Restless Leg Syndrome Answers for a Better Nights Sleep

Today we are discussing restless leg syndrome. We have done several broadcasts on restless leg syndrome, however today we are going to tie the separate pieces together so that you as the restless leg suffer, or loved one of a restless leg suffer, has a better idea as to the causes of the condition as well as the natural management strategies that are available.
Please enjoy, and send us your questions.  Please forward us any questions here on our website or go to our Power Health Facebook page
1.Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease).
Earley CJ, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee PC, Allen R.
Sleep Med. 2014 Nov;15(11):1288-301. doi: 10.1016/j.sleep.2014.05.009. Epub 2014 Jun 16.
PMID: 25201131 [PubMed – in process]
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2.Prevalence of restless legs syndrome in an urban population of eastern Africa (Tanzania).
Burtscher C, Baxmann A, Kassubek J, Hornyak M, Matuja W, Schmutzhard E, Winkler AS.
J Neurol Sci. 2014 Nov 15;346(1-2):121-7. doi: 10.1016/j.jns.2014.08.007. Epub 2014 Aug 14.
PMID: 25179877 [PubMed – in process]
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3.Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study.
Chang Y, Chang HW, Song H, Ku J, Earley CJ, Allen RP, Cho YW.
Clin Imaging. 2015 Jan-Feb;39(1):20-5. doi: 10.1016/j.clinimag.2014.07.010. Epub 2014 Aug 2.
PMID: 25176196 [PubMed – in process]
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4.Painful Restless Legs Syndrome: A Severe, Burning Form of the Disease.
Karroum EG, Golmard JL, Leu-Semenescu S, Arnulf I.
Clin J Pain. 2014 Aug 27. [Epub ahead of print]
PMID: 25167326 [PubMed – as supplied by publisher]
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5.The effect of vitamin D supplements on the severity of restless legs syndrome.
Wali S, Shukr A, Boudal A, Alsaiari A, Krayem A.
Sleep Breath. 2014 Aug 23. [Epub ahead of print]
PMID: 25148866 [PubMed – as supplied by publisher]
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6.Rotigotine transdermal system: developing continuous dopaminergic delivery to treat Parkinson’s disease and restless legs syndrome.
Benitez A, Edens H, Fishman J, Moran K, Asgharnejad M.
Ann N Y Acad Sci. 2014 Nov;1329:45-66. doi: 10.1111/nyas.12508. Epub 2014 Aug 21. Review.
PMID: 25145951 [PubMed – indexed for MEDLINE]
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7.Effect of sensory stimuli on restless legs syndrome: a randomized crossover study.
Rozeman AD, Ottolini T, Grootendorst DC, Vogels OJ, Rijsman RM.
J Clin Sleep Med. 2014 Aug 15;10(8):893-6. doi: 10.5664/jcsm.3964.
PMID: 25126036 [PubMed – in process] Free PMC Article
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8.Restless leg syndrome and sleep quality in lumbar radiculopathy patients.
Kocabicak E, Terzi M, Akpinar K, Paksoy K, Cebeci I, Iyigun O.
Behav Neurol. 2014;2014:245358. doi: 10.1155/2014/245358. Epub 2014 Jul 8.
PMID: 25110396 [PubMed – in process] Free PMC Article
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9.Mood disorders in restless legs syndrome (Willis-Ekbom disease).
Becker PM, Sharon D.
J Clin Psychiatry. 2014 Jul;75(7):e679-94. doi: 10.4088/JCP.13r08692. Review.
PMID: 25093484 [PubMed – indexed for MEDLINE] Free Article
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10.Profile of altered brain iron acquisition in restless legs syndrome.
Connor JR, Ponnuru P, Wang XS, Patton SM, Allen RP, Earley CJ.
Brain. 2011 Apr;134(Pt 4):959-68. doi: 10.1093/brain/awr012. Epub 2011 Mar 11.
PMID: 21398376 [PubMed – indexed for MEDLINE] Free PMC Article
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11.Gray matter anomalies in anterior cingulate cortex as a correlate of depressive symptoms in drug-naïve idiopathic restless legs syndrome.
