Chronic Lyme Disease: More Acceptance that it’s Autoimmune

Today we will be talking about Chronic Lyme Disease (also referred to as Post Lyme Disease Syndrome and Post Lyme Disease Treatment Syndrome). Upwards of 10% of individuals infected by the Lyme spirochete have persistent symptoms though many have been through courses of antibiotics. Though autoimmunity was hypothesized as a cause of persistent Lyme Disease symptoms following Borrelia infection, now it has been confirmed to be present in those suffering with persistent symptoms of Lyme Disease. Today we will go over new data and older research articles examining the relationships between the infectious trigger and the resultant autoimmune responses that ensue.
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References:
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?cieszka J, D?bek J, Cie?lik P.
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PMID: 27407225 [PubMed] Free PMC Article
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2. Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome.
Chandra A, Wormser GP, Marques AR, Latov N, Alaedini A.
Clin Vaccine Immunol. 2011 May;18(5):767-71. doi: 10.1128/CVI.00002-11. Epub 2011 Mar 16.
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3. Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms.
Chandra A, Wormser GP, Klempner MS, Trevino RP, Crow MK, Latov N, Alaedini A.
Brain Behav Immun. 2010 Aug;24(6):1018-24. doi: 10.1016/j.bbi.2010.03.002. Epub 2010 Mar 18.
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4. Increased IFN? activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits.
Jacek E, Fallon BA, Chandra A, Crow MK, Wormser GP, Alaedini A.
J Neuroimmunol. 2013 Feb 15;255(1-2):85-91. doi: 10.1016/j.jneuroim.2012.10.011. Epub 2012 Nov 8.
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5. [Post-Lyme disease syndrome].
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Pol Merkur Lekarski. 2016 Feb;40(236):129-33. Review. Polish.
PMID: 27000820 [PubMed – indexed for MEDLINE]
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6. Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthropathy, Following Lyme Disease.
Arvikar SL, Crowley JT, Sulka KB, Steere AC.
Arthritis Rheumatol. 2016 Sep 16. doi: 10.1002/art.39866. [Epub ahead of print]
PMID: 27636905 [PubMed – as supplied by publisher]
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7. Lyme disease and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): an overview.
Rhee H, Cameron DJ.
Int J Gen Med. 2012;5:163-74. doi: 10.2147/IJGM.S24212. Epub 2012 Feb 22.
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8. Epitope-Specific Evolution of Human B Cell Responses to Borrelia burgdorferi VlsE Protein from Early to Late Stages of Lyme Disease.
Jacek E, Tang KS, Komorowski L, Ajamian M, Probst C, Stevenson B, Wormser GP, Marques AR, Alaedini A.
J Immunol. 2016 Feb 1;196(3):1036-43. doi: 10.4049/jimmunol.1501861. Epub 2015 Dec 30.
PMID: 26718339 [PubMed – indexed for MEDLINE] Free PMC Article
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9. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.
Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC.
J Autoimmun. 2016 May;69:24-37. doi: 10.1016/j.jaut.2016.02.005. Epub 2016 Feb 26.
PMID: 26922382 [PubMed – in process]
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10. Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis.
Pianta A, Drouin EE, Crowley JT, Arvikar S, Strle K, Costello CE, Steere AC.
Clin Immunol. 2015 Oct;160(2):336-41. doi: 10.1016/j.clim.2015.07.005. Epub 2015 Jul 15.
PMID: 26187145 [PubMed – indexed for MEDLINE] Free PMC Article
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11. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease.
Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londoño D, Yao C, Costello CE, Steere AC.
Arthritis Rheum. 2013 Jan;65(1):186-96. doi: 10.1002/art.37732.
PMID: 23044924 [PubMed – indexed for MEDLINE] Free PMC Article
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12. Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis.
Steere AC, Gross D, Meyer AL, Huber BT.
J Autoimmun. 2001 May;16(3):263-8. Review.
PMID: 11334491 [PubMed – indexed for MEDLINE]
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