Fibromyalgia: Association with Decreased Grey Matter in the Brain

Today we will be discussing fibromyalgia and its associations with alterations in grey matter density in the brain.  We will discuss the scientific literature on this topic highlighting how some areas of the brain will have increased grey matter while other areas have decreased grey matter, leading researchers to speculate that this is either a cause or effect of the disorder.  We will present this information with our clinical experience as well as highlighting other phenomena documented in the fibromyalgia patient population that may be contributing to these findings.
Please forward us any comments here on our website or go to our Power Health Facebook page
1.Gray matter abnormalities associated with fibromyalgia: A meta-analysis of voxel-based morphometric studies.
Shi H, Yuan C, Dai Z, Ma H, Sheng L.
Semin Arthritis Rheum. 2016 Dec;46(3):330-337. doi: 10.1016/j.semarthrit.2016.06.002.
PMID: 27989500 [Unknown status]
Similar articles
2.The social construction of fibromyalgia as a health problem from the perspective of policies, professionals, and patients.
Briones-Vozmediano E.
Glob Health Action. 2016 Dec 19;9:31967. doi: 10.3402/gha.v9.31967.
PMID: 27989274 [Unknown status] Free Article
Similar articles
3.Histological underpinnings of grey matter changes in fibromyalgia investigated using multimodal brain imaging.
Pomares FB, Funck T, Feier NA, Roy S, Daigle-Martel A, Ceko M, Narayanan S, Araujo D, Thiel A, Stikov N, Fitzcharles MA, Schweinhardt P.
J Neurosci. 2016 Dec 16. pii: 2619-16. [Epub ahead of print]
PMID: 27986927 [PubMed – as supplied by publisher]
Similar articles
4.Fibromyalgia interacts with age to change the brain.
Ceko M, Bushnell MC, Fitzcharles MA, Schweinhardt P.
Neuroimage Clin. 2013 Sep 6;3:249-60. doi: 10.1016/j.nicl.2013.08.015.
PMID: 24273710 [PubMed] Free PMC Article
Similar articles
5.Striatal grey matter increase in patients suffering from fibromyalgia–a voxel-based morphometry study.
Schmidt-Wilcke T, Luerding R, Weigand T, Jürgens T, Schuierer G, Leinisch E, Bogdahn U.
Pain. 2007 Nov;132 Suppl 1:S109-16.
PMID: 17587497 [PubMed – indexed for MEDLINE]
Similar articles
6.Pain is associated with regional grey matter reduction in the general population.
Ruscheweyh R, Deppe M, Lohmann H, Stehling C, Flöel A, Ringelstein EB, Knecht S.
Pain. 2011 Apr;152(4):904-11. doi: 10.1016/j.pain.2011.01.013.
PMID: 21296501 [PubMed – indexed for MEDLINE]
Similar articles
7.Relations Between Brain Alterations and Clinical Pain Measures in Chronic Musculoskeletal Pain: A Systematic Review.
Coppieters I, Meeus M, Kregel J, Caeyenberghs K, De Pauw R, Goubert D, Cagnie B.
J Pain. 2016 Sep;17(9):949-62. doi: 10.1016/j.jpain.2016.04.005. Review.
PMID: 27263992 [Unknown status]
Similar articles
8.The impact of fibromyalgia symptoms on brain morphometry.
Diaz-Piedra C, Guzman MA, Buela-Casal G, Catena A.
Brain Imaging Behav. 2016 Dec;10(4):1184-1197.
PMID: 26615599 [Unknown status]
Similar articles
9.Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks.
Kim H, Kim J, Loggia ML, Cahalan C, Garcia RG, Vangel MG, Wasan AD, Edwards RR, Napadow V.
Neuroimage Clin. 2015 Mar 4;7:667-77. doi: 10.1016/j.nicl.2015.02.022.
PMID: 25844321 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
10.Structural alterations in brainstem of fibromyalgia syndrome patients correlate with sensitivity to mechanical pressure.
Fallon N, Alghamdi J, Chiu Y, Sluming V, Nurmikko T, Stancak A.
Neuroimage Clin. 2013 Aug 9;3:163-70. doi: 10.1016/j.nicl.2013.07.011.
PMID: 24179860 [PubMed] Free PMC Article
Similar articles

Leave a Comment

Your email address will not be published. Required fields are marked *