Is your GERD medication causing a B12 deficiency?

Today we are discussing medications used for Gastroesophageal Reflux Disease (GERD) and their association with vitamin B12 deficiency.  Though in last weeks broadcast we commented that B12 deficiency is not the only cause of chronic fatigue, it can be associated with a host of neurological and metabolic diseases.
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1.Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency.
Lam JR, Schneider JL, Zhao W, Corley DA.
JAMA. 2013 Dec 11;310(22):2435-42. doi: 10.1001/jama.2013.280490.
PMID: 24327038 [PubMed – indexed for MEDLINE]
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2.Perils and pitfalls of long-term effects of proton pump inhibitors.
Wilhelm SM, Rjater RG, Kale-Pradhan PB.
Expert Rev Clin Pharmacol. 2013 Jul;6(4):443-51. doi: 10.1586/17512433.2013.811206. Review.
PMID: 23927671 [PubMed – indexed for MEDLINE]
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3.Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications.
Heidelbaugh JJ.
Ther Adv Drug Saf. 2013 Jun;4(3):125-33. doi: 10.1177/2042098613482484.
PMID: 25083257 [PubMed] Free PMC Article
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4.Impact of clinical pharmacists’ recommendations on a proton pump inhibitor taper protocol in an ambulatory care practice.
Bundeff AW, Zaiken K.
J Manag Care Pharm. 2013 May;19(4):325-33.
PMID: 23627578 [PubMed – indexed for MEDLINE] Free Article
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5.[Adverse events associated with long-term use of proton pump inhibitors].
Reimer C, Bytzer P.
Ugeskr Laeger. 2012 Sep 24;174(39):2289-93. Danish.
PMID: 23006222 [PubMed – indexed for MEDLINE]
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6.Long-term medical management of gastro-esophageal reflux disease: how long and when to consider surgery?
Venkataraman J, Krishnan A.
Trop Gastroenterol. 2012 Jan-Mar;33(1):21-32. Review.
PMID: 22803292 [PubMed – indexed for MEDLINE] Free Article
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7.Proton pump inhibitors–uncommon adverse effects.
Oh S.
Aust Fam Physician. 2011 Sep;40(9):705-8.
PMID: 21894279 [PubMed – indexed for MEDLINE] Free Article
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8.An old dietary regimen as a new lifestyle change for Gastro esophageal reflux disease: A pilot study.
Randhawa MA, Mahfouz SA, Selim NA, Yar T, Gillessen A.
Pak J Pharm Sci. 2015 Sep;28(5):1583-6.
PMID: 26408867 [PubMed – in process]
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9.Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States.
Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM, Jensen ET, Lund JL, Pasricha S, Runge T, Schmidt M, Shaheen NJ, Sandler RS.
Gastroenterology. 2015 Aug 28. pii: S0016-5085(15)01242-1. doi: 10.1053/j.gastro.2015.08.045. [Epub ahead of print]
PMID: 26327134 [PubMed – as supplied by publisher]
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10.[Pathophysiology and treatment of reflux esophagitis].
Iwakiri K, Kawami N.
Nihon Rinsho. 2015 Jul;73(7):1098-102. Japanese.
PMID: 26165064 [PubMed – indexed for MEDLINE]
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11.Risk of psychiatric disorders following gastroesophageal reflux disease: A nationwide population-based cohort study.
You ZH, Perng CL, Hu LY, Lu T, Chen PM, Yang AC, Tsai SJ, Huang YS, Chen HJ.
Eur J Intern Med. 2015 Sep;26(7):534-9. doi: 10.1016/j.ejim.2015.05.005. Epub 2015 May 26.
PMID: 26021838 [PubMed – in process]
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12.Patients with refractory reflux symptoms: What do they have and how should they be managed?
Kahrilas PJ, Keefer L, Pandolfino JE.
Neurogastroenterol Motil. 2015 Sep;27(9):1195-201. doi: 10.1111/nmo.12644.
PMID: 26303047 [PubMed – in process]
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