 2014 Sep 3;9(9):e106335. doi: 10.1371/journal.pone.0106335. eCollection 2014. | |
| PMID: 25184418 [PubMed – indexed for MEDLINE] Free PMC Article | |
| Similar articles |
| 8. | Immune-Reconstitution Inflammatory Syndrome in Multiple Sclerosis Patients Treated With Natalizumab: A Series of 4 Cases. |
| N’gbo N’gbo Ikazabo R, Mostosi C, Quivron B, Delberghe X, El Hafsi K, Lysandropoulos AP. | |
| Clin Ther. 2016 Feb 4. pii: S0149-2918(16)00023-0. doi: 10.1016/j.clinthera.2016.01. | |
| PMID: 26856928 [PubMed – as supplied by publisher] | |
| Similar articles |
| 9. | Important role of mast cells in multiple sclerosis. |
| Conti P, Kempuraj D. | |
| Mult Scler Relat Disord. 2016 Jan;5:77-80. doi: 10.1016/j.msard.2015.11.005. Epub 2015 Nov 11. Review. | |
| PMID: 26856948 [PubMed – in process] | |
| Similar articles |
| 10. | The Choroid Plexus in Healthy and Diseased Brain. |
| Kaur C, Rathnasamy G, Ling EA. | |
| J Neuropathol Exp Neurol. 2016 Feb 17. pii: nlv030. [Epub ahead of print] Review. | |
| PMID: 26888305 [PubMed – as supplied by publisher] | |
| Similar articles |
| 11. | Analysis of miRNA in Normal Appearing White Matter to Identify Altered CNS Pathways in Multiple Sclerosis. |
| Guerau-de-Arellano M, Liu Y, Meisen WH, Pitt D, Racke MK, Lovett-Racke AE. | |
| J Autoimmune Disord. 2015;1(1). pii: 6. | |
| PMID: 26894232 [PubMed] Free PMC Article | |
| Similar articles |
| 12. | The use of immune modulating drugs for the treatment of multiple sclerosis. |
| Al-Khamis FA. | |
| Neurosciences (Riyadh). 2016 Jan;21(1):4-9. doi: 10.17712/nsj.2016.1.20150252. | |
| PMID: 26818160 [PubMed – in process] | |
| Similar articles |
| 13. | Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System. |
| Waschbisch A, Schröder S, Schraudner D, Sammet L, Weksler B, Melms A, Pfeifenbring S, Stadelmann C, Schwab S, Linker RA. | |
| J Immunol. 2016 Feb 15;196(4):1558-67. doi: 10.4049/jimmunol.1501960. Epub 2016 Jan 8. | |
| PMID: 26746191 [PubMed – in process] | |
| Similar articles |
| 14. | JAML mediates monocyte and CD8 T cell migration across the brain endothelium. |
| Alvarez JI, Kébir H, Cheslow L, Chabarati M, Larochelle C, Prat A. | |
| Ann Clin Transl Neurol. 2015 Sep 29;2(11):1032-7. doi: 10.1002/acn3.255. eCollection 2015 Nov. | |
| PMID: 26734656 [PubMed] Free PMC Article | |
| Similar articles |
| 15. | Microglia-blood vessel interactions: a double-edged sword in brain pathologies. |
| Dudvarski Stankovic N, Teodorczyk M, Ploen R, Zipp F, Schmidt MH. | |
| Acta Neuropathol. 2016 Mar;131(3):347-63. doi: 10.1007/s00401-015-1524-y. Epub 2015 Dec 28. | |
| PMID: 26711460 [PubMed – in process] | |
| Similar articles |
| 16. | The Ins and Outs of B Cells in Multiple Sclerosis. |
| Blauth K, Owens GP, Bennett JL. | |
| Front Immunol. 2015 Nov 5;6:565. doi: 10.3389/fimmu.2015.00565. eCollection 2015. Review. | |
| PMID: 26594215 [PubMed] Free PMC Article | |
| Similar articles |
| 17. | Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores Blood-Brain-Barrier Integrity and Ameliorates Disease Severity. |
| Zhang H, Ray A, Miller NM, Hartwig D, Pritchard KA Jr, Dittel BN. | |
| J Neurochem. 2015 Nov 12. doi: 10.1111/jnc.13426. [Epub ahead of print] | |
| PMID: 26560636 [PubMed – as supplied by publisher] | |
| Similar articles |
