Lysine and its Antiviral Properties, as it Relates to its Potential in Helping Herpes Simplex, Chronic Fatigue, and Vestibular Neuritis

Today we are discussing a powerful compound termed Lysine.  Though Lysine is an amino acid in our food, studies have shown this natural compound to be effective in helping viral infections.  Today we will discuss the literature as well as the clinical utility of this, and the results of Lysine we have recently observed in our practice.
Please enjoy, and send us your questions.  Please forward us any questions here on our website or go to our Power Health Facebook page
1.Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM.
Sci Transl Med. 2014 Dec 3;6(265):265ra169. doi: 10.1126/scitranslmed.3010643.
PMID: 25473037 [PubMed – in process]
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2.Analysis and prediction of highly effective antiviral peptides based on random forests.
Chang KY, Yang JR.
PLoS One. 2013 Aug 5;8(8):e70166. doi: 10.1371/journal.pone.0070166. Print 2013.
PMID: 23940542 [PubMed – indexed for MEDLINE] Free PMC Article
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3.Novel antiviral therapeutics to control foot-and-mouth disease.
Dias CC, Moraes MP, Weiss M, Diaz-San Segundo F, Perez-Martin E, Salazar AM, de los Santos T, Grubman MJ.
J Interferon Cytokine Res. 2012 Oct;32(10):462-73. doi: 10.1089/jir.2012.0012. Epub 2012 Aug 27.
PMID: 22924938 [PubMed – indexed for MEDLINE]
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4.Novel anti-HIV-1 activity produced by conjugating unsulfated dextran with polyL-lysine.
Nakamura K, Ohtsuki T, Mori H, Hoshino H, Hoque A, Oue A, Kano F, Sakagami H, Tanamoto K, Ushijima H, Kawasaki N, Akiyama H, Ogawa H.
Antiviral Res. 2012 Apr;94(1):89-97. doi: 10.1016/j.antiviral.2012.02.011. Epub 2012 Mar 3.
PMID: 22401805 [PubMed – indexed for MEDLINE]
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5.Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.
Zeng W, Xu M, Liu S, Sun L, Chen ZJ.
Mol Cell. 2009 Oct 23;36(2):315-25. doi: 10.1016/j.molcel.2009.09.037.
PMID: 19854139 [PubMed – indexed for MEDLINE] Free PMC Article
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6.Tranylcypromine reduces herpes simplex virus 1 infection in mice.
Yao HW, Lin PH, Shen FH, Perng GC, Tung YY, Hsu SM, Chen SH.
Antimicrob Agents Chemother. 2014 May;58(5):2807-15. doi: 10.1128/AAC.02617-13. Epub 2014 Mar 3.
PMID: 24590478 [PubMed – in process] Free PMC Article
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7.Prophylaxis against Herpes Simplex Virus reactivation in patients with facial burns: a potential role for L-lysine.
Roberts JJ, Solanki NS, Kurmis R, Lammerink S, Wong KL, Greenwood JE.
J Burn Care Res. 2013 Nov-Dec;34(6):e368-9. doi: 10.1097/BCR.0b013e3182685b59. No abstract available.
PMID: 23128138 [PubMed – indexed for MEDLINE]
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8.Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis.
Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A.
Dermatologica. 1987;175(4):183-90.
PMID: 3115841 [PubMed – indexed for MEDLINE]
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9.Could lysine supplementation prevent Alzheimer’s dementia? A novel hypothesis.
Rubey RN.
Neuropsychiatr Dis Treat. 2010 Oct 27;6:707-10. doi: 10.2147/NDT.S14338.
PMID: 21127688 [PubMed] Free PMC Article
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10.Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA export.
Corbin-Lickfett KA, Souki SK, Cocco MJ, Sandri-Goldin RM.
J Virol. 2010 Jul;84(13):6367-76. doi: 10.1128/JVI.00509-10. Epub 2010 Apr 21.
PMID: 20410270 [PubMed – indexed for MEDLINE] Free PMC Article
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11.Antiviral activity of esterified alpha-lactalbumin and beta-lactoglobulin against herpes simplex virus type 1. Comparison with the effect of acyclovir and L-polylysines.
Sitohy M, Billaudel S, Haertlé T, Chobert JM.
J Agric Food Chem. 2007 Dec 12;55(25):10214-20. Epub 2007 Nov 9.
PMID: 17990848 [PubMed – indexed for MEDLINE]
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12.L-lysine. Monograph.
[No authors listed]
Altern Med Rev. 2007 Jun;12(2):169-72. No abstract available.
