The research is exciting in regards to the underlying causes of autoimmune thyroid disease. In today’s broadcast we will discuss new insights into how EBV may be triggering the immune system to attack the thyroid.
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References:
1. | The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases. |
Janegova A, Janega P, Rychly B, Kuracinova K, Babal P. | |
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2. | [Risk factors and pathogenesis of Hashimoto’s thyroiditis]. |
Paknys G, Kondrotas AJ, Kevelaitis E. | |
Medicina (Kaunas). 2009;45(7):574-83. Review. Lithuanian. | |
PMID: 19667753 [PubMed – indexed for MEDLINE] Free Article | |
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3. | Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves’ Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation. |
Kumata K, Nagata K, Matsushita M, Kuwamoto S, Kato M, Murakami I, Fukata S, Hayashi K. | |
Viral Immunol. 2016 Oct;29(8):459-463. Epub 2016 Aug 16. | |
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4. | Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface. |
Nagata K, Nakayama Y, Higaki K, Ochi M, Kanai K, Matsushita M, Kuwamoto S, Kato M, Murakami I, Iwasaki T, Nanba E, Kimura H, Hayashi K. | |
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5. | Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves’ disease patients and in healthy individuals. |
Nagata K, Higaki K, Nakayama Y, Miyauchi H, Kiritani Y, Kanai K, Matsushita M, Iwasaki T, Sugihara H, Kuwamoto S, Kato M, Murakami I, Nanba E, Kimura H, Hayashi K. | |
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6. | CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. |
Pender MP. | |
Autoimmune Dis. 2012;2012:189096. doi: 10.1155/2012/189096. Epub 2012 Jan 24. | |
PMID: 22312480 [PubMed] Free PMC Article | |
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7. | Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation. |
Palmer CD, Romero-Tejeda M, Sirignano M, Sharma S, Allen TM, Altfeld M, Jost S. | |
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8. | Infections and autoimmune thyroid diseases: parallel detection of antibodies against pathogens with proteomic technology. |
Tozzoli R, Barzilai O, Ram M, Villalta D, Bizzaro N, Sherer Y, Shoenfeld Y. | |
Autoimmun Rev. 2008 Dec;8(2):112-5. doi: 10.1016/j.autrev.2008.07.013. | |
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9. | Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases. |
Sultanova A, Cistjakovs M, Gravelsina S, Chapenko S, Roga S, Cunskis E, Nora-Krukle Z, Groma V, Ventina I, Murovska M. | |
Clin Microbiol Infect. 2016 Sep 29. pii: S1198-743X(16)30429-3. doi: 10.1016/j.cmi.2016.09.023. | |
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10. | Increase in Peripheral CD3-CD56brightCD16- Natural Killer Cells in Hashimoto’s Thyroiditis Associated with HHV-6 Infection. |
Rizzo R, Zatelli MC, Rotola A, Cassai E, Degli Uberti E, Di Luca D, Caselli E. | |
Adv Exp Med Biol. 2016;897:113-20. doi: 10.1007/5584_2015_5010. | |
PMID: 26566646 [PubMed – indexed for MEDLINE] | |
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11. | Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto’s thyroiditis. |
Caselli E, Zatelli MC, Rizzo R, Benedetti S, Martorelli D, Trasforini G, Cassai E, degli Uberti EC, Di Luca D, Dolcetti R. | |
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12. | Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein-Barr virus primary infection: a case report of a child. |
Nagata K, Okuno K, Ochi M, Kumata K, Sano H, Yoneda N, Ueyama J, Matsushita M, Kuwamoto S, Kato M, Murakami I, Kanzaki S, Hayashi K. | |
Springerplus. 2015 Aug 27;4:456. doi: 10.1186/s40064-015-1236-8. eCollection 2015. | |
PMID: 26322262 [PubMed] Free PMC Article | |
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