Fibromyalgia and CFS: The Effect of Trauma on Genetics

Today we will be discussing exciting new research that is demonstrating links between early life stress and modulation of genetics for cortisol receptors in the brain.  This new research is opening up our understanding of how trauma can influence physiologic responses years later and therefore be associated with conditions of chronic pain and chronic fatigue.

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1.Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review.
Palma-Gudiel H, Córdova-Palomera A, Leza JC, Fañanás L.
Neurosci Biobehav Rev. 2015 Aug;55:520-35. doi: 10.1016/j.neubiorev.2015.05.016. Epub 2015 Jun 11. Review.
PMID: 26073068 [PubMed – indexed for MEDLINE] Free Article
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2.Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis.
Palma-Gudiel H, Córdova-Palomera A, Eixarch E, Deuschle M, Fañanás L.
Epigenetics. 2015;10(10):893-902. doi: 10.1080/15592294.2015.1088630. Review.
PMID: 26327302 [PubMed – indexed for MEDLINE] Free PMC Article
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3.Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review.
Turecki G, Meaney MJ.
Biol Psychiatry. 2016 Jan 15;79(2):87-96. doi: 10.1016/j.biopsych.2014.11.022. Epub 2014 Dec 13. Review.
PMID: 25687413 [PubMed – indexed for MEDLINE] Free PMC Article
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4.The role of hypocortisolism in chronic fatigue syndrome.
Nijhof SL, Rutten JM, Uiterwaal CS, Bleijenberg G, Kimpen JL, Putte EM.
Psychoneuroendocrinology. 2014 Apr;42:199-206. doi: 10.1016/j.psyneuen.2014.01.017. Epub 2014 Jan 30.
PMID: 24636516 [PubMed – indexed for MEDLINE]
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5.Childhood stressors in the development of fatigue syndromes: a review of the past 20 years of research.
Borsini A, Hepgul N, Mondelli V, Chalder T, Pariante CM.
Psychol Med. 2014 Jul;44(9):1809-23. doi: 10.1017/S0033291713002468. Epub 2013 Oct 7. Review.
PMID: 24093427 [PubMed – indexed for MEDLINE]
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6.Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome.
Hall DL, Lattie EG, Antoni MH, Fletcher MA, Czaja S, Perdomo D, Klimas NG.
Psychoneuroendocrinology. 2014 Nov;49:26-31. doi: 10.1016/j.psyneuen.2014.06.021. Epub 2014 Jul 6.
PMID: 25049069 [PubMed – indexed for MEDLINE] Free PMC Article
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7.Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder.
Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ.
Biol Psychiatry. 2015 Feb 15;77(4):356-64. doi: 10.1016/j.biopsych.2014.02.006. Epub 2014 Feb 17.
PMID: 24661442 [PubMed – indexed for MEDLINE]
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8.Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.
Vangeel E, Van Den Eede F, Hompes T, Izzi B, Del Favero J, Moorkens G, Lambrechts D, Freson K, Claes S.
Psychosom Med. 2015 Oct;77(8):853-62. doi: 10.1097/PSY.0000000000000224.
PMID: 26230484 [PubMed – indexed for MEDLINE]
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9.Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.
Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM.
Epigenetics. 2008 Mar-Apr;3(2):97-106.
PMID: 18536531 [PubMed – indexed for MEDLINE]
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10.Self-critical perfectionism predicts lower cortisol response to experimental stress in patients with chronic fatigue syndrome.
Kempke S, Luyten P, Mayes LC, Van Houdenhove B, Claes S.
Health Psychol. 2016 Mar;35(3):298-307. doi: 10.1037/hea0000299. Epub 2015 Dec 21.
PMID: 26690635 [PubMed – indexed for MEDLINE]
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11.Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress.
Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OF, Spengler D.
Epigenetics. 2015;10(3):247-57. doi: 10.1080/15592294.2015.1017199.
PMID: 25793778 [PubMed – indexed for MEDLINE] Free PMC Article
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12.Ontogeny of hypothalamic glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in mice.
Laryea G, Arnett M, Muglia LJ.
Stress. 2015;18(4):400-7. doi: 10.3109/10253890.2015.1046832. Epub 2015 Jun 11.
PMID: 26068518 [PubMed – indexed for MEDLINE]
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