PHT Live – Polycystic Ovarian Syndrome (PCOS) and Andropause as They Relate to the Gut

To Watch Live Hangout hit the play button
Have questions?  Ask below!

This week we are doing our Google Hangout/Broadcast on Polycystic Ovarian Syndrome (PCOS) and Andropause as they relate to the gut.

We will discuss the underlying mechanisms of PCOS including androgen dominance, obesity, and insulin resistance. Also, we will discuss Andropause as it relates to males having lower testosterone and elevated estrogen levels, and why taking testosterone is not always the best fit for male patients.

Then we will tie in the gastrointestinal tracts relationship to one of the key mechanisms for both of these disorders, obesity. Tune in if you or a loved one suffers with PCOS or Andropause, and feel free to direct your questions to us so that we can answer them live!

 

1. Epidemiology, diagnosis, and management of polycystic ovary syndrome.
Sirmans SM, Pate KA.
Clin Epidemiol. 2013 Dec 18;6:1-13. eCollection 2013. Review.
PMID: 24379699 [PubMed – as supplied by publisher] Free PMC Article
Related citations
2. Dyslipidemia in women with polycystic ovary syndrome.
Kim JJ, Choi YM.
Obstet Gynecol Sci. 2013 May;56(3):137-142. Epub 2013 May 16. Review.
PMID: 24327994 [PubMed – as supplied by publisher] Free PMC Article
Related citations
3. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review.
Krul-Poel YH, Snackey C, Louwers Y, Lips P, Lambalk CB, Laven JS, Simsek S.
Eur J Endocrinol. 2013 Oct 23;169(6):853-65. doi: 10.1530/EJE-13-0617. Print 2013 Dec. Review.
PMID: 24044903 [PubMed – indexed for MEDLINE] Free Article
Related citations
4. Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome.
Carmina E.
Front Horm Res. 2013;40:40-50. doi: 10.1159/000341840. Epub 2012 Oct 18. Review.
PMID: 24002404 [PubMed – indexed for MEDLINE]
Related citations
5. Insulin sensitizers in polycystic ovary syndrome.
Pasquali R, Gambineri A.
Front Horm Res. 2013;40:83-102. doi: 10.1159/000341837. Epub 2012 Oct 18. Review.
PMID: 24002407 [PubMed – indexed for MEDLINE]
Related citations
6. Genetics in endocrinology: genetic forms of severe insulin resistance: what endocrinologists should know.
Parker VE, Semple RK.
Eur J Endocrinol. 2013 Sep 12;169(4):R71-80. doi: 10.1530/EJE-13-0327. Print 2013 Oct. Review.
PMID: 23857978 [PubMed – indexed for MEDLINE] Free Article
Related citations
7. Metabolic complications of obesity.
Pedersen SD.
Best Pract Res Clin Endocrinol Metab. 2013 Apr;27(2):179-93. doi: 10.1016/j.beem.2013.02.004. Epub 2013 Mar 6. Review.
PMID: 23731880 [PubMed – indexed for MEDLINE]
Related citations
8. Interventions for the metabolic dysfunction in polycystic ovary syndrome.
Bozdag G, Yildiz BO.
Steroids. 2013 Aug;78(8):777-81. doi: 10.1016/j.steroids.2013.04.008. Epub 2013 Apr 24. Review.
PMID: 23624033 [PubMed – indexed for MEDLINE]
Related citations
9. [Diabetes and prediabetes in endocrine disorders].
Krysiak R, Rudzki H, Okopie? B.
Wiad Lek. 2012;65(3):187-98. Review. Polish.
PMID: 23289266 [PubMed – indexed for MEDLINE]
Related citations
10. The role of cytokines in polycystic ovarian syndrome.
Ebejer K, Calleja-Agius J.
Gynecol Endocrinol. 2013 Jun;29(6):536-40. doi: 10.3109/09513590.2012.760195. Epub 2013 Feb 1. Review.
PMID: 23368758 [PubMed – indexed for MEDLINE]
Related citations
11. Polycystic ovarian syndrome management options.
Bates GW Jr, Propst AM.
