Chronic Pain – Why is this epidemic getting worse?

Last week we discussed that there is no silver bullet for chronic pain. Today we are going a little deeper into the discussion and we are going to highlight the societal aspects of chronic pain, and how our daily habits and routines are overwhelming the health care system’s ability to treat one condition with one “magic pill,” as so many in our society have multiple problems and vicious cycles deteriorating their health.
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2.Neural Plasticity in Obesity and Psychiatric Disorders.
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Neural Plast. 2016;2016:6053871. doi: 10.1155/2016/6053871. Epub 2016 Apr 7. No abstract available.
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3.A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study.
Raider K, Ma D, Harris JL, Fuentes I, Rogers RS, Wheatley JL, Geiger PC, Yeh HW, Choi IY, Brooks WM, Stanford JA.
Neurochem Int. 2016 Apr 26. pii: S0197-0186(16)30058-4. doi: 10.1016/j.neuint.2016.04.008. [Epub ahead of print]
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4.Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress.
Ali MR, Abo-Youssef AM, Messiha BA, Khattab MM.
Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar 30. [Epub ahead of print]
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5.LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals.
Catorce MN, Gevorkian G.
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6.Loss of tau rescues inflammation-mediated neurodegeneration.
Maphis N, Xu G, Kokiko-Cochran ON, Cardona AE, Ransohoff RM, Lamb BT, Bhaskar K.
Front Neurosci. 2015 Jun 3;9:196. doi: 10.3389/fnins.2015.00196. eCollection 2015.
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7.Associations between Diet Behaviors and Measures of Glycemia, in Clinical Setting, in Obese Adolescents.
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Child Obes. 2016 May 2. [Epub ahead of print]
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8.Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study.
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9.Predictors of Improvements in Pain Intensity in a National Cohort of Older Veterans with Chronic Pain.
Dobscha SK, Lovejoy TI, Morasco BJ, Kovas AE, Peters DM, Hart K, Williams JL, McFarland BH.
J Pain. 2016 Apr 4. pii: S1526-5900(16)30003-7. doi: 10.1016/j.jpain.2016.03.006. [Epub ahead of print]
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10.Does perceived injustice correlate with pain intensity and disability in orthopaedic trauma patients?
van Leeuwen WF, van der Vliet QM, Janssen SJ, Heng M, Ring D, Vranceanu AM.
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11.Epidemiology of chronic low back pain in US adults: National Health and Nutrition Examination Survey 2009-2010.
Shmagel A, Foley R, Ibrahim H.
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12.CDC Guideline for Prescribing Opioids for Chronic Pain–United States, 2016.
Dowell D, Haegerich TM, Chou R.
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13.Modality and sex differences in pain sensitivity during human endotoxemia.
Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M, Kosek E, Olgart Höglund C, Axelsson J.
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14.Inflammation-induced hyperalgesia: effects of timing, dosage, and negative affect on somatic pain sensitivity in human experimental endotoxemia.
Wegner A, Elsenbruch S, Maluck J, Grigoleit JS, Engler H, Jäger M, Spreitzer I, Schedlowski M, Benson S.
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15.Chronic functional bowel syndrome enhances gut-brain axis dysfunction, neuroinflammation, cognitive impairment, and vulnerability to dementia.
Daulatzai MA.
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16.[Alzheimer’s disease and diabetes – the common pathogenesis].
Halmos T, Suba I.
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17.Composition, Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes.
Lambeth SM, Carson T, Lowe J, Ramaraj T, Leff JW, Luo L, Bell CJ, Shah VO.
J Diabetes Obes. 2015 Dec 26;2(3):1-7.
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