Pan PL, Dai ZY, Shang HF, Xiao PR, Dong CS, Song WG, Zhou GL, Zhong JG, Shi HC.
Neuroscience. 2014 Sep 26;277:1-5. doi: 10.1016/j.neuroscience.2014.06.045. Epub 2014 Jun 30.
PMID: 24993478 [PubMed – in process]
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12.New treatment options for the management of restless leg syndrome.
Toro BE.
J Neurosci Nurs. 2014 Aug;46(4):227-32. doi: 10.1097/JNN.0000000000000068.
PMID: 24992148 [PubMed – in process]
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13.An update on restless legs syndrome (Willis-Ekbom disease): clinical features, pathogenesis and treatment.
Garcia-Borreguero D, Williams AM.
Curr Opin Neurol. 2014 Aug;27(4):493-501. doi: 10.1097/WCO.0000000000000117. Review.
PMID: 24978636 [PubMed – indexed for MEDLINE]
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14.Differentiating nocturnal leg cramps and restless legs syndrome.
Rana AQ, Khan F, Mosabbir A, Ondo W.
Expert Rev Neurother. 2014 Jul;14(7):813-8. doi: 10.1586/14737175.2014.927734. Epub 2014 Jun 14. Review.
PMID: 24931546 [PubMed – indexed for MEDLINE]
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15.Quality of life in patients with primary restless leg syndrome: community-based study.
Svetel MV, Jovic JS, Pekmezovic TD, Kostic VS.
Neurol Sci. 2015 Feb 13. [Epub ahead of print]
PMID: 25677847 [PubMed – as supplied by publisher]
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16.Restless legs syndrome in end stage renal disease patients on haemodialysis.
Haider I, Anees M, Shahid SA.
Pak J Med Sci. 2014 Nov-Dec;30(6):1209-12. doi: 10.12669/pjms.306.5691.
PMID: 25674109 [PubMed] Free PMC Article
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17.Sleep patterns and sleep disturbances across pregnancy.
Mindell JA, Cook RA, Nikolovski J.
Sleep Med. 2015 Jan 5. pii: S1389-9457(14)00499-7. doi: 10.1016/j.sleep.2014.12.006. [Epub ahead of print]
PMID: 25666847 [PubMed – as supplied by publisher]
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18.Blood withdrawal affects iron store dynamics in primates with consequences on monoaminergic system function.
Hyacinthe C, De Deurwaerdere P, Thiollier T, Li Q, Bezard E, Ghorayeb I.
Neuroscience. 2015 Feb 4. pii: S0306-4522(15)00115-3. doi: 10.1016/j.neuroscience.2015.01.057. [Epub ahead of print]
PMID: 25662508 [PubMed – as supplied by publisher]
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19.Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.
Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Hauck Newman A.
Bioorg Med Chem. 2015 Jan 17. pii: S0968-0896(15)00033-4. doi: 10.1016/j.bmc.2015.01.017. [Epub ahead of print]
PMID: 25650314 [PubMed – as supplied by publisher]
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20.Non-pharmacological interventions for improving sleep quality in patients on dialysis: systematic review and meta-analysis.
Yang B, Xu J, Xue Q, Wei T, Xu J, Ye C, Mei C, Mao Z.
Sleep Med Rev. 2014 Dec 10;23C:68-82. doi: 10.1016/j.smrv.2014.11.005. [Epub ahead of print] Review.
PMID: 25645131 [PubMed – as supplied by publisher]
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21.Restless legs syndrome and hypothyroidism.
Rodríguez Martín C, Miranda Riaño S, Celorrio San Miguel M, Prieto de Paula JM.
Rev Clin Esp. 2015 Jan 29. pii: S0014-2565(14)00471-8. doi: 10.1016/j.rce.2014.12.007. [Epub ahead of print] English, Spanish. No abstract available.
PMID: 25640256 [PubMed – as supplied by publisher]
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22.Presenting features of idiopathic versus secondary restless legs syndrome in pregnancy.