Obstet Gynecol Clin North Am. 2012 Dec;39(4):495-506. doi: 10.1016/j.ogc.2012.10.001. Review.
PMID: 23182556 [PubMed – indexed for MEDLINE]
Related citations
12. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines.
Moran LJ, Ko H, Misso M, Marsh K, Noakes M, Talbot M, Frearson M, Thondan M, Stepto N, Teede HJ.
J Acad Nutr Diet. 2013 Apr;113(4):520-45. doi: 10.1016/j.jand.2012.11.018. Epub 2013 Feb 16. Review.
PMID: 23420000 [PubMed – indexed for MEDLINE]
Related citations
13. Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS.
Sinawat S, Buppasiri P, Lumbiganon P, Pattanittum P.
Cochrane Database Syst Rev. 2012 Oct 17;10:CD006226. doi: 10.1002/14651858.CD006226.pub3. Review.
PMID: 23076922 [PubMed – indexed for MEDLINE]
Related citations
14. Obesity and PCOS: implications for diagnosis and treatment.
Legro RS.
Semin Reprod Med. 2012 Dec;30(6):496-506. doi: 10.1055/s-0032-1328878. Epub 2012 Oct 16. Review.
PMID: 23074008 [PubMed – indexed for MEDLINE] Free PMC Article
Related citations
15. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.
Diamanti-Kandarakis E, Dunaif A.
Endocr Rev. 2012 Dec;33(6):981-1030. doi: 10.1210/er.2011-1034. Epub 2012 Oct 12. Review.
PMID: 23065822 [PubMed – indexed for MEDLINE]
Related citations
16. Adiponectin and the control of female reproductive functions.
Palin MF, Bordignon VV, Murphy BD.
Vitam Horm. 2012;90:239-87. doi: 10.1016/B978-0-12-398313-8.00010-5. Review.
PMID: 23017719 [PubMed – indexed for MEDLINE]
Related citations
17. Long-term reproductive and metabolic consequences of PCOS.
Hudecova M, Jan H, Christian B, Poromaa Inger S.
Curr Diabetes Rev. 2012 Nov;8(6):444-51. Review.
PMID: 22934549 [PubMed – indexed for MEDLINE]
Related citations
18. Effects of thiazolidinediones on polycystic ovary syndrome: a meta-analysis of randomized placebo-controlled trials.
Du Q, Yang S, Wang YJ, Wu B, Zhao YY, Fan B.
Adv Ther. 2012 Sep;29(9):763-74. doi: 10.1007/s12325-012-0044-6. Epub 2012 Aug 28. Review.
PMID: 22932791 [PubMed – indexed for MEDLINE]
Related citations
19. The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?
Lansdown A, Rees DA.
Clin Endocrinol (Oxf). 2012 Dec;77(6):791-801. doi: 10.1111/cen.12003. Review.
PMID: 22882204 [PubMed – indexed for MEDLINE]
Related citations
20. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH.
Cochrane Database Syst Rev. 2012 May 16;5:CD003053. doi: 10.1002/14651858.CD003053.pub5. Review.
PMID: 22592687 [PubMed – indexed for MEDLINE]
Related citations
21. The role of obesity in the development of polycystic ovary syndrome.
Motta AB.
Curr Pharm Des. 2012;18(17):2482-91. Review.
PMID: 22376149 [PubMed – indexed for MEDLINE]
Related citations
22. 17?-Hydroxylase (CYP17) expression and subsequent androstenedione production in the human ovary.
Patel SS, Beshay VE, Escobar JC, Carr BR.
Reprod Sci. 2010 Nov;17(11):978-86. doi: 10.1177/1933719110379055. Epub 2010 Aug 18. Review.
PMID: 20720262 [PubMed – indexed for MEDLINE]
Related citations
23. Insulin and hyperandrogenism in women with polycystic ovary syndrome.
Baptiste CG, Battista MC, Trottier A, Baillargeon JP.
J Steroid Biochem Mol Biol. 2010 Oct;122(1-3):42-52. doi: 10.1016/j.jsbmb.2009.12.010. Epub 2009 Dec 28. Review.
PMID: 20036327 [PubMed – indexed for MEDLINE] Free PMC Article
Related citations
24. Disorders of androgen synthesis–from cholesterol to dehydroepiandrosterone.
Miller WL.
Med Princ Pract. 2005;14 Suppl 1:58-68. Review.
