Is Ankylosing Spondylitis due to a Chronic Infection? New Targets in Autoimmune Disease

We will be starting a new series termed “New Targets in Autoimmune Disease.”  In this series we will be focusing on relationships between diet, gut health, and chronic infections in the body that may be propagating autoimmune diseases.  We will likely cover diseases such as RA again, but also go into Crohns, Ulcerative Colitis, Autoimmune Hepatitis, and Psoriasis to name a few.  Today we are specifically talking about Ankylosing Spondylitis, a condition where the joints of the spine fuse due to the immune system attacking these joints. In today’s broadcast we will be covering how certain organisms in the gastrointestinal tract are associated with this condition, and what scientists and doctors are doing to get to the underlying causes.
Please forward us any questions here on our website or go to our Power Health Facebook page http://powerhealthreno.com/Facebook
References:
1. Migraine associated with gastrointestinal disorders: review of the literature and clinical implications.
van Hemert S, Breedveld AC, Rovers JM, Vermeiden JP, Witteman BJ, Smits MG, de Roos NM.
Front Neurol. 2014 Nov 21;5:241. doi: 10.3389/fneur.2014.00241. eCollection 2014. Review.
PMID: 25484876 [PubMed] Free PMC Article
Similar articles
2. The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study.
de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S.
Benef Microbes. 2015 Apr 13:1-6. [Epub ahead of print]
PMID: 25869282 [PubMed – as supplied by publisher]
Similar articles
3. Raised incidence of ankylosing spondylitis among Inuit populations could be due to high HLA-B27 association and starch consumption.
Rashid T, Wilson C, Ebringer A.
Rheumatol Int. 2015 Jun;35(6):945-51. doi: 10.1007/s00296-014-3164-2. Epub 2014 Nov 11.
PMID: 25385438 [PubMed – in process]
Similar articles
4. The link between ankylosing spondylitis, Crohn’s disease, Klebsiella, and starch consumption.
Rashid T, Wilson C, Ebringer A.
Clin Dev Immunol. 2013;2013:872632. doi: 10.1155/2013/872632. Epub 2013 May 27. Review.
PMID: 23781254 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
5. Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera.
Welsh J, Avakian H, Cowling P, Ebringer A, Wooley P, Panayi G, Ebringer R.
Br J Exp Pathol. 1980 Feb;61(1):85-91.
PMID: 6769456 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
6. Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera.
Avakian H, Welsh J, Ebringer A, Entwistle CC.
Br J Exp Pathol. 1980 Feb;61(1):92-6.
PMID: 6990955 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
7. Identification of HLA-B27M1 and -M2 cross-reactive antigens in Klebsiella, Shigella and Yersinia.
van Bohemen CG, Grumet FC, Zanen HC.
Immunology. 1984 Aug;52(4):607-10. No abstract available.
PMID: 6378768 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
8. Mimicry of human histocompatibility HLA-B27 antigens by Klebsiella pneumoniae.
Ogasawara M, Kono DH, Yu DT.
Infect Immun. 1986 Mar;51(3):901-8.
PMID: 3512439 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
9. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter’s syndrome. Molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease.
Schwimmbeck PL, Yu DT, Oldstone MB.
J Exp Med. 1987 Jul 1;166(1):173-81.
PMID: 2439632 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
10. Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae.
Fielder M, Pirt SJ, Tarpey I, Wilson C, Cunningham P, Ettelaie C, Binder A, Bansal S, Ebringer A.
FEBS Lett. 1995 Aug 7;369(2-3):243-8.
PMID: 7649265 [PubMed – indexed for MEDLINE] Free Article
Similar articles
11. The use of enzyme immunoassay (EIA) and radiobinding assay to investigate the cross-reactivity of Klebsiella antigens and HLA B27 in ankylosing spondylitis patients and healthy controls.
Baines M, Ebringer A, Avakian H, Samuel D, James DC.
Scand J Rheumatol. 1990;19(5):341-9.
PMID: 1699267 [PubMed – indexed for MEDLINE]
Similar articles
12. IgM, IgG and IgA class enterobacterial antibodies in serum and synovial fluid in patients with ankylosing spondylitis and rheumatoid arthritis.
Mäki-Ikola O, Penttinen M, Von Essen R, Gripenberg-Lerche C, Isomäki H, Granfors K.
