Diagnosing Concussion and TBI With Blood Tests?

Today we will be discussing new literature looking for biomarkers to detect concussions and traumatic brain injuries. We will discuss some of the exciting new findings as well as the current weaknesses in this model.

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1.In vitro models as a platform to investigate traumatic brain injury.
Kumaria A.
Altern Lab Anim. 2017 Sep;45(4):201-211. Review.
PMID: 28994300 [PubMed – in process]
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2.Cognitive fatigue: an impaired cortical inhibitory replenishment.
Touzet C.
Brain Inj. 2017 Jul 27:1-7. doi: 10.1080/02699052.2017.1344300. [Epub ahead of print]
PMID: 28750174 [PubMed – as supplied by publisher]
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3.IMPACT Score for Traumatic Brain Injury: Validation of the Prognostic Tool in a Spanish Cohort.
Egea-Guerrero JJ, Rodríguez-Rodríguez A, Gordillo-Escobar E, Fernández-Delgado E, Martínez-Roldán Á, Roldán-Reina Á, Durán-Martínez P, de Vega-Ríos E, Freire-Aragón MD, Vilches-Arenas Á, Murillo-Cabezas F, Quintana-Díaz M.
J Head Trauma Rehabil. 2017 Feb 10. doi: 10.1097/HTR.0000000000000292. [Epub ahead of print]
PMID: 28195955 [PubMed – as supplied by publisher]
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4.Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice.
Gerson J, Castillo-Carranza DL, Sengupta U, Bodani R, Prough DS, DeWitt DS, Hawkins BE, Kayed R.
J Neurotrauma. 2016 Nov 15;33(22):2034-2043. Epub 2016 Apr 22.
PMID: 26729399 [PubMed – in process]
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5.A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury.
Schiff L, Hadker N, Weiser S, Rausch C.
Mol Diagn Ther. 2012 Apr 1;16(2):79-92. doi: 10.2165/11631580-000000000-00000. Review.
PMID: 22497529 [PubMed – indexed for MEDLINE]
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6.S100 B: A new concept in neurocritical care.
Rezaei O, Pakdaman H, Gharehgozli K, Simani L, Vahedian-Azimi A, Asaadi S, Sahraei Z, Hajiesmaeili M.
Iran J Neurol. 2017 Apr 4;16(2):83-89. Review.
PMID: 28761630 [PubMed] Free PMC Article
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7.White matter damage after traumatic brain injury: A role for damage associated molecular patterns.
Braun M, Vaibhav K, Saad NM, Fatima S, Vender JR, Baban B, Hoda MN, Dhandapani KM.
Biochim Biophys Acta. 2017 May 19. pii: S0925-4439(17)30157-6. doi: 10.1016/j.bbadis.2017.05.020. [Epub ahead of print] Review.
PMID: 28533056 [PubMed – as supplied by publisher]
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8.H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury.
Lagerstedt L, Egea-Guerrero JJ, Bustamante A, Montaner J, Rodríguez-Rodríguez A, El Rahal A, Turck N, Quintana M, García-Armengol R, Prica CM, Andereggen E, Rinaldi L, Sarrafzadeh A, Schaller K, Sanchez JC.
PLoS One. 2017 Apr 18;12(4):e0175572. doi: 10.1371/journal.pone.0175572. eCollection 2017.
PMID: 28419114 [PubMed – indexed for MEDLINE] Free PMC Article
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9.A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury.
Thelin EP, Nelson DW, Bellander BM.
Acta Neurochir (Wien). 2017 Feb;159(2):209-225. doi: 10.1007/s00701-016-3046-3. Epub 2016 Dec 12. Review.
PMID: 27957604 [PubMed – indexed for MEDLINE] Free PMC Article
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10.The addition of S100B to guidelines for management of mild head injury is potentially cost saving.
Calcagnile O, Anell A, Undén J.
BMC Neurol. 2016 Oct 20;16(1):200.
PMID: 27765016 [PubMed – indexed for MEDLINE] Free PMC Article
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11.Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury.
Halstrom A, MacDonald E, Neil C, Arendts G, Fatovich D, Fitzgerald M.
J Clin Neurosci. 2017 Jan;35:104-108. doi: 10.1016/j.jocn.2016.09.006. Epub 2016 Sep 30.
PMID: 27697434 [PubMed – indexed for MEDLINE]
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12.Kinetic modelling of serum S100b after traumatic brain injury.
Ercole A, Thelin EP, Holst A, Bellander BM, Nelson DW.
BMC Neurol. 2016 Jun 17;16:93. doi: 10.1186/s12883-016-0614-3.
PMID: 27315805 [PubMed – indexed for MEDLINE] Free PMC Article
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13.Early CSF and Serum S100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachnoid Hemorrhage.
Kellermann I, Kleindienst A, Hore N, Buchfelder M, Brandner S.
Clin Neurol Neurosurg. 2016 Jun;145:79-83. doi: 10.1016/j.clineuro.2016.04.005. Epub 2016 Apr 8.
PMID: 27101088 [PubMed – indexed for MEDLINE]
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14.Biomarkers in traumatic brain injury: a review.
Toman E, Harrisson S, Belli T.
J R Army Med Corps. 2016 Apr;162(2):103-8. doi: 10.1136/jramc-2015-000517. Epub 2015 Nov 2. Review.
PMID: 26527607 [PubMed – indexed for MEDLINE]
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15.Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury.
