What Makes Us Different

The landscape of the alternative therapy world is constantly changing. In today’s broadcast we will be discussing our philosophies on chronic pain and autoimmune disease as well as how we approach these issues uniquely.

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References:
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Li X, Atkinson MA.
Pediatr Diabetes. 2015 Nov;16(7):485-92. doi: 10.1111/pedi.12305. Epub 2015 Aug 13. Review.
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2. Imaging the leaky gut.
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Gastroenterology. 2014 Nov;147(5):952-4. doi: 10.1053/j.gastro.2014.09.027. Epub 2014 Sep 27. No abstract available.
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3. Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut.
Maes M, Kubera M, Leunis JC, Berk M.
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4. Gut-Brain: Major Depressive Disorder, Hypothalamic Dysfunction, and High Calcium Score Associated With Leaky Gut.
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9. The gut microbiota influences blood-brain barrier permeability in mice.
Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyás B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S.
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10. The effects of moderate exercise on chronic stress-induced intestinal barrier dysfunction and antimicrobial defense.
Luo B, Xiang D, Nieman DC, Chen P.
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11. Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury.
Zhang X, Jiang X.
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12. Gastrointestinal Symptoms and Altered Intestinal Permeability Induced by Combat Training Are Associated with Distinct Metabotypic Changes.
Phua LC, Wilder-Smith CH, Tan YM, Gopalakrishnan T, Wong RK, Li X, Kan ME, Lu J, Keshavarzian A, Chan EC.
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13. Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders.
Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP.
Front Cell Neurosci. 2015 Oct 14;9:392. doi: 10.3389/fncel.2015.00392. eCollection 2015. Review.
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14. Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury.
Lang Y, Fu F, Sun D, Xi C, Chen F.
PLoS One. 2015 Jul 17;10(7):e0133215. doi: 10.1371/journal.pone.0133215. eCollection 2015.
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15. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications.
Fasano A.
Clin Gastroenterol Hepatol. 2012 Oct;10(10):1096-100. doi: 10.1016/j.cgh.2012.08.012. Epub 2012 Aug 16. Review.
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16. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins.
Fasano A, Nataro JP.
Adv Drug Deliv Rev. 2004 Apr 19;56(6):795-807. Review.
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17. Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.
Nouri M, Bredberg A, Weström B, Lavasani S.
PLoS One. 2014 Sep 3;9(9):e106335. doi: 10.1371/journal.pone.0106335. eCollection 2014.
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18. Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study.
Chen CH, Lin CL, Kao CH.
PLoS One. 2016 Jan 5;11(1):e0144589. doi: 10.1371/journal.pone.0144589. eCollection 2016.
PMID: 26731277 [PubMed – in process] Free PMC Article
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19. Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome.
Maes M, Leunis JC, Geffard M, Berk M.
Neuro Endocrinol Lett. 2014;35(6):445-53.
PMID: 25433843 [PubMed – indexed for MEDLINE]
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20. Gluten Psychosis: Confirmation of a New Clinical Entity.
Lionetti E, Leonardi S, Franzonello C, Mancardi M, Ruggieri M, Catassi C.
Nutrients. 2015 Jul 8;7(7):5532-9. doi: 10.3390/nu7075235.
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21. Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial.
Shahbazkhani B, Sadeghi A, Malekzadeh R, Khatavi F, Etemadi M, Kalantri E, Rostami-Nejad M, Rostami K.
Nutrients. 2015 Jun 5;7(6):4542-54. doi: 10.3390/nu7064542.
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22. Celiac and non-celiac gluten sensitivity: a review on the association with schizophrenia and mood disorders.
Porcelli B, Verdino V, Bossini L, Terzuoli L, Fagiolini A.
Auto Immun Highlights. 2014 Oct 16;5(2):55-61. doi: 10.1007/s13317-014-0064-0. eCollection 2014 Sep. Review.
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23. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity.
Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A.
Nutrients. 2015 Feb 27;7(3):1565-76. doi: 10.3390/nu7031565.
