Depression: Is Tryptophan Metabolism at the Core of the Issue?

In today’s broadcast we will be discussing how inflammation is gaining greater notoriety in the scientific literature as a primary cause of depression.  Yes, depression is multifactorial, but new research is demonstrating how inflammation leads to the abnormal breakdown of tryptophan leading to lower levels of serotonin.  However, the newest scientific research is demonstrating that rather than low serotonin levels, the “toxic” by products of tryptophan metabolism may be at the core of depression.
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21.Kynurenine pathway metabolites and suicidality.
Bryleva EY, Brundin L.
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22.Mast cells’ involvement in inflammation pathways linked to depression: evidence in mastocytosis.
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23.Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.
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24.Cognition and Emotions in Recurrent Depressive Disorders – The Role of Inflammation and the Kynurenine Pathway.
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25.Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.
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PMID: 26671617 [PubMed – as supplied by publisher]
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