Hyperhidrosis: Solutions for Sweaty Hands, Feet, and Axillas

Today we are discussing hyperhidrosis, which is a rather common problem in our society affecting approximately 5-10% of the population.  This can be a disabling condition that induces social anxiety for fear of what others will think a sweaty palm when shaking hands.  In today’s broadcast we will cover current treatments for this condition and other non drug modalities the hyperhidrosis patient should be aware of.
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1.Video-Assisted Thoracoscopic Sympathectomy for Palmar Hyperhidrosis: A Meta-Analysis of Randomized Controlled Trials.
Zhang W, Yu D, Jiang H, Xu J, Wei Y.
PLoS One. 2016 May 17;11(5):e0155184. doi: 10.1371/journal.pone.0155184. eCollection 2016.
PMID: 27187774 [PubMed – in process] Free Article
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2.Comparisons of the clinical outcomes of thoracoscopic sympathetic surgery for palmar hyperhidrosis: R4 sympathicotomy versus R4 sympathetic clipping versus R3 sympathetic clipping.
Joo S, Lee GD, Haam S, Lee S.
J Thorac Dis. 2016 May;8(5):934-41. doi: 10.21037/jtd.2016.03.57.
PMID: 27162669 [PubMed] Free PMC Article
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3.The efficacy of oral anticholinergics for sympathetic overactivity in a thoracic surgery clinic.
Hynes CF, Seevaratnam S, Gesuwan K, Margolis M, Marshall MB.
J Thorac Cardiovasc Surg. 2016 Apr 14. pii: S0022-5223(16)30115-5. doi: 10.1016/j.jtcvs.2016.03.092. [Epub ahead of print]
PMID: 27160942 [PubMed – as supplied by publisher]
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4.Innovative use of chemodenervation in the treatment of postoperative genital hyperhidrosis-like symptoms.
Stiegel KR, Bahrani E, Markus RF.
Dermatol Online J. 2016 Mar 16;22(3). pii: 13030/qt99g4q4d8.
PMID: 27136635 [PubMed – in process] Free Article
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5.Anatomical variation of rami communicantes in the upper thoracic sympathetic chain: A human cadaveric study.
Street E, Ashrafi M, Greaves N, Gouldsborough I, Baguneid M.
Ann Vasc Surg. 2016 Apr 23. pii: S0890-5096(16)30168-6. doi: 10.1016/j.avsg.2016.04.001. [Epub ahead of print]
PMID: 27116906 [PubMed – as supplied by publisher]
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6.Radiofrequency Thermotherapy for Treating Axillary Hyperhidrosis.
Schick CH, Grallath T, Schick KS, Hashmonai M.
Dermatol Surg. 2016 May;42(5):624-30. doi: 10.1097/DSS.0000000000000703.
PMID: 27110892 [PubMed – in process]
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7.Hyperhidrosis Prevalence and Demographical Characteristics in Dermatology Outpatients in Shanghai and Vancouver.
Liu Y, Bahar R, Kalia S, Huang RY, Phillips A, Su M, Yang S, Zhang X, Zhou P, Zhou Y.
PLoS One. 2016 Apr 22;11(4):e0153719. doi: 10.1371/journal.pone.0153719. eCollection 2016.
PMID: 27105064 [PubMed – in process] Free PMC Article
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8.Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
Abtahi-Naeini B, Naeini FF, Saffaei A, Behfar S, Pourazizi M, Mirmohammadkhani M, Bolandnazar NS.
Indian J Dermatol. 2016 Mar-Apr;61(2):234. doi: 10.4103/0019-5154.177789.
PMID: 27057039 [PubMed] Free PMC Article
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9.Familial secondary hyperhidrosis associated with tumor necrosis factor-alpha inhibitor treatment.
Ikediobi O, Chen YC, Shinkai K.
JAAD Case Rep. 2015 Nov 26;1(6):418-20. doi: 10.1016/j.jdcr.2015.10.012. eCollection 2015 Nov. No abstract available.
PMID: 27051797 [PubMed] Free PMC Article
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10.[Effect of T4 thoracoscopic sympathectomy on ?plantar hyperhidrosis in patients with ?primary palmoplantar hyperhidrosis].
Xiao P, Liu A, Liu W.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Mar 28;41(3):300-4. doi: 10.11817/j.issn.1672-7347.2016.03.012. Chinese.
PMID: 27033795 [PubMed – in process] Free Article
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11.Oral oxybutynin for the treatment of hyperhidrosis: outcomes after one-year follow-up.
Millán-Cayetano JF, Del Boz J, Rivas-Ruiz F, Blázquez-Sánchez N, Hernández Ibáñez C, de Troya-Martín M.
