Hashimoto’s Thyroiditis and Brain Fog: Is It More Than a Thyroid Problem?

Today we will be discussing brain fog, which is a symptom we see often in our clinic for patients who have Hashimoto’s thyroiditis but also fibromyalgia and mast cell activation disorders.  In today’s broadcast we will discuss the most recent research on why autoimmune thyroid patients may have brain fog.

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1.Cognitive and affective dysfunctions in autoimmune thyroiditis.
Leyhe T, Müssig K.
Brain Behav Immun. 2014 Oct;41:261-6. doi: 10.1016/j.bbi.2014.03.008. Epub 2014 Mar 29. Review.
PMID: 24685840 [PubMed – indexed for MEDLINE]
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2.What is brain fog? An evaluation of the symptom in postural tachycardia syndrome.
Ross AJ, Medow MS, Rowe PC, Stewart JM.
Clin Auton Res. 2013 Dec;23(6):305-11. doi: 10.1007/s10286-013-0212-z. Epub 2013 Sep 3.
PMID: 23999934 [PubMed – indexed for MEDLINE] Free PMC Article
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3.Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.
Theoharides TC, Stewart JM, Hatziagelaki E, Kolaitis G.
Front Neurosci. 2015 Jul 3;9:225. doi: 10.3389/fnins.2015.00225. eCollection 2015. Review.
PMID: 26190965 [PubMed] Free PMC Article
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4.Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome.
Ocon AJ.
Front Physiol. 2013 Apr 5;4:63. doi: 10.3389/fphys.2013.00063. eCollection 2013.
PMID: 23576989 [PubMed] Free PMC Article
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5.Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity.
Lichtwark IT, Newnham ED, Robinson SR, Shepherd SJ, Hosking P, Gibson PR, Yelland GW.
Aliment Pharmacol Ther. 2014 Jul;40(2):160-70. doi: 10.1111/apt.12809. Epub 2014 May 28.
PMID: 24889390 [PubMed – indexed for MEDLINE] Free Article
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6.Fibrofog and fibromyalgia: a narrative review and implications for clinical practice.
Kravitz HM, Katz RS.
Rheumatol Int. 2015 Jul;35(7):1115-25. doi: 10.1007/s00296-014-3208-7. Epub 2015 Jan 13. Review.
PMID: 25583051 [PubMed – indexed for MEDLINE]
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7.Cross-sectional neurocognitive data do not support a transition from fibrofog to Alzheimer disease in fibromyalgia patients.
Leavitt F, Katz RS.
J Clin Rheumatol. 2015 Mar;21(2):81-5. doi: 10.1097/RHU.0000000000000213.
PMID: 25710859 [PubMed – indexed for MEDLINE]
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8.Exercise, fibromyalgia, and fibrofog: a pilot study.
Etnier JL, Karper WB, Gapin JI, Barella LA, Chang YK, Murphy KJ.
J Phys Act Health. 2009 Mar;6(2):239-46.
PMID: 19420402 [PubMed – indexed for MEDLINE]
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9.[Cognitive impairment in patients suffering from fibromyalgia. An underestimated problem].
Schmidt-Wilcke T, Wood P, Lürding R.
Schmerz. 2010 Feb;24(1):46-53. doi: 10.1007/s00482-009-0872-8. Review. German.
PMID: 20108102 [PubMed – indexed for MEDLINE]
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10.A Comparison of Fibromyalgia Symptoms in Patients with Healthy versus Depressive, Low and Reactive Affect Balance Styles.
Toussaint LL, Vincent A, McAllister SJ, Oh TH, Hassett AL.
Scand J Pain. 2014 Mar 1;5(3):161-166.
PMID: 25067981 [PubMed] Free PMC Article
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11.Gluten-induced cognitive impairment (“brain fog”) in coeliac disease.
Yelland GW.
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:90-93. doi: 10.1111/jgh.13706. Review.
PMID: 28244662 [PubMed – in process]
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12.Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?
Yalcin MM, Altinova AE, Cavnar B, Bolayir B, Akturk M, Arslan E, Ozkan C, Cakir N, Balos Toruner F.
Endocr J. 2017 Apr 29;64(4):425-429. doi: 10.1507/endocrj.EJ16-0418. Epub 2017 Mar 4.
PMID: 28260699 [PubMed – in process] Free Article
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13.A pattern of cerebral perfusion anomalies between major depressive disorder and Hashimoto thyroiditis.
Hardoy MC, Cadeddu M, Serra A, Moro MF, Mura G, Mellino G, Bhat KM, Altoé G, Usai P, Piga M, Carta MG.
BMC Psychiatry. 2011 Sep 13;11:148. doi: 10.1186/1471-244X-11-148.
PMID: 21910915 [PubMed – indexed for MEDLINE] Free PMC Article
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14.Increased prevalence of sublinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto’s encephalitis?
Zettinig G, Asenbaum S, Fueger BJ, Hofmann A, Diemling M, Mittlboeck M, Dudczak R.
Clin Endocrinol (Oxf). 2003 Nov;59(5):637-43.
PMID: 14616889 [PubMed – indexed for MEDLINE]
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