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24. Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters.
Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, Chihara N, Tomita A, Sato W, Kim SW, Morita H, Hattori M, Yamamura T.
PLoS One. 2015 Sep 14;10(9):e0137429. doi: 10.1371/journal.pone.0137429. eCollection 2015.
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25. [Multiple sclerosis and microbiota. From genome to metagenome?].
Hohlfeld R, Wekerle H.
Nervenarzt. 2015 Aug;86(8):925-33. doi: 10.1007/s00115-014-4248-7. German.
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26. The gut microbiome in multiple sclerosis.
Mielcarz DW, Kasper LH.
Curr Treat Options Neurol. 2015 Apr;17(4):344. doi: 10.1007/s11940-015-0344-7.
PMID: 25843302 [PubMed]
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27. Gut commensalism, cytokines, and central nervous system demyelination.
Telesford K, Ochoa-Repáraz J, Kasper LH.
J Interferon Cytokine Res. 2014 Aug;34(8):605-14. doi: 10.1089/jir.2013.0134. Review.
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28. Peripheral aetiopathogenic drivers and mediators of Parkinson’s disease and co-morbidities: role of gastrointestinal microbiota.
Dobbs SM, Dobbs RJ, Weller C, Charlett A, Augustin A, Taylor D, Ibrahim MA, Bjarnason I.
J Neurovirol. 2016 Feb;22(1):22-32. doi: 10.1007/s13365-015-0357-8. Epub 2015 Jun 20.
PMID: 26092111 [PubMed – in process] Free PMC Article
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29. Altered fecal microbiota composition in patients with major depressive disorder.
Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, Wang W, Tang W, Tan Z, Shi J, Li L, Ruan B.
Brain Behav Immun. 2015 Aug;48:186-94. doi: 10.1016/j.bbi.2015.03.016. Epub 2015 Apr 13.
PMID: 25882912 [PubMed – indexed for MEDLINE] Free Article
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30. Gut/brain axis and the microbiota.
Mayer EA, Tillisch K, Gupta A.
J Clin Invest. 2015 Mar 2;125(3):926-38. doi: 10.1172/JCI76304. Epub 2015 Feb 17. Review.
PMID: 25689247 [PubMed – indexed for MEDLINE] Free PMC Article
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31. The microbiome and psoriatic arthritis.
Eppinga H, Konstantinov SR, Peppelenbosch MP, Thio HB.
Curr Rheumatol Rep. 2014 Mar;16(3):407. doi: 10.1007/s11926-013-0407-2. Review.
PMID: 24474190 [PubMed – indexed for MEDLINE]
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32. Th17 cells in immunity and autoimmunity.
Bedoya SK, Lam B, Lau K, Larkin J 3rd.
Clin Dev Immunol. 2013;2013:986789. doi: 10.1155/2013/986789. Epub 2013 Dec 26. Review.
PMID: 24454481 [PubMed – indexed for MEDLINE] Free PMC Article
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33. Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model.
Van Praet L, Van den Bosch FE, Jacques P, Carron P, Jans L, Colman R, Glorieus E, Peeters H, Mielants H, De Vos M, Cuvelier C, Elewaut D.
Ann Rheum Dis. 2013 Mar;72(3):414-7. doi: 10.1136/annrheumdis-2012-202135. Epub 2012 Nov 8.
PMID: 23139267 [PubMed – indexed for MEDLINE]
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34. The life and death of epithelia during inflammation: lessons learned from the gut.
Koch S, Nusrat A.
Annu Rev Pathol. 2012;7:35-60. doi: 10.1146/annurev-pathol-011811-120905. Epub 2011 Aug 12. Review.
PMID: 21838548 [PubMed – indexed for MEDLINE]
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35. Triggering psoriasis: the role of infections and medications.
Fry L, Baker BS.
Clin Dermatol. 2007 Nov-Dec;25(6):606-15. Review.
PMID: 18021899 [PubMed – indexed for MEDLINE]
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36. Rheumatoid arthritis is caused by a Proteus urinary tract infection.
