Genetic Associations With Anxiety and Depression

Today we are discussing genetics and their associations to depression as well as anxiety. With the mapping of the human genome significant information has come to the surface regarding convergent functional genomics and the interplay between these and environment. We hope that you find today’s broadcast informative.

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1.What do the genetic association data say about the high risk of suicide in people with depression? A novel network-based approach to find common molecular basis for depression and suicidal behavior and related therapeutic targets.
Bozorgmehr A, Alizadeh F, Ofogh SN, Hamzekalayi MRA, Herati S, Moradkhani A, Shahbazi A, Ghadirivasfi M.
J Affect Disord. 2018 Jan 8;229:463-468. doi: 10.1016/j.jad.2017.12.079. [Epub ahead of print]
PMID: 29331709 [PubMed – as supplied by publisher]
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2.Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.
Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR.
Mol Psychiatry. 2015 Nov;20(11):1266-85. doi: 10.1038/mp.2015.112. Epub 2015 Aug 18.
PMID: 26283638 [PubMed – indexed for MEDLINE] Free PMC Article
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3.Discovery and validation of blood biomarkers for suicidality.
Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB 3rd.
Mol Psychiatry. 2013 Dec;18(12):1249-64. doi: 10.1038/mp.2013.95. Epub 2013 Aug 20.
PMID: 23958961 [PubMed – indexed for MEDLINE] Free PMC Article
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4.[Folates in the treatment of depression].
Erbe S, Pellert UN.
Fortschr Neurol Psychiatr. 2014 Feb;82(2):78-83. doi: 10.1055/s-0033-1356123. Epub 2014 Feb 11. Review. German.
PMID: 24519190 [PubMed – indexed for MEDLINE]
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5.Methylenetetrahydrofolate Reductase A1298C Polymorphism and Major Depressive Disorder.
Cho K, Amin ZM, An J, Rambaran KA, Johnson TB, Alzghari SK.
Cureus. 2017 Oct 1;9(10):e1734. doi: 10.7759/cureus.1734. Review.
PMID: 29209581 [PubMed] Free PMC Article
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6.Association of C677T polymorphism (rs1801133) in MTHFR gene with depression.
Rai V.
Cell Mol Biol (Noisy-le-grand). 2017 Jul 31;63(6):60-67. doi: 10.14715/cmb/2017.63.6.13.
PMID: 28968218 [PubMed – in process]
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7.The C677T variant in <i>MTHFR</i> modulates associations between brain integrity, mood, and cognitive functioning in old age.
Roussotte FF, Hua X, Narr KL, Small GW, Thompson PM; Alzheimer’s Disease Neuroimaging Initiative.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Apr;2(3):280-288. doi: 10.1016/j.bpsc.2016.09.005.
PMID: 28435933 [PubMed] Free Article
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