PHT Live – New Data on Restless Leg Syndrome

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This week we are doing an update on Restless Leg Syndrome.  RLS is a disabling condition where individuals attempt to sit down or go to bed in the evening, and they experience an intense sensation to move their legs.  Often, they have to get up and move around, preventing them from getting adequate sleep.  Most RLS sufferers describe it as being miserable.
Today we will present some of the new data regarding RLS, and potential new treatment options.
Please tune in and enjoy.  Please forward us any questions here on our website or go to our Power Health Facebook page


1.Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease).
Earley CJ, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee PC, Allen R.
Sleep Med. 2014 Jun 16. pii: S1389-9457(14)00237-8. doi: 10.1016/j.sleep.2014.05.009. [Epub ahead of print] Review.
PMID: 25201131 [PubMed – as supplied by publisher]
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2.Prevalence of restless legs syndrome in an urban population of eastern Africa (Tanzania).
Burtscher C, Baxmann A, Kassubek J, Hornyak M, Matuja W, Schmutzhard E, Winkler AS.
J Neurol Sci. 2014 Aug 14. pii: S0022-510X(14)00520-6. doi: 10.1016/j.jns.2014.08.007. [Epub ahead of print]
PMID: 25179877 [PubMed – as supplied by publisher]
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3.Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study.
Chang Y, Chang HW, Song H, Ku J, Earley CJ, Allen RP, Cho YW.
Clin Imaging. 2014 Aug 2. pii: S0899-7071(14)00178-8. doi: 10.1016/j.clinimag.2014.07.010. [Epub ahead of print]
PMID: 25176196 [PubMed – as supplied by publisher]
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4.Painful Restless Legs Syndrome: A Severe, Burning Form of the Disease.
Karroum EG, Golmard JL, Leu-Semenescu S, Arnulf I.
Clin J Pain. 2014 Aug 27. [Epub ahead of print]
PMID: 25167326 [PubMed – as supplied by publisher]
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5.The effect of vitamin D supplements on the severity of restless legs syndrome.
Wali S, Shukr A, Boudal A, Alsaiari A, Krayem A.
Sleep Breath. 2014 Aug 23. [Epub ahead of print]
PMID: 25148866 [PubMed – as supplied by publisher]
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6.Rotigotine transdermal system: developing continuous dopaminergic delivery to treat Parkinson’s disease and restless legs syndrome.
Benitez A, Edens H, Fishman J, Moran K, Asgharnejad M.
Ann N Y Acad Sci. 2014 Aug 21. doi: 10.1111/nyas.12508. [Epub ahead of print]
PMID: 25145951 [PubMed – as supplied by publisher]
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7.Effect of sensory stimuli on restless legs syndrome: a randomized crossover study.
Rozeman AD, Ottolini T, Grootendorst DC, Vogels OJ, Rijsman RM.
J Clin Sleep Med. 2014 Aug 15;10(8):893-6. doi: 10.5664/jcsm.3964.
PMID: 25126036 [PubMed – in process]
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8.Restless leg syndrome and sleep quality in lumbar radiculopathy patients.
Kocabicak E, Terzi M, Akpinar K, Paksoy K, Cebeci I, Iyigun O.
Behav Neurol. 2014;2014:245358. doi: 10.1155/2014/245358. Epub 2014 Jul 8.
PMID: 25110396 [PubMed – in process] Free PMC Article
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9.Mood disorders in restless legs syndrome (Willis-Ekbom Disease).
Becker PM, Sharon D.
J Clin Psychiatry. 2014 Jul;75(7):e679-94. doi: 10.4088/JCP.13r08692.
PMID: 25093484 [PubMed – in process] Free Article
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10.Profile of altered brain iron acquisition in restless legs syndrome.
Connor JR, Ponnuru P, Wang XS, Patton SM, Allen RP, Earley CJ.
Brain. 2011 Apr;134(Pt 4):959-68. doi: 10.1093/brain/awr012. Epub 2011 Mar 11.
PMID: 21398376 [PubMed – indexed for MEDLINE] Free PMC Article
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11.Gray matter anomalies in anterior cingulate cortex as a correlate of depressive symptoms in drug-naïve idiopathic restless legs syndrome.
Pan PL, Dai ZY, Shang HF, Xiao PR, Dong CS, Song WG, Zhou GL, Zhong JG, Shi HC.
Neuroscience. 2014 Jun 30;277C:1-5. doi: 10.1016/j.neuroscience.2014.06.045. [Epub ahead of print]
PMID: 24993478 [PubMed – as supplied by publisher]
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12.New treatment options for the management of restless leg syndrome.
Toro BE.
J Neurosci Nurs. 2014 Aug;46(4):227-32. doi: 10.1097/JNN.0000000000000068.
PMID: 24992148 [PubMed – in process]
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13.An update on restless legs syndrome (Willis-Ekbom disease): clinical features, pathogenesis and treatment.
Garcia-Borreguero D, Williams AM.
Curr Opin Neurol. 2014 Aug;27(4):493-501. doi: 10.1097/WCO.0000000000000117.
PMID: 24978636 [PubMed – in process]
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14.Differentiating nocturnal leg cramps and restless legs syndrome.
Rana AQ, Khan F, Mosabbir A, Ondo W.
Expert Rev Neurother. 2014 Jul;14(7):813-8. doi: 10.1586/14737175.2014.927734. Epub 2014 Jun 14.
PMID: 24931546 [PubMed – in process]
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