Depression and Anxiety: Causes and Solutions

Today we have a passionate topic covering Anxiety and Depression.  We all know that the main line treatment for these conditions includes medications.  In today’s broadcast we will cover why these medications work, but we will go into greater detail exploring underlying causes of depression and anxiety that you may not be aware of and how this will translate into frontline therapies for these conditions.
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1.Homocysteine as a potential biomarker in bipolar disorders: a critical review and suggestions for improved studies.
Ghanizadeh A, Singh AB, Berk M, Torabi-Nami M.
Expert Opin Ther Targets. 2015 Jul;19(7):927-39. doi: 10.1517/14728222.2015.1019866. Epub 2015 Apr 16.
PMID: 25882812 [PubMed – in process]
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2.Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression.
Bhatia P, Singh N.
Fundam Clin Pharmacol. 2015 Aug 27. doi: 10.1111/fcp.12145. [Epub ahead of print] Review.
PMID: 26376956 [PubMed – as supplied by publisher]
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3.Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
Edney LC, Burns NR, Danthiir V.
Br J Nutr. 2015 Oct 28;114(8):1321-8. doi: 10.1017/S0007114515002949. Epub 2015 Sep 8.
PMID: 26346363 [PubMed – in process]
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4.Altered one-carbon metabolism in posttraumatic stress disorder.
de Vries GJ, Lok A, Mocking R, Assies J, Schene A, Olff M.
J Affect Disord. 2015 Sep 15;184:277-85. doi: 10.1016/j.jad.2015.05.062. Epub 2015 Jun 9.
PMID: 26120806 [PubMed – in process]
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5.The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
Lok A, Mocking RJ, Assies J, Koeter MW, Bockting CL, de Vries GJ, Visser I, Derks EM, Kayser M, Schene AH.
J Affect Disord. 2014 Sep;166:115-23. doi: 10.1016/j.jad.2014.04.048. Epub 2014 Apr 30.
PMID: 25012419 [PubMed – indexed for MEDLINE]
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6.Are genes connected with homocysteine metabolism associated with bipolar disorder?
Permoda-Osip A, Dmitrzak-Weglarz M, Hauser J, Rybakowski JK.
Neuropsychobiology. 2014;69(2):107-11. doi: 10.1159/000358091. Epub 2014 Feb 27.
PMID: 24577139 [PubMed – indexed for MEDLINE]
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7.Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
Delport D, Schoeman R, van der Merwe N, van der Merwe L, Fisher LR, Geiger D, Kotze MJ.
Metab Brain Dis. 2014 Jun;29(2):377-84. doi: 10.1007/s11011-014-9506-7. Epub 2014 Feb 18.
PMID: 24532086 [PubMed – indexed for MEDLINE]
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8.The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women.
Ró?ycka A, S?opie? R, S?opie? A, Dorszewska J, Seremak-Mrozikiewicz A, Lianeri M, Maciukiewicz M, Warenik-Szymankiewicz A, Grzelak T, Kurzawi?ska G, Drews K, Klejewski A, Jagodzi?ski PP.
Maturitas. 2015 Oct 30. pii: S0378-5122(15)30070-0. doi: 10.1016/j.maturitas.2015.10.011. [Epub ahead of print]
PMID: 26620113 [PubMed – as supplied by publisher]
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9.Epigenetics in Clinical Practice: Characterizing Patient and Provider Experiences with MTHFR Polymorphisms and Methylfolate.
Oberg E, Givant C, Fisk B, Parikh C, Bradley R.
J Nutrigenet Nutrigenomics. 2015;8(3):137-50. doi: 10.1159/000440700. Epub 2015 Oct 21.
PMID: 26484755 [PubMed – in process]
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Velichko VL, Kudlach OI, Shelepina OA.
Lik Sprava. 2015 Jan-Mar;(1-2):156-7. Russian.
PMID: 26118060 [PubMed – indexed for MEDLINE]
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11.B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline.
Mitchell ES, Conus N, Kaput J.
Neurosci Biobehav Rev. 2014 Nov;47:307-20. doi: 10.1016/j.neubiorev.2014.08.006. Epub 2014 Aug 27. Review.
PMID: 25173634 [PubMed – indexed for MEDLINE] Free Article
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12.Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population.
Shen X, Wu Y, Guan T, Wang X, Qian M, Lin M, Shen Z, Sun J, Zhong H, Yang J, Li L, Yuan Y.
J Affect Disord. 2014 Jun;161:73-8. doi: 10.1016/j.jad.2014.03.008. Epub 2014 Mar 14.
PMID: 24751310 [PubMed – indexed for MEDLINE]
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13.31-year-old female shows marked improvement in depression, agitation, and panic attacks after genetic testing was used to inform treatment.
Lawrence S.
Case Rep Psychiatry. 2014;2014:842349. doi: 10.1155/2014/842349. Epub 2014 Mar 18.
PMID: 24744941 [PubMed] Free PMC Article
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14.[Folates in the treatment of depression].
Erbe S, Pellert UN.
Fortschr Neurol Psychiatr. 2014 Feb;82(2):78-83. doi: 10.1055/s-0033-1356123. Epub 2014 Feb 11. Review. German.
PMID: 24519190 [PubMed – indexed for MEDLINE]
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15.Association analysis of the catechol-O-methyltransferase /methylenetetrahydrofolate reductase genes and cognition in late-onset depression.
Wang X, Wang Z, Wu Y, Yuan Y, Hou Z, Hou G.
Psychiatry Clin Neurosci. 2014 May;68(5):344-52. doi: 10.1111/pcn.12133. Epub 2013 Dec 25.
PMID: 24373005 [PubMed – indexed for MEDLINE]
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16.Folate: metabolism, genes, polymorphisms and the associated diseases.
Nazki FH, Sameer AS, Ganaie BA.
Gene. 2014 Jan 1;533(1):11-20. doi: 10.1016/j.gene.2013.09.063. Epub 2013 Oct 1. Review.
PMID: 24091066 [PubMed – indexed for MEDLINE]
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17.One-carbon metabolism and bipolar disorder.
Baek JH, Bernstein EE, Nierenberg AA.
Aust N Z J Psychiatry. 2013 Nov;47(11):1013-8. doi: 10.1177/0004867413502091. Epub 2013 Aug 22. Review.
PMID: 23969624 [PubMed – indexed for MEDLINE]
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18.Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.
Lok A, Bockting CL, Koeter MW, Snieder H, Assies J, Mocking RJ, Vinkers CH, Kahn RS, Boks MP, Schene AH.
Transl Psychiatry. 2013 Jul 30;3:e288. doi: 10.1038/tp.2013.60.
PMID: 23900311 [PubMed – indexed for MEDLINE] Free PMC Article
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19.Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies.
Wu YL, Ding XX, Sun YH, Yang HY, Chen J, Zhao X, Jiang YH, Lv XL, Wu ZQ.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:78-85. doi: 10.1016/j.pnpbp.2013.06.015. Epub 2013 Jul 4.
PMID: 23831680 [PubMed – indexed for MEDLINE]
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20.Beyond the resistance: how novel neurobiological understandings of depression may lead to advanced treatment strategies.
Jain R, Jackson WC.
J Clin Psychiatry. 2012 Nov;73(11):e30. doi: 10.4088/JCP.12020wc3.
PMID: 23218168 [PubMed – indexed for MEDLINE]
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