Irritable Bowel Syndrome: Should It Be Called Irritable Brain Syndrome?

Irritable Bowel Syndrome, known as IBS, is an extremely common condition affecting upwards of 20% of the population.  Many patients with IBS become frustrated by limiting diets, poor response to supplements, and that their condition is not deemed to be that serious even though the symptoms can make social situations very awkward and stressful.  In today’s broadcast we will discuss how the scientific literature is shifting its opinion on IBS as being primarily a neurological problem rather than a gut problem.
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1.Neuroendocrine markers and psychological features in patients with irritable bowel syndrome.
Stasi C, Bellini M, Costa F, Mumolo MG, Ricchiuti A, Grosso M, Duranti E, Metelli MR, Gambaccini D, Bianchi L, Di Tanna GL, Laffi G, Taddei S, Marchi S.
Int J Colorectal Dis. 2013 Sep;28(9):1203-8. doi: 10.1007/s00384-013-1646-4. Epub 2013 Feb 2.
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2.The effects of an acute serotonergic challenge on brain-gut responses in irritable bowel syndrome patients and controls.
Kilkens TO, Honig A, Fekkes D, Brummer RJ.
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3.Irritable bowel syndrome: Is it “irritable brain” or “irritable bowel”?
Padhy SK, Sahoo S, Mahajan S, Sinha SK.
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4.Activation of corticotropin-releasing factor neurons and microglia in paraventricular nucleus precipitates visceral hypersensitivity induced by colorectal distension in rats.
Zhang G, Yu L, Chen ZY, Zhu JS, Hua R, Qin X, Cao JL, Zhang YM.
Brain Behav Immun. 2015 Dec 29. pii: S0889-1591(15)30084-2. doi: 10.1016/j.bbi.2015.12.022. [Epub ahead of print]
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5.Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study.
Chen CH, Lin CL, Kao CH.
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6.Irritable Bowel Syndrome: A Clinical Review.
Cashman MD, Sonu Dhillon DK, Puli SR.
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7.Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis.
Wiley JW, Higgins GA, Athey BD.
Neurogastroenterol Motil. 2016 Jan;28(1):12-25. doi: 10.1111/nmo.12706. Review.
PMID: 26690871 [PubMed – in process]
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8.Gastrointestinal Parasites and the Neural Control of Gut Functions.
Halliez MC, Buret AG.
Front Cell Neurosci. 2015 Nov 25;9:452. doi: 10.3389/fncel.2015.00452. eCollection 2015. Review.
PMID: 26635531 [PubMed] Free PMC Article
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9.Topological Reorganization of the Default Mode Network in Irritable Bowel Syndrome.
Qi R, Ke J, Schoepf UJ, Varga-Szemes A, Milliken CM, Liu C, Xu Q, Wang F, Zhang LJ, Lu GM.
Mol Neurobiol. 2015 Dec 3. [Epub ahead of print]
PMID: 26635086 [PubMed – as supplied by publisher]
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10.Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases.
Ghaisas S, Maher J, Kanthasamy A.
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PMID: 26627987 [PubMed – as supplied by publisher]
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11.Is there a causal link between psychological disorders and functional gastrointestinal disorders?
Wouters MM, Boeckxstaens GE.
Expert Rev Gastroenterol Hepatol. 2016 Jan;10(1):5-8. doi: 10.1586/17474124.2016.1109446. Epub 2015 Nov 16.
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12.Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety and depression.
Qi R, Liu C, Ke J, Xu Q, Zhong J, Wang F, Zhang LJ, Lu GM.
Brain Imaging Behav. 2015 Nov 10. [Epub ahead of print]
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13.Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats.
Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
Neurogastroenterol Motil. 2015 Dec 10. doi: 10.1111/nmo.12747. [Epub ahead of print]
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14.Excessive coupling of the salience network with intrinsic neurocognitive brain networks during rectal distension in adolescents with irritable bowel syndrome: a preliminary report.
Liu X, Silverman A, Kern M, Ward BD, Li SJ, Shaker R, Sood MR.
Neurogastroenterol Motil. 2016 Jan;28(1):43-53. doi: 10.1111/nmo.12695. Epub 2015 Oct 14.
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15.Comparing the Areas of Interest in the Field of Functional Gastrointestinal Disorder and Neurogastroenterology and Motility Between the East and the West.
Lee JY, Kim N, Kim GH, Kim GH.
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16.The role of mast cells in functional GI disorders.
Wouters MM, Vicario M, Santos J.
Gut. 2016 Jan;65(1):155-68. doi: 10.1136/gutjnl-2015-309151. Epub 2015 Jul 20. Review.
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17.Potential Causes and Present Pharmacotherapy of Irritable Bowel Syndrome: An Overview.
Bokic T, Storr M, Schicho R.
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18.Irritable bowel syndrome: an integrated explanatory model for clinical practice.
Hungin AP, Becher A, Cayley B, Heidelbaugh JJ, Muris JW, Rubin G, Seifert B, Russell A, De Wit NJ.
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19.Corticotrophin-releasing factor 1 activation in the central amygdale and visceral hyperalgesia.
Taché Y.
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20.Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction.
Hyland NP, O’Mahony SM, O’Malley D, O’Mahony CM, Dinan TG, Cryan JF.
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21.The quest for biomarkers in IBS-where should it lead us?
Corsetti M, Van Oudenhove L, Tack J.
Neurogastroenterol Motil. 2014 Dec;26(12):1669-76. doi: 10.1111/nmo.12475. Review.
PMID: 25424580 [PubMed – indexed for MEDLINE]
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