Lyme Disease: It is time for a new approach to this problem

In today’s broadcast we will be discussing a very important topic, Lyme disease. In the field of Lyme disease there are two  different philosophies for treating the condition, with one proposing that chronic Lyme does exist while the other states that the disease should be cured after the first 30 days. However, many chronic Lyme suffers continue to have  symptoms and as a result may be frustrated with lack of progress. In today’s  broadcast we will be discussing brand-new information,  information that is probably going to change the way the medical community looks at Lyme disease, as to why chronic Lyme suffers are not getting better and how this can translate into improved treatment outcomes. Please enjoy!
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1.Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.
Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC.
J Autoimmun. 2016 Feb 24. pii: S0896-8411(16)30007-5. doi: 10.1016/j.jaut.2016.02.005. [Epub ahead of print]
PMID: 26922382 [PubMed – as supplied by publisher]
2.Nervous system Lyme disease, chronic Lyme disease, and none of the above.
Halperin JJ.
Acta Neurol Belg. 2016 Mar;116(1):1-6. doi: 10.1007/s13760-015-0541-x. Epub 2015 Sep 16.
PMID: 26377699 [PubMed – in process]
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3.“Lyme”: Chronic Fatigue Syndrome by Another Name?
Barbour AG.
Clin Infect Dis. 2016 Jan 1;62(1):134-5. doi: 10.1093/cid/civ699. Epub 2015 Aug 12. No abstract available.
PMID: 26270685 [PubMed – in process]
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4.Chronic Lyme disease: a review.
Marques A.
Infect Dis Clin North Am. 2008 Jun;22(2):341-60, vii-viii. doi: 10.1016/j.idc.2007.12.011. Review.
PMID: 18452806 [PubMed – indexed for MEDLINE] Free PMC Article
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5.Reinfection versus relapse in patients with lyme disease: not enough evidence.
Stricker RB, Corson AF, Johnson L.
Clin Infect Dis. 2008 Mar 15;46(6):950; author reply 950-1. doi: 10.1086/528871. No abstract available.
PMID: 18288903 [PubMed – indexed for MEDLINE] Free Article
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6.Natural killer cells in chronic Lyme disease.
Stricker RB, Winger EE.
Clin Vaccine Immunol. 2009 Nov;16(11):1704; author reply 1704-6. doi: 10.1128/CVI.00260-09. No abstract available.
PMID: 19880717 [PubMed – indexed for MEDLINE] Free PMC Article
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7.Lyme neuroborreliosis-epidemiology, diagnosis and management.
Koedel U, Fingerle V, Pfister HW.
Nat Rev Neurol. 2015 Aug;11(8):446-56. doi: 10.1038/nrneurol.2015.121. Epub 2015 Jul 28. Review.
PMID: 26215621 [PubMed – in process]
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8.Subjective health complaints are not associated with tick bites or antibodies to Borrelia burgdorferi sensu lato in blood donors in western Norway: a cross-sectional study.
Hjetland R, Reiso H, Ihlebæk C, Nilsen RM, Grude N, Ulvestad E.
BMC Public Health. 2015 Jul 14;15:657. doi: 10.1186/s12889-015-2026-5.
PMID: 26169496 [PubMed – indexed for MEDLINE] Free PMC Article
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9.Lyme Disease Diagnosed by Alternative Methods: A Phenotype Similar to That of Chronic Fatigue Syndrome.
Patrick DM, Miller RR, Gardy JL, Parker SM, Morshed MG, Steiner TS, Singer J, Shojania K, Tang P; Complex Chronic Disease Study Group.
Clin Infect Dis. 2015 Oct 1;61(7):1084-91. doi: 10.1093/cid/civ470. Epub 2015 Jun 16.
PMID: 26082507 [PubMed – in process]
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10.Chronic Lyme disease: misconceptions and challenges for patient management.
Halperin JJ.
Infect Drug Resist. 2015 May 15;8:119-28. doi: 10.2147/IDR.S66739. eCollection 2015. Review.
PMID: 26028977 [PubMed] Free PMC Article
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11.Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells.
Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K.
Antimicrob Agents Chemother. 2015 Aug;59(8):4616-24. doi: 10.1128/AAC.00864-15. Epub 2015 May 26.
PMID: 26014929 [PubMed – in process] Free PMC Article
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12.Chronic lymphomonocytic meningoencephalitis, oligoarthritis and erythema nodosum: report of Baggio-Yoshinari syndrome of long and relapsing evolution.
Rosa Neto NS, Gauditano G, Yoshinari NH.
Rev Bras Reumatol. 2014 Mar-Apr;54(2):148-51. English, Portuguese.
PMID: 24878862 [PubMed – indexed for MEDLINE] Free Article
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13.Prevention of lyme disease: promising research or sisyphean task?
Krupka M, Zachova K, Weigl E, Raska M.
Arch Immunol Ther Exp (Warsz). 2011 Aug;59(4):261-75. doi: 10.1007/s00005-011-0128-z. Epub 2011 Jun 3. Review.
PMID: 21633917 [PubMed – indexed for MEDLINE]
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14.The diagnostic spectrum in patients with suspected chronic Lyme neuroborreliosis–the experience from one year of a university hospital’s Lyme neuroborreliosis outpatients clinic.
Djukic M, Schmidt-Samoa C, Nau R, von Steinbüchel N, Eiffert H, Schmidt H.
Eur J Neurol. 2011 Apr;18(4):547-55. doi: 10.1111/j.1468-1331.2010.03229.x. Epub 2010 Oct 27.
PMID: 20977545 [PubMed – indexed for MEDLINE]
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15.Antibodies as predictors of complex autoimmune diseases and cancer.
Vojdani A.
Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):553-66. Erratum in: Int J Immunopathol Pharmacol. 2008 Oct-Dec;21(4):following 1051.
PMID: 18831922 [PubMed – indexed for MEDLINE]
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16.Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.
Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, Fowler V, Auwaerter PG, Nigrovic LE.
Clin Infect Dis. 2015 Nov 1;61(9):1374-80. doi: 10.1093/cid/civ584. Epub 2015 Jul 20.
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17.Laboratory diagnosis of Lyme disease: advances and challenges.
Marques AR.
Infect Dis Clin North Am. 2015 Jun;29(2):295-307. doi: 10.1016/j.idc.2015.02.005. Review.
PMID: 25999225 [PubMed – indexed for MEDLINE]
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18.Relevance of chronic lyme disease to family medicine as a complex multidimensional chronic disease construct: a systematic review.
Borgermans L, Goderis G, Vandevoorde J, Devroey D.
Int J Family Med. 2014;2014:138016. doi: 10.1155/2014/138016. Epub 2014 Nov 24. Review.
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19.Test of 259 serums from patients with arthritis or neurological symptoms confirmed existence of Lyme disease in Hainan province, China.
Zhang L, Zhu X, Hou X, Geng Z, Chen H, Hao Q.
Int J Clin Exp Med. 2015 Jun 15;8(6):9531-6. eCollection 2015.
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20.Diagnostic Value of Recombinant Tp0821 Protein in Serodiagnosis for Syphilis.
Xie Y, Xu M, Wang C, Xiao J, Xiao Y, Jiang C, You X, Zhao F, Zeng T, Liu S, Kuang X, Wu Y.
Lett Appl Microbiol. 2016 Feb 8. doi: 10.1111/lam.12554. [Epub ahead of print]
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  1. There is no evidence that Lyme disease is transmitted from person-to-person. For example, a person cannot get infected from touching, kissing, or having sex with a person who has Lyme disease.