PMID: 17604462 [PubMed – indexed for MEDLINE] Free Article
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13.By the way, doctor. For years, I was plagued by cold sores and took antiviral drugs to treat the outbreaks. But at a friend’s suggestion, I started taking lysine every day, and it seems to prevent them altogether. What do you know about this supplement?
Robb-Nicholson C.
Harv Womens Health Watch. 2007 Mar;14(7):8. No abstract available.
PMID: 17393593 [PubMed – indexed for MEDLINE]
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14.Subjective response to lysine in the therapy of herpes simplex.
Walsh DE, Griffith RS, Behforooz A.
J Antimicrob Chemother. 1983 Nov;12(5):489-96.
PMID: 6423612 [PubMed – indexed for MEDLINE]
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15.[Antiviral and non-antiviral general treatments for oro-facial and genital herpes (pregnancy and neonates excluded)].
Guillaume JC.
Ann Dermatol Venereol. 2002 Apr;129(4 Pt 2):625-34. Review. French.
PMID: 12122333 [PubMed – indexed for MEDLINE]
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16.Natural remedies for Herpes simplex.
Gaby AR.
Altern Med Rev. 2006 Jun;11(2):93-101. Review.
PMID: 16813459 [PubMed – indexed for MEDLINE] Free Article
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17.Genital herpes: a review.
Beauman JG.
Am Fam Physician. 2005 Oct 15;72(8):1527-34. Review.
PMID: 16273819 [PubMed – indexed for MEDLINE] Free Article
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18.Therapeutic options for herpes labialis: experimental and natural therapies.
Elish D, Singh F, Weinberg JM.
Cutis. 2005 Jul;76(1):38-40. Review.
PMID: 16144287 [PubMed – indexed for MEDLINE]
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19.Current management and recommendations for access to antiviral therapy of herpes labialis.
Cunningham A, Griffiths P, Leone P, Mindel A, Patel R, Stanberry L, Whitley R.
J Clin Virol. 2012 Jan;53(1):6-11. doi: 10.1016/j.jcv.2011.08.003. Epub 2011 Sep 1. Review.
PMID: 21889905 [PubMed – indexed for MEDLINE] Free PMC Article
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20.Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.
Singh BB, Udani J, Vinjamury SP, Der-Martirosian C, Gandhi S, Khorsan R, Nanjegowda D, Singh V.
Altern Med Rev. 2005 Jun;10(2):123-7.
PMID: 15989381 [PubMed – indexed for MEDLINE] Free Article
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21.Thirteen-week oral toxicity study of L-lysine hydrochloride in rats.
Tsubuku S, Mochizuki M, Mawatari K, Smriga M, Kimura T.
Int J Toxicol. 2004 Mar-Apr;23(2):113-8.
PMID: 15204731 [PubMed – indexed for MEDLINE]
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22.[Effect of L-lysine-alpha-oxidase gel on development of ophthalmic herpes and herpetic skin lesions in rabbit].
Smirnova IP, Alekseev SB, Podboronov VM.
Antibiot Khimioter. 2003;48(11):7-9. Russian.
PMID: 15106305 [PubMed – indexed for MEDLINE]
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23.[Antiherpetic activity of l-lysine-alpha-oxidase in different dosage forms].
Selishcheva AA, Alekseev SB, Smirnova IP, Podboronov VM.
Antibiot Khimioter. 2003;48(1):9-12. Russian.
PMID: 12741316 [PubMed – indexed for MEDLINE]
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24.Will taking the amino acid supplement lysine prevent or treat the herpes simplex virus?
Marcason W.
J Am Diet Assoc. 2003 Mar;103(3):351. No abstract available.
PMID: 12616258 [PubMed – indexed for MEDLINE]
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25.Lysine for management of herpes labialis.
Tomblin FA Jr, Lucas KH.
Am J Health Syst Pharm. 2001 Feb 15;58(4):298-300, 304. Review. No abstract available.
PMID: 11225166 [PubMed – indexed for MEDLINE]
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26.[Effect of L-lysine-a-oxidase on reproduction of herpes simplex type I virus in vitro].
Smirnova IP, Diorditsa SV, Alekseev SB, Za?tsev IZ.
Vopr Med Khim. 1998 Jul-Aug;44(4):384-7. Russian.
PMID: 9845927 [PubMed – indexed for MEDLINE]
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27.The metabolic roles, pharmacology, and toxicology of lysine.
Flodin NW.
J Am Coll Nutr. 1997 Feb;16(1):7-21. Review.
PMID: 9013429 [PubMed – indexed for MEDLINE]
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