Migraines: What To Do When Medications and Botox Stop Working?

Today we are discussing migraines, and we will delve into the details associated with this condition.  However, the main focus of today’s broadcast is to provide information for those with medication refractory migraines, as the new literature is demonstrating some exciting areas for novel treatments of this often debilitating condition.
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References:
1. Reduction of CD4(+)CD25(+) regulatory T-cells in migraine: Is migraine an autoimmune disorder?
Arumugam M, Parthasarathy V.
J Neuroimmunol. 2016 Jan 15;290:54-9. doi: 10.1016/j.jneuroim.2015.11.015.
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2. Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism.
Török N, Majláth Z, Fülöp F, Toldi J, Vécsei L.
Curr Drug Metab. 2016;17(5):412-29.
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3. Genetic insights into migraine and glutamate: a protagonist driving the headache.
Gasparini CF, Smith RA, Griffiths LR.
J Neurol Sci. 2016 Aug 15;367:258-68. doi: 10.1016/j.jns.2016.06.016. Review.
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4. Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.
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5. Case-control study of GRIA1 and GRIA3 gene variants in migraine.
Fang J, An X, Chen S, Yu Z, Ma Q, Qu H.
J Headache Pain. 2015;17:2. doi: 10.1186/s10194-016-0592-2.
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6. Promoting sympathovagal balance in multiple sclerosis; pharmacological, non-pharmacological, and surgical strategies.
Sternberg Z.
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7. High headache-related disability in patients with systemic lupus erythematosus and primary Sjögren’s syndrome.
Tjensvoll AB, Gøransson LG, Harboe E, Kvaløy JT, Omdal R.
Eur J Neurol. 2014 Aug;21(8):1124-30. doi: 10.1111/ene.12447.
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8. Histamine pharmacology: four years on.
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9. Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial.
Friedman BW, Cabral L, Adewunmi V, Solorzano C, Esses D, Bijur PE, Gallagher EJ.
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10. Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study.
Teggi R, Colombo B, Gatti O, Comi G, Bussi M.
Neurol Sci. 2015 Oct;36(10):1869-73. doi: 10.1007/s10072-015-2270-6.
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11. Acupuncture for migraine prevention.
Da Silva AN.
Headache. 2015 Mar;55(3):470-3. doi: 10.1111/head.12525. Review.
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12. A comparison of acute treatment regimens for migraine in the emergency department.
Bachur RG, Monuteaux MC, Neuman MI.
Pediatrics. 2015 Feb;135(2):232-8. doi: 10.1542/peds.2014-2432.
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13. Cinnarizine: a promising agent for migraine prevention you may never get the chance to use.
DiSabella MT.
Pediatr Neurol. 2014 Oct;51(4):475. doi: 10.1016/j.pediatrneurol.2014.07.002. No abstract available.
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14. Efficacy and safety of cinnarizine in the prophylaxis of migraine in children: a double-blind placebo-controlled randomized trial.
Ashrafi MR, Salehi S, Malamiri RA, Heidari M, Hosseini SA, Samiei M, Tavasoli AR, Togha M.
Pediatr Neurol. 2014 Oct;51(4):503-8. doi: 10.1016/j.pediatrneurol.2014.05.031.
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15. Clinicopharmacological comparative study of rizatriptan versus conventional therapy in migraine.
Kushwah A, Tomar A.
J Indian Med Assoc. 2014 Jan;112(1):17-8, 20.
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Alstadhaug KB.
Headache. 2014 Feb;54(2):246-59. doi: 10.1111/head.12293. Review.
PMID: 24433203 [PubMed – indexed for MEDLINE]
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17. Sex-related influences in migraine.
Pavlovic JM, Akcali D, Bolay H, Bernstein C, Maleki N.
J Neurosci Res. 2017 Jan 2;95(1-2):587-593. doi: 10.1002/jnr.23903. Review.
PMID: 27870430 [Unknown status]
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18. The influence of estrogen on migraine: a systematic review.
Brandes JL.
JAMA. 2006 Apr 19;295(15):1824-30. Review.
PMID: 16622144 [PubMed – indexed for MEDLINE]
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19. Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis.
Borkum JM.
Headache. 2016 Jan;56(1):12-35. doi: 10.1111/head.12725. Review.
PMID: 26639834 [PubMed – in process] Free Article
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20. Headache Disorders May Be a Risk Factor for the Development of New Onset Hypothyroidism.
Martin AT, Pinney SM, Xie C, Herrick RL, Bai Y, Buckholz J, Martin VT.
Headache. 2016 Sep 27. doi: 10.1111/head.12943. [Epub ahead of print]
PMID: 27676320 [PubMed – as supplied by publisher]
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21. MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome.
Glintborg D, Andersen M.
Eur J Endocrinol. 2016 Sep 6. pii: EJE-16-0373. [Epub ahead of print]
PMID: 27601016 [PubMed – as supplied by publisher]
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22. Migraine: is it related to hormonal disturbances or stress?
Parashar R, Bhalla P, Rai NK, Pakhare A, Babbar R.
Int J Womens Health. 2014 Oct 24;6:921-5. doi: 10.2147/IJWH.S62922.
PMID: 25368535 [PubMed] Free PMC Article
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23. Frequency of subclinical hypothyroidism in 5- to 15-year-old children with migraine headache.
Fallah R, Mirouliaei M, Bashardoost N, Partovee M.
J Pediatr Endocrinol Metab. 2012;25(9-10):859-62. doi: 10.1515/jpem-2012-0121.
PMID: 23426813 [PubMed – indexed for MEDLINE]
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24. Functional mitochondrial analysis in acute brain sections from adult rats reveals mitochondrial dysfunction in a rat model of migraine.
Fried NT, Moffat C, Seifert EL, Oshinsky ML.
Am J Physiol Cell Physiol. 2014 Dec 1;307(11):C1017-30. doi: 10.1152/ajpcell.00332.2013.
PMID: 25252946 [PubMed – indexed for MEDLINE] Free PMC Article
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25. Riboflavin and migraine: the bridge over troubled mitochondria.
Colombo B, Saraceno L, Comi G.
Neurol Sci. 2014 May;35 Suppl 1:141-4. doi: 10.1007/s10072-014-1755-z.
PMID: 24867851 [PubMed – indexed for MEDLINE]
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