Adrenal Fatigue, the Facts Explained

Today we are discussing Adrenal Fatigue.  Many of us realize that when we are under stress for long periods that this may be associated with feeling tired and run down. However, Adrenal Fatigue is not a recognized medical diagnosis. Today we will present the research on this and explain why this prevalent problem should be more readily accepted and treated.
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1.Physical activity and environmental influences on adrenal fatigue of Saudi adults: biochemical analysis and questionnaire survey.
Alghadir AH, Gabr SA.
J Phys Ther Sci. 2015 Jul;27(7):2045-51. doi: 10.1589/jpts.27.2045. Epub 2015 Jul 22.
PMID: 26311923 [PubMed] Free PMC Article
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2.Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With Hypothalamic-Pituitary-Adrenal Axis Hypofunction and Childhood Trauma.
Vangeel E, Van Den Eede F, Hompes T, Izzi B, Del Favero J, Moorkens G, Lambrechts D, Freson K, Claes S.
Psychosom Med. 2015 Jul 30. [Epub ahead of print]
PMID: 26230484 [PubMed – as supplied by publisher]
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3.Achieving Remission in Gulf War Illness: A Simulation-Based Approach to Treatment Design.
Craddock TJ, Del Rosario RR, Rice M, Zysman JP, Fletcher MA, Klimas NG, Broderick G.
PLoS One. 2015 Jul 20;10(7):e0132774. doi: 10.1371/journal.pone.0132774. eCollection 2015.
PMID: 26192591 [PubMed – in process] Free PMC Article
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4.Toxic stress, inflammation and symptomatology of chronic complications in diabetes.
Downs CA, Faulkner MS.
World J Diabetes. 2015 May 15;6(4):554-65. doi: 10.4239/wjd.v6.i4.554. Review.
PMID: 25987953 [PubMed] Free PMC Article
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5.Adrenal gland hormones in primary school children.
Shaikhelismanova MV, Dikopol’skaya NB, Sitdikov FG, Bilalova GA.
Bull Exp Biol Med. 2015 Apr;158(6):715-7. doi: 10.1007/s10517-015-2844-6. Epub 2015 Apr 21.
PMID: 25894769 [PubMed – in process]
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6.Fibromyalgia and chronic fatigue: the underlying biology and related theoretical issues.
Romano GF, Tomassi S, Russell A, Mondelli V, Pariante CM.
Adv Psychosom Med. 2015;34:61-77. doi: 10.1159/000369085. Epub 2015 Mar 30. Review.
PMID: 25832514 [PubMed – indexed for MEDLINE]
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7.Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.
Kempke S, Luyten P, De Coninck S, Van Houdenhove B, Mayes LC, Claes S.
Psychoneuroendocrinology. 2015 Feb;52:14-21. doi: 10.1016/j.psyneuen.2014.10.027. Epub 2014 Nov 8.
PMID: 25459889 [PubMed – in process]
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8.The gut microbiome and the brain.
Galland L.
J Med Food. 2014 Dec;17(12):1261-72. doi: 10.1089/jmf.2014.7000. Review.
PMID: 25402818 [PubMed – indexed for MEDLINE]
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9.Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome.
Hall DL, Lattie EG, Antoni MH, Fletcher MA, Czaja S, Perdomo D, Klimas NG.
Psychoneuroendocrinology. 2014 Nov;49:26-31. doi: 10.1016/j.psyneuen.2014.06.021. Epub 2014 Jul 6.
PMID: 25049069 [PubMed – indexed for MEDLINE]
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10.The role of hypocortisolism in chronic fatigue syndrome.
Nijhof SL, Rutten JM, Uiterwaal CS, Bleijenberg G, Kimpen JL, Putte EM.
Psychoneuroendocrinology. 2014 Apr;42:199-206. doi: 10.1016/j.psyneuen.2014.01.017. Epub 2014 Jan 30.
PMID: 24636516 [PubMed – indexed for MEDLINE]
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11.Unstimulated cortisol secretory activity in everyday life and its relationship with fatigue and chronic fatigue syndrome: a systematic review and subset meta-analysis.
Powell DJ, Liossi C, Moss-Morris R, Schlotz W.
Psychoneuroendocrinology. 2013 Nov;38(11):2405-22. doi: 10.1016/j.psyneuen.2013.07.004. Epub 2013 Aug 2. Review.
PMID: 23916911 [PubMed – indexed for MEDLINE] Free Article
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12.Cortisol Profile Mediates the Relation Between Childhood Neglect and Pain and Emotional Symptoms among Patients with Fibromyalgia.
Yeung EW, Davis MC, Ciaramitaro MC.
Ann Behav Med. 2015 Sep 24. [Epub ahead of print]
PMID: 26404060 [PubMed – as supplied by publisher]
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13.Mindfulness meditation alleviates fibromyalgia symptoms in women: results of a randomized clinical trial.
Cash E, Salmon P, Weissbecker I, Rebholz WN, Bayley-Veloso R, Zimmaro LA, Floyd A, Dedert E, Sephton SE.
Ann Behav Med. 2015 Jun;49(3):319-30. doi: 10.1007/s12160-014-9665-0.
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14.Circadian rhythm of serum cortisol in female patients with fibromyalgia syndrome.
Fatima G, Das SK, Mahdi AA, Verma NS, Khan FH, Tiwari AM, Jafer T, Anjum B.
Indian J Clin Biochem. 2013 Apr;28(2):181-4. doi: 10.1007/s12291-012-0258-z. Epub 2012 Sep 27.
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15.The Cortisol Paradox of Trauma-Related Disorders: Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood.
Schalinski I, Elbert T, Steudte-Schmiedgen S, Kirschbaum C.
PLoS One. 2015 Aug 28;10(8):e0136921. doi: 10.1371/journal.pone.0136921. eCollection 2015.
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16.Pilot Study on Childhood Sexual Abuse, Diurnal Cortisol Secretion, and Weight Loss in Bariatric Surgery Patients.
Hulme PA, McBride CL, Kupzyk KA, French JA.
J Child Sex Abus. 2015;24(4):385-400. doi: 10.1080/10538712.2015.1022293.
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17.Differential associations between childhood trauma subtypes and adolescent HPA-axis functioning.
Kuhlman KR, Geiss EG, Vargas I, Lopez-Duran NL.
Psychoneuroendocrinology. 2015 Apr;54:103-14. doi: 10.1016/j.psyneuen.2015.01.020. Epub 2015 Feb 2.
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