PHT Live – Berberine – A Powerful Natural Compound

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Today we are doing our broadcast on the effects of Berberine.  Berberine has been used for millennia in Asia in the treatment of diarrhea and gastrointestinal problems.  In the 1990’s it was observed to have powerful effects on reducing blood sugar in diabetic patients.  Since that time Berberine has been shown to decrease blood sugar nearly on par with other anti-diabetic medications as well as reducing cholesterol levels.  There are many other effects of berberine that are being observed in mice, however the limitations at this time mainly center around the fact that Berberine is not well absorbed.  Therefore, we have read several articles where pharmaceutical researchers have attempted to modify berberine so that it can be absorbed more effectively.  Please enjoy this broadcast, as in the coming years you will likely hear more about this powerful natural compound.

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References:

1. Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus.
Li Z, Geng YN, Jiang JD, Kong WJ.
Evid Based Complement Alternat Med. 2014;2014:289264. Epub 2014 Feb 11. Review.
PMID: 24669227 [PubMed – as supplied by publisher] Free PMC Article
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2. Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics.
Li R, Wu J, He Y, Hai L, Wu Y.
Bioorg Med Chem Lett. 2014 Apr 1;24(7):1762-5. doi: 10.1016/j.bmcl.2014.02.032. Epub 2014 Feb 21.
PMID: 24613165 [PubMed – in process]
Related citations
3. Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability.
Zhaojie M, Ming Z, Shengnan W, Xiaojia B, Hatch GM, Jingkai G, Li C.
Int J Pharm. 2014 Jun 5;467(1-2):50-9. doi: 10.1016/j.ijpharm.2014.03.017. Epub 2014 Mar 5.
PMID: 24607213 [PubMed – in process]
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4. Berberine ameliorates experimental autoimmune neuritis by suppressing both cellular and humoral immunity.
Li H, Li XL, Zhang M, Xu H, Wang CC, Wang S, Duan RS.
Scand J Immunol. 2014 Jan;79(1):12-9. doi: 10.1111/sji.12123.
PMID: 24354407 [PubMed – indexed for MEDLINE]
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5. Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles.
Xue M, Yang MX, Zhang W, Li XM, Gao DH, Ou ZM, Li ZP, Liu SH, Li XJ, Yang SY.
Int J Nanomedicine. 2013;8:4677-87. doi: 10.2147/IJN.S51262. Epub 2013 Dec 5.
PMID: 24353417 [PubMed – in process] Free PMC Article
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6. Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials.
Derosa G, Maffioli P, Cicero AF.
Expert Opin Biol Ther. 2012 Aug;12(8):1113-24. doi: 10.1517/14712598.2012.704014. Review.
PMID: 22780092 [PubMed – indexed for MEDLINE]
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7. Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes.
Di Pierro F, Putignano P, Villanova N, Montesi L, Moscatiello S, Marchesini G.
Clin Pharmacol. 2013 Nov 19;5:167-74. doi: 10.2147/CPAA.S54308. eCollection 2013.
PMID: 24277991 [PubMed] Free PMC Article
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8. Alkaloids as aldose reductase inhibitors, with special reference to berberine.
Gupta S, Singh N, Jaggi AS.
J Altern Complement Med. 2014 Mar;20(3):195-205. doi: 10.1089/acm.2013.0088. Epub 2013 Nov 15.
PMID: 24236461 [PubMed – in process]
Related citations
9. Tissue distribution of berberine and its metabolites after oral administration in rats.
Tan XS, Ma JY, Feng R, Ma C, Chen WJ, Sun YP, Fu J, Huang M, He CY, Shou JW, He WY, Wang Y, Jiang JD.
PLoS One. 2013 Oct 31;8(10):e77969. doi: 10.1371/journal.pone.0077969. eCollection 2013.
PMID: 24205048 [PubMed – in process] Free PMC Article
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10. Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in ?-cells via TLR4-independent JNK/NF-?B pathway.
Wang Y.
Pharm Biol. 2013 Nov 5. [Epub ahead of print]
PMID: 24188583 [PubMed – as supplied by publisher]
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11. Learning from berberine: Treating chronic diseases through multiple targets.
Yao J, Kong W, Jiang J.
Sci China Life Sci. 2013 Oct 30. [Epub ahead of print]
PMID: 24174332 [PubMed – as supplied by publisher]
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12. Berberine ameliorate oxidative stress and astrogliosis in the hippocampus of STZ-induced diabetic rats.
Moghaddam HK, Baluchnejadmojarad T, Roghani M, Khaksari M, Norouzi P, Ahooie M, Mahboobi F.
Mol Neurobiol. 2014 Apr;49(2):820-6. doi: 10.1007/s12035-013-8559-7. Epub 2013 Oct 10.
PMID: 24113841 [PubMed – in process]
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13. Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth.
Hsu YY, Tseng YT, Lo YC.
Toxicol Appl Pharmacol. 2013 Nov 1;272(3):787-96. doi: 10.1016/j.taap.2013.08.008. Epub 2013 Aug 15.
PMID: 23954465 [PubMed – indexed for MEDLINE]
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14. Tetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein function.
Shan YQ, Zhu YP, Pang J, Wang YX, Song DQ, Kong WJ, Jiang JD.
Biol Pharm Bull. 2013;36(10):1562-9. Epub 2013 Aug 8.
PMID: 23924821 [PubMed – indexed for MEDLINE] Free Article
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15. The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment.
An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M.
Clin Endocrinol (Oxf). 2014 Mar;80(3):425-31. doi: 10.1111/cen.12294. Epub 2013 Aug 9.
PMID: 23869585 [PubMed – in process]
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16. Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats.
Shan CY, Yang JH, Kong Y, Wang XY, Zheng MY, Xu YG, Wang Y, Ren HZ, Chang BC, Chen LM.
J Endocrinol. 2013 Jul 29;218(3):255-62. doi: 10.1530/JOE-13-0184. Print 2013 Sep.
PMID: 23757509 [PubMed – indexed for MEDLINE]
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17. Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy.
Kim SO, Kim HJ.
J Med Food. 2013 Jun;16(6):511-7. doi: 10.1089/jmf.2012.2648. Epub 2013 Jun 4.
PMID: 23734996 [PubMed – indexed for MEDLINE]
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18. Berberine chloride improved synaptic plasticity in STZ induced diabetic rats.
Moghaddam HK, Baluchnejadmojarad T, Roghani M, Goshadrou F, Ronaghi A.
Metab Brain Dis. 2013 Sep;28(3):421-8. doi: 10.1007/s11011-013-9411-5. Epub 2013 May 3.
PMID: 23640014 [PubMed – indexed for MEDLINE]
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19. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis.
Dong H, Wang N, Zhao L, Lu F.
Evid Based Complement Alternat Med. 2012;2012:591654. doi: 10.1155/2012/591654. Epub 2012 Oct 15.
PMID: 23118793 [PubMed] Free PMC Article
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20. Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic ?-cell.
Shen N, Huan Y, Shen ZF.
Eur J Pharmacol. 2012 Nov 5;694(1-3):120-6. doi: 10.1016/j.ejphar.2012.07.052. Epub 2012 Aug 29.
PMID: 22955013 [PubMed – indexed for MEDLINE]
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