Welch RD, Ayaz SI, Lewis LM, Unden J, Chen JY, Mika VH, Saville B, Tyndall JA, Nash M, Buki A, Barzo P, Hack D, Tortella FC, Schmid K, Hayes RL, Vossough A, Sweriduk ST, Bazarian JJ.
J Neurotrauma. 2016 Jan 15;33(2):203-14. doi: 10.1089/neu.2015.4149. Epub 2015 Dec 18.
PMID: 26467555 [PubMed – indexed for MEDLINE] Free PMC Article
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16.A Role of Serum-Based Neuronal and Glial Markers as Potential Predictors for Distinguishing Severity and Related Outcomes in Traumatic Brain Injury.
Lee JY, Lee CY, Kim HR, Lee CH, Kim HW, Kim JH.
J Korean Neurosurg Soc. 2015 Aug;58(2):93-100. doi: 10.3340/jkns.2015.58.2.93. Epub 2015 Aug 28.
PMID: 26361523 [PubMed] Free PMC Article
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17.S100B inhibition reduces behavioral and pathologic changes in experimental traumatic brain injury.
Kabadi SV, Stoica BA, Zimmer DB, Afanador L, Duffy KB, Loane DJ, Faden AI.
J Cereb Blood Flow Metab. 2015 Dec;35(12):2010-20. doi: 10.1038/jcbfm.2015.165. Epub 2015 Jul 8.
PMID: 26154869 [PubMed – indexed for MEDLINE] Free PMC Article
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18.Comparative Assessment of the Prognostic Value of Biomarkers in Traumatic Brain Injury Reveals an Independent Role for Serum Levels of Neurofilament Light.
Al Nimer F, Thelin E, Nyström H, Dring AM, Svenningsson A, Piehl F, Nelson DW, Bellander BM.
PLoS One. 2015 Jul 2;10(7):e0132177. doi: 10.1371/journal.pone.0132177. eCollection 2015.
PMID: 26136237 [PubMed – indexed for MEDLINE] Free PMC Article
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19.Blood Biomarkers in Moderate-To-Severe Traumatic Brain Injury: Potential Utility of a Multi-Marker Approach in Characterizing Outcome.
Di Battista AP, Buonora JE, Rhind SG, Hutchison MG, Baker AJ, Rizoli SB, Diaz-Arrastia R, Mueller GP.
Front Neurol. 2015 May 26;6:110. doi: 10.3389/fneur.2015.00110. eCollection 2015.
PMID: 26074866 [PubMed] Free PMC Article
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20.S100B and Glial Fibrillary Acidic Protein as Indexes to Monitor Damage Severity in an In Vitro Model of Traumatic Brain Injury.
Di Pietro V, Amorini AM, Lazzarino G, Yakoub KM, D’Urso S, Lazzarino G, Belli A.
Neurochem Res. 2015 May;40(5):991-9. doi: 10.1007/s11064-015-1554-9. Epub 2015 Apr 22.
PMID: 25898931 [PubMed – indexed for MEDLINE]
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21.In Children and Youth with Mild and Moderate Traumatic Brain Injury, Glial Fibrillary Acidic Protein Out-Performs S100? in Detecting Traumatic Intracranial Lesions on Computed Tomography.
Papa L, Mittal MK, Ramirez J, Ramia M, Kirby S, Silvestri S, Giordano P, Weber K, Braga CF, Tan CN, Ameli NJ, Lopez M, Zonfrillo M.
J Neurotrauma. 2016 Jan 1;33(1):58-64. doi: 10.1089/neu.2015.3869. Epub 2015 Jun 3.
PMID: 25752485 [PubMed – indexed for MEDLINE] Free PMC Article
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22.Blood-brain barrier dysfunction following traumatic brain injury: correlation of K(trans) (DCE-MRI) and SUVR (99mTc-DTPA SPECT) but not serum S100B.
Winter C, Bell C, Whyte T, Cardinal J, Macfarlane D, Rose S.
Neurol Res. 2015 Jul;37(7):599-606. doi: 10.1179/1743132815Y.0000000018. Epub 2015 Mar 6.
PMID: 25749458 [PubMed – indexed for MEDLINE]
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23.Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.
Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M.
J Neurosci. 2015 Jan 14;35(2):518-26. doi: 10.1523/JNEUROSCI.3742-14.2015.
PMID: 25589747 [PubMed – indexed for MEDLINE] Free PMC Article
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24.Immunohistochemical investigation of S100 and NSE in cases of traumatic brain injury and its application for survival time determination.
Krohn M, Dreßler J, Bauer M, Schober K, Franke H, Ondruschka B.
J Neurotrauma. 2015 Apr 1;32(7):430-40. doi: 10.1089/neu.2014.3524. Epub 2015 Feb 4.
PMID: 25211554 [PubMed – indexed for MEDLINE]
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25.MLC901, a Traditional Chinese Medicine induces neuroprotective and neuroregenerative benefits after traumatic brain injury in rats.
Quintard H, Lorivel T, Gandin C, Lazdunski M, Heurteaux C.
Neuroscience. 2014 Sep 26;277:72-86. doi: 10.1016/j.neuroscience.2014.06.047. Epub 2014 Jun 30. Erratum in: Neuroscience. 2014 Oct 10;278:265-6.
PMID: 24993477 [PubMed – indexed for MEDLINE] Free Article
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