Br J Rheumatol. 1997 Oct;36(10):1051-3.
PMID: 9374920 [PubMed – indexed for MEDLINE] Free Article
Similar articles
13. Cross-reactive epitope with Klebsiella pneumoniae nitrogenase in articular tissue of HLA-B27+ patients with ankylosing spondylitis.
Husby G, Tsuchiya N, Schwimmbeck PL, Keat A, Pahle JA, Oldstone MB, Williams RC Jr.
Arthritis Rheum. 1989 Apr;32(4):437-45.
PMID: 2468338 [PubMed – indexed for MEDLINE]
Similar articles
14. Ankylosing spondylitis: klebsiella and HL-A B27.
Ebringer R, Cooke D, Cawdell DR, Cowling P, Ebringer A.
Rheumatol Rehabil. 1977 Aug;16(3):190-6.
PMID: 910095 [PubMed – indexed for MEDLINE]
Similar articles
15. Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease.
Eastmond CJ, Willshaw HE, Burgess SE, Shinebaum R, Cooke EM, Wright V.
Ann Rheum Dis. 1980 Apr;39(2):118-23.
PMID: 6992718 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
16. Fecal carriage of various Klebsiella and Enterobacter species in patients with active ankylosing spondylitis.
Hunter T, Harding GK, Kaprove RE, Schroeder ML.
Arthritis Rheum. 1981 Jan;24(1):106-8. No abstract available.
PMID: 7470165 [PubMed – indexed for MEDLINE]
Similar articles
17. Association of gut inflammation with increased serum IgA class Klebsiella antibody concentrations in patients with axial ankylosing spondylitis (AS): implication for different aetiopathogenetic mechanisms for axial and peripheral AS?
Mäki-Ikola O, Leirisalo-Repo M, Turunen U, Granfors K.
Ann Rheum Dis. 1997 Mar;56(3):180-3.
PMID: 9135221 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
18. Gut inflammation in the spondyloarthropathies.
Mielants H, De Keyser F, Baeten D, Van den Bosch F.
Curr Rheumatol Rep. 2005 Jun;7(3):188-94. Review.
PMID: 15918994 [PubMed – indexed for MEDLINE]
Similar articles
19. Genetics in twins with Crohn’s disease: less pronounced than previously believed?
Halfvarson J.
Inflamm Bowel Dis. 2011 Jan;17(1):6-12. doi: 10.1002/ibd.21295.
PMID: 20848478 [PubMed – indexed for MEDLINE]
Similar articles
20. Incidence of Crohn’s disease and CARD15 mutation in a small township in Sicily.
Cottone M, Renda MC, Mattaliano A, Oliva L, Fries W, Criscuoli V, Modesto I, Scimeca D, Maggio A, Casà A, Maisano S, Mocciaro F, Sferrazza A, Orlando A.
Eur J Epidemiol. 2006;21(12):887-92. Epub 2006 Dec 8.
PMID: 17160430 [PubMed – indexed for MEDLINE]
Similar articles
21. Epidemiology and natural history of inflammatory bowel diseases.
Cosnes J, Gower-Rousseau C, Seksik P, Cortot A.
Gastroenterology. 2011 May;140(6):1785-94. doi: 10.1053/j.gastro.2011.01.055.
PMID: 21530745 [PubMed – indexed for MEDLINE]
Similar articles
22. Effect of antibiotics on bacterial flora of rats with intestinal blind loops.
Kent TH, Summers RW, DenBesten L, Swaner JC, Hrouda M.
Proc Soc Exp Biol Med. 1969 Oct;132(1):63-7. No abstract available.
PMID: 4310178 [PubMed – indexed for MEDLINE]
Similar articles
23. Role of intestinal microflora in chronic inflammation and ulceration of the rat colon.
Videla S, Vilaseca J, Guarner F, Salas A, Treserra F, Crespo E, Antolín M, Malagelada JR.
Gut. 1994 Aug;35(8):1090-7.
PMID: 7926912 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
24. Role of Klebsiella and collagens in Crohn’s disease: a new prospect in the use of low-starch diet.
Rashid T, Ebringer A, Tiwana H, Fielder M.
Eur J Gastroenterol Hepatol. 2009 Aug;21(8):843-9. doi: 10.1097/MEG.0b013e328318ecde. Review.
PMID: 19352192 [PubMed – indexed for MEDLINE]
Similar articles
25. Frequency and spectrum of microorganisms isolated from biopsy specimens in chronic colitis.
Höring E, Göpfert D, Schröter G, von Gaisberg U.
Endoscopy. 1991 Nov;23(6):325-7.
PMID: 1778136 [PubMed – indexed for MEDLINE]
Similar articles
26. [Intercurrent Klebsiella oxytoca colitis in a patient with Crohn’s disease].
Plessier A, Cosnes J, Gendre JP, Beaugerie L.
Gastroenterol Clin Biol. 2002 Aug-Sep;26(8-9):799-800. French. No abstract available.
PMID: 12434087 [PubMed – indexed for MEDLINE] Free Article
Similar articles

Leave a Comment

Your email address will not be published. Required fields are marked *

*

This site uses Akismet to reduce spam. Learn how your comment data is processed.