Diabetes, Obesity, and Alzheimer’s Look to the Gut

In today’s broadcast we will be discussing how these three conditions are impending tsunami’s if you will for our current health care system, and we will go into greater detail in this broadcast compared to others as to how new line therapies and research are targeting the gastrointestinal tract to improve these conditions.
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References:
1. Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects.
Radilla-Vázquez RB, Parra-Rojas I, Martínez-Hernández NE, Márquez-Sandoval YF, Illades-Aguiar B, Castro-Alarcón N.
Obes Facts. 2016;9(1):1-11. doi: 10.1159/000442479. Epub 2016 Jan 9.
PMID: 26745497 [PubMed – in process]
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2. Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior.
Lasselin J, Elsenbruch S, Lekander M, Axelsson J, Karshikoff B, Grigoleit JS, Engler H, Schedlowski M, Benson S.
Brain Behav Immun. 2016 Jan 11. pii: S0889-1591(16)30003-4. doi: 10.1016/j.bbi.2016.01.003. [Epub ahead of print]
PMID: 26790758 [PubMed – as supplied by publisher]
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3. Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation.
Palmer CD, Romero-Tejeda M, Sirignano M, Sharma S, Allen TM, Altfeld M, Jost S.
J Immunol. 2016 Jan 15;196(2):668-77. doi: 10.4049/jimmunol.1501888. Epub 2015 Dec 7.
PMID: 26643479 [PubMed – indexed for MEDLINE]
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4. Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice.
Lew WY, Bayna E, Molle ED, Dalton ND, Lai NC, Bhargava V, Mendiola V, Clopton P, Tang T.
PLoS One. 2013 Apr 9;8(4):e61057. doi: 10.1371/journal.pone.0061057. Print 2013.
PMID: 23585870 [PubMed – indexed for MEDLINE] Free PMC Article
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5. Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy.
Bajaj JS, Heuman DM, Sanyal AJ, Hylemon PB, Sterling RK, Stravitz RT, Fuchs M, Ridlon JM, Daita K, Monteith P, Noble NA, White MB, Fisher A, Sikaroodi M, Rangwala H, Gillevet PM.
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6. Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Zhou ZY, Ren LW, Zhan P, Yang HY, Chai DD, Yu ZW.
Acta Pharmacol Sin. 2016 Aug;37(8):1063-75. doi: 10.1038/aps.2016.21. Epub 2016 May 16.
PMID: 27180982 [PubMed – in process]
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7. Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation.
Guerville M, Boudry G.
Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G1-G15. doi: 10.1152/ajpgi.00098.2016. Epub 2016 May 5. Review.
PMID: 27151941 [PubMed – in process]
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8. Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity.
Jiang T, Gao X, Wu C, Tian F, Lei Q, Bi J, Xie B, Wang HY, Chen S, Wang X.
Nutrients. 2016 Feb 29;8(3):126. doi: 10.3390/nu8030126.
PMID: 26938554 [PubMed – in process] Free PMC Article
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9. Exogenous S-nitrosoglutathione attenuates inflammatory response and intestinal epithelial barrier injury in endotoxemic rats.
Li Z, Zhang X, Zhou H, Liu W, Li J.
J Trauma Acute Care Surg. 2016 Jun;80(6):977-84. doi: 10.1097/TA.0000000000001008.
PMID: 26891162 [PubMed – in process]
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10. Metabolic endotoxaemia in childhood obesity.
Varma MC, Kusminski CM, Azharian S, Gilardini L, Kumar S, Invitti C, McTernan PG.
BMC Obes. 2016 Jan 27;3:3. doi: 10.1186/s40608-016-0083-7. eCollection 2015.
PMID: 26819711 [PubMed] Free PMC Article
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11. LPS-Enhanced Glucose-Stimulated Insulin Secretion Is Normalized by Resveratrol.
Nøhr MK, Dudele A, Poulsen MM, Ebbesen LH, Radko Y, Christensen LP, Jessen N, Richelsen B, Lund S, Pedersen SB.
PLoS One. 2016 Jan 11;11(1):e0146840. doi: 10.1371/journal.pone.0146840. eCollection 2016.
PMID: 26751381 [PubMed – indexed for MEDLINE] Free PMC Article
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12. Duodenojejunal Bypass Leads to Altered Gut Microbiota and Strengthened Epithelial Barriers in Rats.
Yang PJ, Yang WS, Nien HC, Chen CN, Lee PH, Yu LC, Lin MT.
Obes Surg. 2016 Jul;26(7):1576-83. doi: 10.1007/s11695-015-1968-0.
PMID: 26615407 [PubMed – in process]
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13. Nonalcoholic fatty liver disease: Synopsis of current developments.
Onyekwere CA, Ogbera AO, Samaila AA, Balogun BO, Abdulkareem FB.
Niger J Clin Pract. 2015 Nov-Dec;18(6):703-12. doi: 10.4103/1119-3077.163288. Review.
PMID: 26289505 [PubMed – indexed for MEDLINE] Free Article
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14. Metabolic endotoxemia with obesity: Is it real and is it relevant?
Boutagy NE, McMillan RP, Frisard MI, Hulver MW.
Biochimie. 2016 May;124:11-20. doi: 10.1016/j.biochi.2015.06.020. Epub 2015 Jun 29. Review.
PMID: 26133659 [PubMed – in process]
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15. High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease.
Vaziri ND, Liu SM, Lau WL, Khazaeli M, Nazertehrani S, Farzaneh SH, Kieffer DA, Adams SH, Martin RJ.
PLoS One. 2014 Dec 9;9(12):e114881. doi: 10.1371/journal.pone.0114881. eCollection 2014.
PMID: 25490712 [PubMed – indexed for MEDLINE] Free PMC Article
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16. Immunization of cows with novel core glycolipid vaccine induces anti-endotoxin antibodies in bovine colostrum.
Cross AS, Karreman HJ, Zhang L, Rosenberg Z, Opal SM, Lees A.
Vaccine. 2014 Oct 21;32(46):6107-14. doi: 10.1016/j.vaccine.2014.08.083. Epub 2014 Sep 19.
PMID: 25242628 [PubMed – indexed for MEDLINE]
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17. Lactobacillus salivarius reverse diabetes-induced intestinal defense impairment in mice through non-defensin protein.
Chung PH, Wu YY, Chen PH, Fung CP, Hsu CM, Chen LW.
J Nutr Biochem. 2016 Jun 19;35:48-57. doi: 10.1016/j.jnutbio.2016.05.013. [Epub ahead of print]
PMID: 27376728 [PubMed – as supplied by publisher]
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18. Contribution of the distal small intestine to metabolic improvement after bariatric/metabolic surgery: Lessons from ileal transposition surgery.
Oh TJ, Ahn CH, Cho YM.
J Diabetes Investig. 2016 Apr;7 Suppl 1:94-101. doi: 10.1111/jdi.12444. Epub 2016 Mar 14. Review.
PMID: 27186363 [PubMed – in process] Free PMC Article
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19. Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice.
Li J, Lin S, Vanhoutte PM, Woo CW, Xu A.
Circulation. 2016 Jun 14;133(24):2434-46. doi: 10.1161/CIRCULATIONAHA.115.019645. Epub 2016 Apr 25.
PMID: 27143680 [PubMed – in process]
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20. [Alzheimer’s disease and diabetes – the common pathogenesis].
Halmos T, Suba I.
Neuropsychopharmacol Hung. 2016 Mar;18(1):5-19. Hungarian.
PMID: 27038867 [PubMed – in process] Free Article
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