PHT Live – Subclinical Hypothyroidism and its Implications on Health

Today we are discussing subclinical hypothyroidism and its implications on health.
Over the years, there has been discrepancy in the medical literature as to when a patient should be treated for hypothyroidism based on the severity of their lab tests.  In today’s broadcast, we will discuss this in detail as well as the fact that “borderline” cases of hypothyroidism can be highly clinically significant to heart disease, and new literature is supporting that subclinical hypothyroidism may have an impact on depression, metabolic syndrome, and miscarriages.
Please enjoy, and send us your questions.  Please forward us any questions here on our website or go to our Power Health Facebook page


1.Screening and Treatment of Thyroid Dysfunction: An Evidence Review for the U.S. Preventive Services Task Force.
Rugge JB, Bougatsos C, Chou R.
Ann Intern Med. 2014 Oct 28. doi: 10.7326/M14-1456. [Epub ahead of print]
PMID: 25347444 [PubMed – as supplied by publisher]
Related citations
2.Subclinical hypothyroidism and cardiovascular risk.
Vayá A, Giménez C, Sarnago A, Alba A, Rubio O, Hernández-Mijares A, Cámara R.
Clin Hemorheol Microcirc. 2014 Jan 1;58(1):1-7. doi: 10.3233/CH-141871.
PMID: 25339098 [PubMed – in process]
Related citations
3.Different Effects Of Fenofibrate On Metabolic And Cardiovascular Risk Factors In Mixed Dyslipidemic Women With Normal Thyroid Function And Subclinical Hypothyroidism.
Krysiak R, Gilowski W, Szkrobka W, Okopien B.
Cardiovasc Ther. 2014 Oct 7. doi: 10.1111/1755-5922.12095. [Epub ahead of print]
PMID: 25290818 [PubMed – as supplied by publisher]
Related citations
4.[Thyroid dysfunction in pregnancy].
Führer D, Mann K, Feldkamp J, Krude H, Spitzweg C, Kratzsch J, Schott M.
Dtsch Med Wochenschr. 2014 Oct;139(42):2148-52. doi: 10.1055/s-0034-1387300. Epub 2014 Oct 7. German.
PMID: 25289925 [PubMed – in process]
Related citations
5.Does fasting or postprandial state affect thyroid function testing?
Nair R, Mahadevan S, Muralidharan RS, Madhavan S.
Indian J Endocrinol Metab. 2014 Sep;18(5):705-7. doi: 10.4103/2230-8210.139237.
PMID: 25285290 [PubMed] Free PMC Article
Related citations
6.Thyroid dysfunction in Indian children with down syndrome.
Dayal D, Jain P, Panigrahi I, Bhattacharya A, Sachdeva N.
Indian Pediatr. 2014 Sep 8;51(9):751-2.
PMID: 25228616 [PubMed – in process] Free Article
Related citations
7.Polycystic ovary syndrome and chronic autoimmune thyroiditis.
Novais JD, Benetti-Pinto CL, Garmes HM, Menezes Jales R, Juliato CR.
Gynecol Endocrinol. 2014 Sep 11:1-4. [Epub ahead of print]
PMID: 25211537 [PubMed – as supplied by publisher]
Related citations
8.Serum thyrotropin is positively correlated with the metabolic syndrome components of obesity and dyslipidemia in chinese adolescents.
Zhang J, Jiang R, Li L, Li P, Li X, Wang Z, Li L, Teng W.
Int J Endocrinol. 2014;2014:289503. doi: 10.1155/2014/289503. Epub 2014 Aug 21.
PMID: 25214835 [PubMed] Free PMC Article
Related citations
9.Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity pre-conception and in pregnancy.
Chan S, Boelaert K.
Clin Endocrinol (Oxf). 2014 Sep 9. doi: 10.1111/cen.12605. [Epub ahead of print]
PMID: 25200555 [PubMed – as supplied by publisher]
Related citations
10.[The incidence of hypothyroidism symptoms and risk factors for cardiovascular events in subclinical hypothyroidism].
Krysicki M, Jaworska M, Popowicz B, Jankiewicz-Wika J, Klencki M, S?owi?ska-Klencka D.
Pol Merkur Lekarski. 2014 Jul;37(217):10-6. Polish.
PMID: 25154193 [PubMed – indexed for MEDLINE]
Related citations
11.Alteration of lipid profile in subclinical hypothyroidism: a meta-analysis.
Liu XL, He S, Zhang SF, Wang J, Sun XF, Gong CM, Zheng SJ, Zhou JC, Xu J.
Med Sci Monit. 2014 Aug 14;20:1432-41. doi: 10.12659/MSM.891163.
PMID: 25124461 [PubMed – in process] Free PMC Article
Related citations
12.Thyroid Axis Dysregulation During In Vitro Fertilization in Hypothyroid-Treated Patients.
Busnelli A, Somigliana E, Benaglia L, Sarais V, Ragni G, Fedele L.
Thyroid. 2014 Sep 5. [Epub ahead of print]
PMID: 25089619 [PubMed – as supplied by publisher]
Related citations
13.Maternal Subclinical Hypothyroidism, Thyroid Autoimmunity, and the Risk of Miscarriage: A Prospective Cohort Study.
Liu H, Shan Z, Li C, Mao J, Xie X, Wang W, Fan C, Wang H, Zhang H, Han C, Wang X, Liu X, Fan Y, Bao S, Teng W.
