Hashimoto’s, Hypothyroidism and Risk of Miscarriage

In today’s broadcast we will be further exploring relationships between thyroid disorders and miscarriage. Specifically we will be discussing current concepts regarding more stringent criteria for TSH evaluation in pregnant females, the role of thyroid antibodies alone in affecting recurrent miscarriages, and novel treatments for these issues.

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References:
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2.Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies.
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8.Treatment of recurrent pregnancy loss by Levothyroxine in women with high Anti-TPO antibody.
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9.Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life.
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10.Positive thyroid peroxidase antibody titer is associated with dysphoric moods during pregnancy and postpartum.
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11.Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort.
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12.Women with Subclinical Hypothyroidism Are at Low Risk of Poor Pregnancy Outcome in Japan.
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13.Prevalence of Thyroid Peroxidase Antibody and Pregnancy Outcome in Euthyroid Autoimmune Positive Pregnant Women from a Tertiary Care Center in Haryana.
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14.Outcome of in vitro fertilization in women with subclinical hypothyroidism.
Cai Y, Zhong L, Guan J, Guo R, Niu B, Ma Y, Su H.
Reprod Biol Endocrinol. 2017 May 25;15(1):39. doi: 10.1186/s12958-017-0257-2.
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15.PROGNOSTIC RISK OF OBSTETRIC AND PERINATAL COMPLICATIONS IN PREGNANT WOMEN WITH THYROID DYSFUNCTION.
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16.A Retrospective Study on the Association between Thyroid Autoantibodies with ?2-glycoprotein and Cardiolipin Antibodies in Recurrent Miscarriage.
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17.Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: A systematic review and meta-analysis.
Zhang Y, Wang H, Pan X, Teng W, Shan Z.
PLoS One. 2017 Apr 17;12(4):e0175708. doi: 10.1371/journal.pone.0175708. eCollection 2017. Review.
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18.Effects of Levothyroxine on Pregnancy Outcomes in Women With Thyroid Dysfunction: A Meta-analysis of Randomized Controlled Trials.
Li J, Shen J, Qin L.
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19.Correlation of enhanced oxidative stress with altered thyroid profile: Probable role in spontaneous abortion.
Ramandeep K, Kapil G, Harkiran K.
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PMID: 28251103 [PubMed – in process] Free PMC Article
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20.Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease.
Nazarpour S, Ramezani Tehrani F, Simbar M, Tohidi M, Alavi Majd H, Azizi F.
Eur J Endocrinol. 2017 Feb;176(2):253-265. doi: 10.1530/EJE-16-0548. Epub 2016 Nov 22.
PMID: 27879326 [PubMed – indexed for MEDLINE]
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