Ebringer A, Rashid T.
APMIS. 2014 May;122(5):363-8. doi: 10.1111/apm.12154. Epub 2013 Aug 29. Review.
PMID: 23992372 [PubMed – indexed for MEDLINE]
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37. Autoimmunity in Rheumatic Diseases Is Induced by Microbial Infections via Crossreactivity or Molecular Mimicry.
Rashid T, Ebringer A.
Autoimmune Dis. 2012;2012:539282. doi: 10.1155/2012/539282. Epub 2012 Feb 20.
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38. Therapy: Gut-mediated autoimmune arthritis treated with antibiotics.
Ebringer A.
Nat Rev Rheumatol. 2010 Nov;6(11):622-3. doi: 10.1038/nrrheum.2010.163.
PMID: 21037561 [PubMed – indexed for MEDLINE]
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39. The influence of fast and vegetarian diet on parameters of nutritional status in patients with rheumatoid arthritis.
Haugen MA, Kjeldsen-Kragh J, Skakkebaek N, Landaas S, Sjaastad O, Movinkel P, Førre O.
Clin Rheumatol. 1993 Mar;12(1):62-9.
PMID: 8467614 [PubMed – indexed for MEDLINE]
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40. A pilot study of the effect of an elemental diet in the management of rheumatoid arthritis.
Haugen MA, Kjeldsen-Kragh J, Førre O.
Clin Exp Rheumatol. 1994 May-Jun;12(3):275-9.
PMID: 8070160 [PubMed – indexed for MEDLINE]
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41. Vegetarian diet for patients with rheumatoid arthritis: can the clinical effects be explained by the psychological characteristics of the patients?
Kjeldsen-Kragh J, Haugen M, Førre O, Laache H, Malt UF.
Br J Rheumatol. 1994 Jun;33(6):569-75.
PMID: 8205407 [PubMed – indexed for MEDLINE]
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42. Changes of faecal flora in rheumatoid arthritis during fasting and one-year vegetarian diet.
Peltonen R, Kjeldsen-Kragh J, Haugen M, Tuominen J, Toivanen P, Førre O, Eerola E.
Br J Rheumatol. 1994 Jul;33(7):638-43.
PMID: 8019792 [PubMed – indexed for MEDLINE]
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43. Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review.
Müller H, de Toledo FW, Resch KL.
Scand J Rheumatol. 2001;30(1):1-10. Review.
PMID: 11252685 [PubMed – indexed for MEDLINE]
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44. Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet.
Kjeldsen-Kragh J, Rashid T, Dybwad A, Sioud M, Haugen M, Førre O, Ebringer A.
Ann Rheum Dis. 1995 Mar;54(3):221-4.
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45. Rheumatoid arthritis treated with vegetarian diets.
Kjeldsen-Kragh J.
Am J Clin Nutr. 1999 Sep;70(3 Suppl):594S-600S.
PMID: 10479237 [PubMed – indexed for MEDLINE] Free Article
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46. Microbiome therapy gains market traction.
Reardon S.
Nature. 2014 May 15;509(7500):269-70. doi: 10.1038/509269a. No abstract available.
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47. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.
Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolo V, Pamer EG, Abramson SB, Huttenhower C, Littman DR.
Elife. 2013 Nov 5;2:e01202. doi: 10.7554/eLife.01202.
PMID: 24192039 [PubMed – indexed for MEDLINE] Free PMC Article
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48. A gut feeling about arthritis.
Mathis D.
Elife. 2013 Nov 5;2:e01608. doi: 10.7554/eLife.01608.
PMID: 24192040 [PubMed – indexed for MEDLINE] Free PMC Article
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49. Rheumatoid arthritis patients have elevated antibodies to cross-reactive and non cross-reactive antigens from Proteus microbes.
Rashid T, Jayakumar KS, Binder A, Ellis S, Cunningham P, Ebringer A.
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):259-67.