Miri S, Rohani M, Vahdat M, Kashanian M, Sariri E, Zamani B, Shahidi GA.
Iran J Neurol. 2014 Oct 6;13(4):241-4.
PMID: 25632338 [PubMed] Free PMC Article
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23.An Evidence-based Analysis of the Association between Periodic Leg Movements during Sleep and Arousals in Restless Legs Syndrome.
Ferri R, Rundo F, Zucconi M, Manconi M, Bruni O, Ferini-Strambi L, Fulda S.
Sleep. 2015 Jan 12. pii: sp-00630-14. [Epub ahead of print]
PMID: 25581922 [PubMed – as supplied by publisher]
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24.Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug-naïve restless legs syndrome: a proof-of-concept clinical trial.
Koo YS, Kim SM, Lee C, Lee BU, Moon YJ, Cho YW, Im CH, Choi JW, Kim KH, Jung KY.
Sleep Med. 2014 Dec 2. pii: S1389-9457(14)00472-9. doi: 10.1016/j.sleep.2014.07.032. [Epub ahead of print]
PMID: 25576136 [PubMed – as supplied by publisher]
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25.Association Between Restless Legs Syndrome and Adult ADHD in a German Community-Based Sample.
Roy M, de Zwaan M, Tuin I, Philipsen A, Brähler E, Müller A.
J Atten Disord. 2015 Jan 2. pii: 1087054714561291. [Epub ahead of print]
PMID: 25555628 [PubMed – as supplied by publisher]
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26.Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation.
Picchietti DL, Hensley JG, Bainbridge JL, Lee KA, Manconi M, McGregor JA, Silver RM, Trenkwalder C, Walters AS; International Restless Legs Syndrome Study Group (IRLSSG).
Sleep Med Rev. 2014 Nov 4. pii: S1087-0792(14)00119-1. doi: 10.1016/j.smrv.2014.10.009. [Epub ahead of print] Review.
PMID: 25553600 [PubMed – as supplied by publisher]
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27.Direct comparison of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome and restless legs syndrome.
Lanza G, Lanuzza B, Aricò D, Cantone M, Cosentino FI, Pennisi M, Bella R, Pennisi G, Ferri R.
Sleep Med. 2015 Jan;16(1):138-42. doi: 10.1016/j.sleep.2014.08.016. Epub 2014 Nov 13.
PMID: 25534710 [PubMed – in process]
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28.Pramipexole for Chinese people with primary restless legs syndrome: a 12-week multicenter, randomized, double-blind study.
Zhang J, Liu B, Zheng Y, Chu T, Yang Z.
Sleep Med. 2015 Jan;16(1):181-5. doi: 10.1016/j.sleep.2014.09.015. Epub 2014 Nov 28.
PMID: 25533540 [PubMed – in process]
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29.Efficacy of the Low-Dose Saccharum Iron Treatment of Idiopathic Restless Legs Syndrome.
Zhang X, Chen WW, Huang WJ.
Panminerva Med. 2014 Dec 22. [Epub ahead of print]
PMID: 25532586 [PubMed – as supplied by publisher]
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30.Spontaneous aching pain and peculiar involuntary movements: a case report of painful legs and moving toes and review of the literature.
Fan YY, Xu Y, Gao XG.
Case Rep Med. 2014;2014:581402. doi: 10.1155/2014/581402. Epub 2014 Nov 3.
PMID: 25530763 [PubMed] Free PMC Article
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31.Neurocognitive function in patients with idiopathic Restless Legs Syndrome before and after treatment with dopamine-agonist.
Galbiati A, Marelli S, Giora E, Zucconi M, Oldani A, Ferini-Strambi L.
Int J Psychophysiol. 2014 Dec 13. pii: S0167-8760(14)01667-5. doi: 10.1016/j.ijpsycho.2014.12.005. [Epub ahead of print]
PMID: 25514234 [PubMed – as supplied by publisher]
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32.What patients do to counteract the symptoms of Willis-Ekbom disease (RLS/WED): Effect of gender and severity of illness.