Thyroid. 2014 Sep 17. [Epub ahead of print]
PMID: 25087688 [PubMed – as supplied by publisher]
Related citations
14.Prevalence of subclinical hypothyroidism in pregnant women in tehran-iran.
Yassaee F, Farahani M, Abadi AR.
Int J Fertil Steril. 2014 Jul;8(2):163-6. Epub 2014 Jul 8.
PMID: 25083181 [PubMed] Free PMC Article
Related citations
15.The effect of metformin on the hypothalamic-pituitary-thyroid axis in women with polycystic ovary syndrome and subclinical hypothyroidism.
Krysiak R, Okopien B.
J Clin Pharmacol. 2014 Jul 30. doi: 10.1002/jcph.373. [Epub ahead of print]
PMID: 25079765 [PubMed – as supplied by publisher]
Related citations
16.Thyroid hormones and coronary artery calcification in euthyroid men and women.
Zhang Y, Kim BK, Chang Y, Ryu S, Cho J, Lee WY, Rhee EJ, Kwon MJ, Rampal S, Zhao D, Pastor-Barriuso R, Lima JA, Shin H, Guallar E.
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2128-34. doi: 10.1161/ATVBAHA.114.303889. Epub 2014 Jul 24.
PMID: 25060795 [PubMed – indexed for MEDLINE]
Related citations
17.Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis.
Posadas-Romero C, Jorge-Galarza E, Posadas-Sánchez R, Acuña-Valerio J, Juárez-Rojas JG, Kimura-Hayama E, Medina-Urrutia A, Cardoso-Saldaña GC.
Eur J Endocrinol. 2014 Sep;171(3):319-25. doi: 10.1530/EJE-14-0150.
PMID: 25053728 [PubMed – indexed for MEDLINE]
Related citations
18.Cognitive function and quality of life in mild thyroid hormone deficiency.
Tognini S, Pasqualetti G, Calsolaro V, Polini A, Monzani F.
Recent Pat Endocr Metab Immune Drug Discov. 2014;8(2):124-34.
PMID: 25052000 [PubMed – in process]
Related citations
19.The biochemical prognostic factors of subclinical hypothyroidism.
Lee MW, Shin DY, Kim KJ, Hwang S, Lee EJ.
Endocrinol Metab (Seoul). 2014 Jun;29(2):154-62. doi: 10.3803/EnM.2014.29.2.154. Epub 2014 Jun 26.
PMID: 25031888 [PubMed] Free PMC Article
Related citations
20.Depressive symptoms and major depressive disorder in patients affected by subclinical hypothyroidism: a cross-sectional study.
Demartini B, Ranieri R, Masu A, Selle V, Scarone S, Gambini O.
J Nerv Ment Dis. 2014 Aug;202(8):603-7. doi: 10.1097/NMD.0000000000000168.
PMID: 25010109 [PubMed – indexed for MEDLINE]
Related citations
21.Non-alcoholic fatty liver disease and thyroid dysfunction: a systematic review.
Eshraghian A, Hamidian Jahromi A.
World J Gastroenterol. 2014 Jul 7;20(25):8102-9. doi: 10.3748/wjg.v20.i25.8102.
PMID: 25009382 [PubMed – in process] Free PMC Article
Related citations
22.Arrhythmia and thyroid dysfunction.
Marrakchi S, Kanoun F, Idriss S, Kammoun I, Kachboura S.
Herz. 2014 Jul 4. [Epub ahead of print]
PMID: 24990773 [PubMed – as supplied by publisher]
Related citations
23.Assessment of Thyroid Disorders and Autoimmunity in Patients with Rheumatic Diseases.
Acay A, Ulu MS, Ahsen A, Eroglu S, Ozuguz U, Yuksel S, Acarturk G.
Endocr Metab Immune Disord Drug Targets. 2014 Jun 26. [Epub ahead of print]
PMID: 24965722 [PubMed – as supplied by publisher]
Related citations
24.Cardiovascular disease and thyroid function.
Faber J, Selmer C.
Front Horm Res. 2014;43:45-56. doi: 10.1159/000360558. Epub 2014 Jun 10.
PMID: 24943297 [PubMed – in process]
Related citations
25.Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: an individual participant data analysis.
Collet TH, Bauer DC, Cappola AR, Asvold BO, Weiler S, Vittinghoff E, Gussekloo J, Bremner A, den Elzen WP, Maciel RM, Vanderpump MP, Cornuz J, Dörr M, Wallaschofski H, Newman AB, Sgarbi JA, Razvi S, Völzke H, Walsh JP, Aujesky D, Rodondi N; Thyroid Studies Collaboration.
J Clin Endocrinol Metab. 2014 Sep;99(9):3353-62. doi: 10.1210/jc.2014-1250. Epub 2014 Jun 10.
PMID: 24915118 [PubMed – in process]
Related citations
26.Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies.
Mamtani M, Kulkarni H, Dyer TD, Almasy L, Mahaney MC, Duggirala R, Comuzzie AG, Samollow PB, Blangero J, Curran JE.
BMC Endocr Disord. 2014 Jun 10;14:46. doi: 10.1186/1472-6823-14-46.
PMID: 24913450 [PubMed – in process] Free PMC Article
Related citations
27.Subclinical hypothyroidism: Controversies to consensus.
Raza SA, Mahmood N.
Indian J Endocrinol Metab. 2013 Dec;17(Suppl 3):S636-42. doi: 10.4103/2230-8210.123555. Review.
PMID: 24910826 [PubMed] Free PMC Article
Related citations

Leave a Comment

Your email address will not be published. Required fields are marked *