  2. In the broadcast we were attempting to present the two sides of the argument. The International Lyme and Associated Disease Societies stance is such that Borrelia can be transferred in the fashion you referred to however we fully understand that this is not the common viewpoint held by infectious disease specialists. Therefore, we were mentioning it to illustrate the disparity between the two sides.

  3. I also listened to your video about Hashimoto’s, which I have. Could you provide a link to what a baseline diet is?
    Thank you

  4. We start all patients off basically on an autoimmune paleo diet and then tweak the diet from there depending on the patient’s response. What we have found is that there is no one diet that is perfect for everyone as different people seem to react to different things, but that is the best place to start.

  5. YES! Chronic infections are linked with many of our diagnoses! So glad there are some open minded doctors in this town who aren’t afraid of the truth and take the time to explore based on clinical findings. Thank You, Thank You!

  6. Thank you. I was dx’d with Lyme from my chiropractor. I had been chasing my health for 10 yrs. We used lots of probiotics, digestive enzymes and adrenal support. I got well! this all makes sense!

  7. Just watched your video “Lyme Disease: It is time for a new approach to this problem”, regarding how it is an autoimmune system problem. A bit confused, does that mean I can be cured? Have some questions on that part of it. Is this autoimmune state,,curable?
    Will I keep feeling good and out of the woods of sickness? Will I always have to worry about all of the symptoms returning?
    Never had ANY abx treatment. Only use natural remedies; supplements, vitamins and my favorite essential oils.(about 24 in every bath) They’ve boosted my immune system and I Do feel better. I do oil pulling too, everyday and it has made a drastic change in how I feel. I’ve been up working and cleaning my house even. A huge change from being stuck in bed..vomiting, headaches, etc. The Apple Cider Vinegar(Bragg’s only) twice daily stopped my vomiting. Mix it with Honey. 🙂
    My LLMD sent my blood-work to Igenex, but he knew by my symptoms, that I had Lyme. I was called by Igenex and dx’d with Lyme, Babesia and Bartonella. Pulled the tick off of me in ’08 and my weight sky-rocketed to 199. The tick had been there 2 days and since I have nerve damage, I didn’t feel it on the base of my head/neck, but it was fully engorged and thought that I just had something in my hair. I almost puked, when I pulled it off and saw it squirming. 😮
    On top of adrenal insufficiency, hyperthyroidism(cysts on Thyroid too), every layer of my back is affected with compression fractures, herniations, a protrusion and a tear, but the docs don’t believe that I need surgery..which is good news. It still is painful and on strong medications(Fentanyl patch, Norco, Gabapentin, Valium(for sleep) and Zanaflex(for muscle tremors).
    Wonder if the Lyme has gotten into my spinal cord-CNS, since I have been experiencing so much pain. Do you think that is possibility?
    Thank you guys docs…for all the hard-work that you are putting in, to get answers. 🙂

  8. Karen R Elmore

    Just a quick mention that I did change my diet about 2 yrs ago because of having candida, although I never took abx. for the Lyme. Still don’t know what caused that, but sure that it was because my diet consisted of mostly junk food-pizza and hamburgers. Changed everything. Starting using Stevia for my sweeetner… no sugar, no flour or no junk food and started to feel a ton better.
    I try to eat good whole food now and try to never eat processed food at all. IT DOES make a difference in how we feel. We are what we eat!! 🙂

  9. Hi Karen,

    Most autoimmune problems cannot be cured but they can be calmed down. That is our emphasis and typically patient’s are rather pleased with the results. We are glad you are feeling better and let us know if you have other questions.

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