PHT Live – Fibromyalgia, the Problem is in Your Nerves, Not Your Muscles

Today we are discussing “Fibromyalgia, the Problem is in Your Nerves, Not Your Muscles.”  There are many misconceptions about Fibromyalgia, one being that it is a muscle disorder.  In today’s broadcast we will discuss how this condition is primarily a neurologic disorder caused by immune system abnormalities as well as chronically elevated stress hormones.
Please enjoy, and send us your questions.  Please forward us any questions here on our website or go to our Power Health Facebook page
1.Microneurographic recording from unmyelinated nerve fibers in neurological disorders: An update.
Donadio V, Liguori R.
Clin Neurophysiol. 2014 Oct 17. pii: S1388-2457(14)00549-5. doi: 10.1016/j.clinph.2014.10.009. [Epub ahead of print] Review.
PMID: 25457652 [PubMed – as supplied by publisher]
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2.Reduction of Intraepidermal Nerve Fiber Density (IENFD) in the skin biopsies of patients with fibromyalgia: A controlled study.
Kosmidis ML, Koutsogeorgopoulou L, Alexopoulos H, Mamali I, Vlachoyiannopoulos PG, Voulgarelis M, Moutsopoulos HM, Tzioufas AG, Dalakas MC.
J Neurol Sci. 2014 Dec 15;347(1-2):143-7. doi: 10.1016/j.jns.2014.09.035. Epub 2014 Sep 28.
PMID: 25304055 [PubMed – in process]
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3.Small nerve fiber involvement in patients referred for fibromyalgia.
Giannoccaro MP, Donadio V, Incensi A, Avoni P, Liguori R.
Muscle Nerve. 2014 May;49(5):757-9. doi: 10.1002/mus.24156. Epub 2014 Jan 28.
PMID: 24469976 [PubMed – indexed for MEDLINE]
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4.Hyperexcitable C nociceptors in fibromyalgia.
Serra J, Collado A, Solà R, Antonelli F, Torres X, Salgueiro M, Quiles C, Bostock H.
Ann Neurol. 2014 Feb;75(2):196-208. doi: 10.1002/ana.24065. Epub 2014 Feb 12.
PMID: 24243538 [PubMed – indexed for MEDLINE]
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5.Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia.
Oaklander AL, Herzog ZD, Downs HM, Klein MM.
Pain. 2013 Nov;154(11):2310-6. doi: 10.1016/j.pain.2013.06.001. Epub 2013 Jun 5.
PMID: 23748113 [PubMed – indexed for MEDLINE] Free PMC Article
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6.Small fibre pathology in patients with fibromyalgia syndrome.
Üçeyler N, Zeller D, Kahn AK, Kewenig S, Kittel-Schneider S, Schmid A, Casanova-Molla J, Reiners K, Sommer C.
Brain. 2013 Jun;136(Pt 6):1857-67. doi: 10.1093/brain/awt053. Epub 2013 Mar 9.
PMID: 23474848 [PubMed – indexed for MEDLINE] Free Article
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7.Chronic pain as a manifestation of potassium channel-complex autoimmunity.
Klein CJ, Lennon VA, Aston PA, McKeon A, Pittock SJ.
Neurology. 2012 Sep 11;79(11):1136-44. doi: 10.1212/WNL.0b013e3182698cab. Epub 2012 Aug 15.
PMID: 22895588 [PubMed – indexed for MEDLINE] Free PMC Article
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8.Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI.
Cagnie B, Coppieters I, Denecker S, Six J, Danneels L, Meeus M.
Semin Arthritis Rheum. 2014 Aug;44(1):68-75. doi: 10.1016/j.semarthrit.2014.01.001. Epub 2014 Jan 8.
PMID: 24508406 [PubMed – in process]
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9.Attentional bias toward negative information in patients with fibromyalgia syndrome.
Duschek S, Werner NS, Limbert N, Winkelmann A, Montoya P.
Pain Med. 2014 Apr;15(4):603-12. doi: 10.1111/pme.12360. Epub 2014 Jan 21.
PMID: 24447855 [PubMed – in process]
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10.Fibromyalgia and chronic widespread pain in autoimmune thyroid disease.
Ahmad J, Tagoe CE.
Clin Rheumatol. 2014 Jul;33(7):885-91. doi: 10.1007/s10067-014-2490-9. Epub 2014 Jan 18.
PMID: 24435355 [PubMed – in process]
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11.Segmental hyperalgesia to mechanical stimulus in interstitial cystitis/bladder pain syndrome: evidence of central sensitization.
Lai HH, Gardner V, Ness TJ, Gereau RW 4th.
J Urol. 2014 May;191(5):1294-9. doi: 10.1016/j.juro.2013.11.099. Epub 2013 Dec 6.
PMID: 24316091 [PubMed – indexed for MEDLINE]
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12.Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Smith SC, Wagner MS.
Neuro Endocrinol Lett. 2014;35(3):198-201. Review.
PMID: 24977967 [PubMed – in process]
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13.Structural alterations in brainstem of fibromyalgia syndrome patients correlate with sensitivity to mechanical pressure.
Fallon N, Alghamdi J, Chiu Y, Sluming V, Nurmikko T, Stancak A.
Neuroimage Clin. 2013 Aug 9;3:163-70. doi: 10.1016/j.nicl.2013.07.011. eCollection 2013.
PMID: 24179860 [PubMed] Free PMC Article
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14.Review of overlap between thermoregulation and pain modulation in fibromyalgia.
Larson AA, Pardo JV, Pasley JD.
Clin J Pain. 2014 Jun;30(6):544-55. doi: 10.1097/AJP.0b013e3182a0e383.
PMID: 23887348 [PubMed – in process]
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