PMID: 16103714 [PubMed – indexed for MEDLINE]
Related citations
25. Adrenal disorders and polycystic ovary syndrome.
Dunaif A.
Horm Res. 1992;37 Suppl 3:39-44. Review.
PMID: 1427640 [PubMed – indexed for MEDLINE]
Related citations
26. Mouse models to study polycystic ovary syndrome: A possible link between metabolism and ovarian function?
van Houten EL, Visser JA.
Reprod Biol. 2014 Mar;14(1):32-43. doi: 10.1016/j.repbio.2013.09.007. Epub 2013 Oct 11. Review.
PMID: 24607253 [PubMed – as supplied by publisher]
Related citations
27. Therapy in endocrine disease: treatment of hirsutism in the polycystic ovary syndrome.
Pasquali R, Gambineri A.
Eur J Endocrinol. 2013 Dec 21;170(2):R75-90. doi: 10.1530/EJE-13-0585. Print 2014 Feb. Review.
PMID: 24272197 [PubMed – indexed for MEDLINE] Free Article
Related citations
28. Female Pattern Hair Loss.
Herskovitz I, Tosti A.
Int J Endocrinol Metab. 2013 Oct 21;11(4):e9860. eCollection 2013 Oct. Review.
PMID: 24719635 [PubMed – as supplied by publisher] Free PMC Article
Related citations
29. Pathophysiology of polycystic ovary syndrome: the role of hyperandrogenism.
Catteau-Jonard S, Dewailly D.
Front Horm Res. 2013;40:22-7. doi: 10.1159/000341679. Epub 2012 Oct 18. Review.
PMID: 24002402 [PubMed – indexed for MEDLINE]
Related citations
30. [Androgen deficit and diabetes].
Cáp J.
Vnitr Lek. 2012 Mar;58(3):228-31. Review. Czech.
PMID: 22486290 [PubMed – indexed for MEDLINE]
Related citations
31. Obesity and gonadal function of women.
Diamanti-Kandarakis E, Kandarakis HA.
Pediatr Endocrinol Rev. 2004 Aug;1 Suppl 3:465-70. Review.
PMID: 16444176 [PubMed – indexed for MEDLINE]
Related citations
32. [Adipose tissue: a real endocrine gland synthesizing hormones and cytokines: clinical implications].
Martin-Du Pan RC, Giusti V.
Rev Med Suisse Romande. 2004 Mar;124(3):171-5. Review. French.
PMID: 15095664 [PubMed – indexed for MEDLINE]
Related citations
33. Estradiol in elderly men.
Vermeulen A, Kaufman JM, Goemaere S, van Pottelberg I.
Aging Male. 2002 Jun;5(2):98-102. Review.
PMID: 12198740 [PubMed – indexed for MEDLINE]
Related citations
34. Impact of obesity on hypogonadism in the andropause.
Tan RS, Pu SJ.
Int J Androl. 2002 Aug;25(4):195-201. Review.
PMID: 12121568 [PubMed – indexed for MEDLINE]
Related citations
35. The influence of obesity on hyperandrogenism and infertility in the female.
Diamanti-Kandarakis E, Bergiele A.
Obes Rev. 2001 Nov;2(4):231-8. Review.
PMID: 12119994 [PubMed – indexed for MEDLINE]
Related citations

One Comment

  1. Thank you so much for this indepth video about pcos. I suffer from this HORRIBLE condition. I just recently started to research this to find any way to help me. Like you said, I am one of those that could not lose weight eating 1000cals a day doing an hour high intensity work-outs. I have been feeling so hopeless. I went to the Dr. Last week and had some blood tests done and an ultrasound yesterday. He put me on a low carb diet. I know I am a severe case. This thing about the GUT being the center of it all.. I believe 100%. I have every symptom in a severe way. I would love to know if there is a diet “lifestyle change”, you recommend? I need all the help I could get. Again.. Thank you soooo much for this video!

Leave a Comment

Your email address will not be published. Required fields are marked *

*

This site uses Akismet to reduce spam. Learn how your comment data is processed.