Alzheimer’s Disease and Memory Problems, are Sugar, Excessive Carbohydrates, and Fat the Problem?

This morning we are discussing the growing problem of Alzheimer’s disease as well as memory problems.  The pharmaceutical community has tenaciously been pursuing solutions to these issues, yet unfortunately the results to date have not been satisfactory to many clinicians and patients.  Today we discuss the new relationships tying obesity and type II diabetes to Alzheimer’s disease, and the lifestyle interventions that could be employed to combat these changes.
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1.In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease.
Oskarsson ME, Paulsson JF, Schultz SW, Ingelsson M, Westermark P, Westermark GT.
Am J Pathol. 2015 Mar;185(3):834-46. doi: 10.1016/j.ajpath.2014.11.016. Epub 2015 Feb 17.
PMID: 25700985 [PubMed – in process]
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2.Small Molecules And Alzheimer’s Disease: Misfolding, Metabolism And Imaging.
Patel V, Zhang X, Tautiva NA, Nyabera AN, Owa OO, Baidya M, Sung HC, Taunk PS, Abdollahi S, Charles S, Gonella RA, Gadi N, Duong KT, Fawver JN, Ran C, Jalonen TO, Murray IV.
Curr Alzheimer Res. 2015 May 4. [Epub ahead of print]
PMID: 25938871 [PubMed – as supplied by publisher]
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3.Anorexigenic lipopeptides ameliorate central insulin signaling and attenuate tau phosphorylation in hippocampi of mice with monosodium glutamate-induced obesity.
Špolcová A, Mikulášková B, Holubová M, Nagelová V, Pirnik Z, Zemenová J, Haluzík M, Železná B, Galas MC, Maletínská L.
J Alzheimers Dis. 2015 Jan 1;45(3):823-35. doi: 10.3233/JAD-143150.
PMID: 25624414 [PubMed – in process]
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4.Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS.
Neurobiol Aging. 2015 Mar;36(3):1600.e1-4. doi: 10.1016/j.neurobiolaging.2014.12.023. Epub 2014 Dec 24.
PMID: 25585531 [PubMed – in process]
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5.Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-? oligomer-treated hippocampal neurons.
Takach O, Gill TB, Silverman MA.
Neurobiol Aging. 2015 Mar;36(3):1378-82. doi: 10.1016/j.neurobiolaging.2014.11.018. Epub 2014 Dec 3.
PMID: 25543463 [PubMed – in process]
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6.High-Fat Diet-Induced Deregulation Of Hippocampal Insulin Signaling And Mitochondrial Homeostasis Deficiences Contribute To Alzheimer Disease Pathology In Rodents.
Petrov D, Pedrós I, Artiach G, Sureda FX, Barroso E, Pallàs M, Casadesús G, Beas-Zarate C, Carro E, Ferrer I, Vazquez-Carrera M, Folch J, Camins A.
Biochim Biophys Acta. 2015 May 20. pii: S0925-4439(15)00147-7. doi: 10.1016/j.bbadis.2015.05.004. [Epub ahead of print]
PMID: 26003667 [PubMed – as supplied by publisher]
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7.The role of dietary coconut for the prevention and treatment of Alzheimer’s disease: potential mechanisms of action.
Fernando WM, Martins IJ, Goozee KG, Brennan CS, Jayasena V, Martins RN.
Br J Nutr. 2015 May 22:1-14. [Epub ahead of print]
PMID: 25997382 [PubMed – as supplied by publisher]
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8.Biomarkers of Alzheimer Disease, Insulin Resistance, and Obesity in Childhood.
Luciano R, Barraco GM, Muraca M, Ottino S, Spreghini MR, Sforza RW, Rustico C, Morino GS, Manco M.
Pediatrics. 2015 May 11. pii: peds.2014-2391. [Epub ahead of print]
PMID: 25963004 [PubMed – as supplied by publisher]
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9.Prevention of Alzheimer disease: The roles of nutrition and primary care.
Bane TJ, Cole C.
Nurse Pract. 2015 May 15;40(5):30-5. doi: 10.1097/01.NPR.0000463782.57968.c2.
PMID: 25839697 [PubMed – in process]
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10.Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.
Cunningham C, Hennessy E.
Alzheimers Res Ther. 2015 Mar 24;7(1):33. doi: 10.1186/s13195-015-0117-2. eCollection 2015.
PMID: 25802557 [PubMed] Free PMC Article
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