Australas J Dermatol. 2016 Mar 30. doi: 10.1111/ajd.12473. [Epub ahead of print]
PMID: 27029500 [PubMed – as supplied by publisher]
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12.Quality of life and social isolation in Greek adolescents with primary focal hyperhidrosis treated with botulinum toxin type A: a case series.
Kouris A, Armyra K, Stefanaki C, Christodoulou C, Karimali P, Kontochristopoulos G.
Pediatr Dermatol. 2015 Mar-Apr;32(2):226-30. doi: 10.1111/pde.12480. Epub 2014 Dec 29.
PMID: 25557249 [PubMed – indexed for MEDLINE]
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13.Fractionated microneedle radiofrequency for treatment of primary axillary hyperhidrosis: A sham control study.
Fatemi Naeini F, Abtahi-Naeini B, Pourazizi M, Nilforoushzadeh MA, Mirmohammadkhani M.
Australas J Dermatol. 2015 Nov;56(4):279-84. doi: 10.1111/ajd.12260. Epub 2014 Dec 13.
PMID: 25496000 [PubMed – in process]
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14.Elevated social stress levels and depressive symptoms in primary hyperhidrosis.
Gross KM, Schote AB, Schneider KK, Schulz A, Meyer J.
PLoS One. 2014 Mar 19;9(3):e92412. doi: 10.1371/journal.pone.0092412. eCollection 2014.
PMID: 24647796 [PubMed – indexed for MEDLINE] Free PMC Article
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15.Sweaty skin, background and assessments.
Noël F, Piérard-Franchimont C, Piérard GE, Quatresooz P.
Int J Dermatol. 2012 Jun;51(6):647-55. doi: 10.1111/j.1365-4632.2011.05307.x. Review.
PMID: 22607280 [PubMed – indexed for MEDLINE]
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16.Prevalence of hyperhidrosis among medical students.
Westphal FL, de Carvalho MA, Lima LC, de Carvalho BC, Padilla R, Araújo KK.
Rev Col Bras Cir. 2011 Nov-Dec;38(6):392-7. English, Portuguese.
PMID: 22267136 [PubMed – indexed for MEDLINE] Free Article
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17.Evaluation of trace elements, calcium, and magnesium levels in the plasma and erythrocytes of patients with essential hyperhidrosis.
Güder H, Karaca S, Cemek M, Kulaç M, Güder S.
Int J Dermatol. 2011 Sep;50(9):1071-4. doi: 10.1111/j.1365-4632.2010.04862.x.
PMID: 22126867 [PubMed – indexed for MEDLINE]
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18.Edema due to altered sweating function.
Tanaka M, Shimizu H, Monden T, Mori M.
J Med. 1993;24(2-3):203-8.
PMID: 8409783 [PubMed – indexed for MEDLINE]
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19.[Isaacs’s syndrome and associated diseases].
Watanabe O.
Rinsho Shinkeigaku. 2013;53(11):1067-70. Review. Japanese.
PMID: 24291881 [PubMed – indexed for MEDLINE]
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20.Chronic pain as a manifestation of potassium channel-complex autoimmunity.
Klein CJ, Lennon VA, Aston PA, McKeon A, Pittock SJ.
Neurology. 2012 Sep 11;79(11):1136-44. doi: 10.1212/WNL.0b013e3182698cab. Epub 2012 Aug 15.
PMID: 22895588 [PubMed – indexed for MEDLINE] Free PMC Article
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21.Skin disorders and thyroid diseases.
Niepomniszcze H, Amad RH.
J Endocrinol Invest. 2001 Sep;24(8):628-38. Review.
PMID: 11686547 [PubMed – indexed for MEDLINE]
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22.Plantar Hyperhidrosis: An Overview.
Vlahovic TC.
Clin Podiatr Med Surg. 2016 Jul;33(3):441-51. doi: 10.1016/j.cpm.2016.02.010. Epub 2016 Mar 26. Review.
PMID: 27215162 [PubMed – in process]
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23.[Treatment of hyperhidrosis (excessive sweating)].
Salava A, Jousimaa J.
Duodecim. 2016;132(3):247-52. Review. Finnish.
PMID: 26951029 [PubMed – indexed for MEDLINE]
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24.Overexpression of AQP5 Was Detected in Axillary Sweat Glands of Primary Focal Hyperhidrosis Patients.
Du Q, Lin M, Yang JH, Chen JF, Tu YR.
Dermatology. 2016;232(2):150-5. doi: 10.1159/000444081. Epub 2016 Mar 2.
PMID: 26930592 [PubMed – in process]
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25.Focal hyperhidrosis secondary to eccrine naevus successfully treated with botulinum toxin type A.
Lera M, España A, Idoate MÁ.
Clin Exp Dermatol. 2015 Aug;40(6):640-3. doi: 10.1111/ced.12608. Epub 2015 Mar 28.
PMID: 25816711 [PubMed – indexed for MEDLINE]
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