Gupta R, Goel D, Ahmed S, Dhar M, Lahan V.
Ann Indian Acad Neurol. 2014 Oct;17(4):405-8. doi: 10.4103/0972-2327.144010.
PMID: 25506161 [PubMed] Free PMC Article
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33.Design and validation of a periodic leg movement detector.
Moore H 4th, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E.
PLoS One. 2014 Dec 9;9(12):e114565. doi: 10.1371/journal.pone.0114565. eCollection 2014.
PMID: 25489744 [PubMed – in process] Free PMC Article
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34.Association of Restless Legs Syndrome, Pain, and Mood Disorders in Parkinson’s Disease.
Rana AQ, Qureshi AR, Rahman L, Jesudasan A, Hafez KK, Rana MA.
Int J Neurosci. 2014 Dec 3:1-13. [Epub ahead of print]
PMID: 25469455 [PubMed – as supplied by publisher]
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35.Restless legs syndrome in multiple sclerosis.
Sieminski M, Losy J, Partinen M.
Sleep Med Rev. 2014 Oct 12. pii: S1087-0792(14)00101-4. doi: 10.1016/j.smrv.2014.10.002. [Epub ahead of print] Review.
PMID: 25454673 [PubMed – as supplied by publisher]
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36.Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease).
Mehmood T, Auerbach M, Earley CJ, Allen RP.
Sleep Med. 2014 Dec;15(12):1473-6. doi: 10.1016/j.sleep.2014.08.012. Epub 2014 Sep 10.
PMID: 25441748 [PubMed – in process]
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37.The cerebellum and sleep.
DelRosso LM, Hoque R.
Neurol Clin. 2014 Nov;32(4):893-900. doi: 10.1016/j.ncl.2014.07.003. Epub 2014 Oct 24.
PMID: 25439287 [PubMed – in process]
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38.Structural brain lesions and restless legs syndrome: a cross-sectional population-based study.
Rist PM, Tzourio C, Elbaz A, Soumaré A, Dufouil C, Mazoyer B, Kurth T.
BMJ Open. 2014 Nov 24;4(11):e005938. doi: 10.1136/bmjopen-2014-005938.
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39.Increased nocturnal periodic limb movements in rheumatoid arthritis patients meeting questionnaire diagnostic criteria for restless legs syndrome.
Taylor-Gjevre RM, Gjevre JA, Nair BV.
BMC Musculoskelet Disord. 2014 Nov 18;15:378. doi: 10.1186/1471-2474-15-378.
PMID: 25406507 [PubMed – in process] Free PMC Article
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40.Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson’s disease: a pilot study.
Dragan EM, Chen Z, Ondo WG.
Int J Neurosci. 2014 Dec 18. [Epub ahead of print]
PMID: 25405536 [PubMed – as supplied by publisher]
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41.The gut microbiome and the brain.
Galland L.
J Med Food. 2014 Dec;17(12):1261-72. doi: 10.1089/jmf.2014.7000.
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42.A novel model for brain iron uptake: introducing the concept of regulation.
Simpson IA, Ponnuru P, Klinger ME, Myers RL, Devraj K, Coe CL, Lubach GR, Carruthers A, Connor JR.
J Cereb Blood Flow Metab. 2015 Jan;35(1):48-57. doi: 10.1038/jcbfm.2014.168. Epub 2014 Oct 15.
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43.A review of current treatment strategies for restless legs syndrome (Willis-Ekbom disease).
Klingelhoefer L, Cova I, Gupta S, Chaudhuri KR.
Clin Med. 2014 Oct;14(5):520-4. doi: 10.7861/clinmedicine.14-5-520.
PMID: 25301914 [PubMed – in process]
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44.Is autonomic nervous system involved in restless legs syndrome during wakefulness?
Izzi F, Placidi F, Romigi A, Lauretti B, Marfia GA, Mercuri NB, Marciani MG, Rocchi C.
Sleep Med. 2014 Nov;15(11):1392-7. doi: 10.1016/j.sleep.2014.06.022. Epub 2014 Aug 22.
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