PMID: 17543151 [PubMed – indexed for MEDLINE]
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50. Rheumatoid arthritis is linked to Proteus–the evidence.
Rashid T, Ebringer A.
Clin Rheumatol. 2007 Jul;26(7):1036-43. Epub 2007 Jan 6. Review.
PMID: 17206398 [PubMed – indexed for MEDLINE]
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51. Rheumatoid arthritis, Proteus, anti-CCP antibodies and Karl Popper.
Ebringer A, Rashid T, Wilson C.
Autoimmun Rev. 2010 Feb;9(4):216-23. doi: 10.1016/j.autrev.2009.10.006. Epub 2009 Nov 4.
PMID: 19895906 [PubMed – indexed for MEDLINE]
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52. Role of Rho kinase signal pathway in inflammatory bowel disease.
Huang Y, Xiao S, Jiang Q.
Int J Clin Exp Med. 2015 Mar 15;8(3):3089-97. eCollection 2015. Review.
PMID: 26064197 [PubMed] Free PMC Article
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53. Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.
C?tan? CS, Berindan Neagoe I, Cozma V, Magda? C, T?b?ran F, Dumitra?cu DL.
World J Gastroenterol. 2015 May 21;21(19):5823-30. doi: 10.3748/wjg.v21.i19.5823. Review.
PMID: 26019446 [PubMed – indexed for MEDLINE] Free PMC Article
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54. Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis.
Maranduba CM, De Castro SB, de Souza GT, Rossato C, da Guia FC, Valente MA, Rettore JV, Maranduba CP, de Souza CM, do Carmo AM, Macedo GC, Silva Fde S.
J Immunol Res. 2015;2015:931574. doi: 10.1155/2015/931574. Epub 2015 Feb 22. Review.
PMID: 25759850 [PubMed – indexed for MEDLINE] Free PMC Article
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55. Clinical Presentation and Outcomes of Autoimmune Hepatitis in Inflammatory Bowel Disease.
DeFilippis EM, Kumar S.
Dig Dis Sci. 2015 Oct;60(10):2873-80. doi: 10.1007/s10620-015-3699-4. Epub 2015 May 22. Review.
PMID: 25999245 [PubMed – indexed for MEDLINE]
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56. Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis.
Lin R, Zhou L, Zhang J, Wang B.
Int J Clin Exp Pathol. 2015 May 1;8(5):5153-60. eCollection 2015.
PMID: 26191211 [PubMed – indexed for MEDLINE] Free PMC Article
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57. Altered biliary epithelial cell and monocyte responses to lipopolysaccharide as a TLR ligand in patients with primary biliary cirrhosis.
Zhao J, Zhao S, Zhou G, Liang L, Guo X, Mao P, Zhou X, Wang H, Nan Y, Xu D, Yu J.
Scand J Gastroenterol. 2011 Apr;46(4):485-94. doi: 10.3109/00365521.2010.539624. Epub 2011 Jan 28.
PMID: 21275501 [PubMed – indexed for MEDLINE]
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58. Migraine associated with gastrointestinal disorders: review of the literature and clinical implications.
van Hemert S, Breedveld AC, Rovers JM, Vermeiden JP, Witteman BJ, Smits MG, de Roos NM.
Front Neurol. 2014 Nov 21;5:241. doi: 10.3389/fneur.2014.00241. eCollection 2014. Review.
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59. The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study.
de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S.
Benef Microbes. 2015;6(5):641-6. doi: 10.3920/BM2015.0003. Epub 2015 Apr 22.
PMID: 25869282 [PubMed – in process]
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60. The link between ankylosing spondylitis, Crohn’s disease, Klebsiella, and starch consumption.
Rashid T, Wilson C, Ebringer A.
Clin Dev Immunol. 2013;2013:872632. doi: 10.1155/2013/872632. Epub 2013 May 27. Review.
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61. Association of gut inflammation with increased serum IgA class Klebsiella antibody concentrations in patients with axial ankylosing spondylitis (AS): implication for different aetiopathogenetic mechanisms for axial and peripheral AS?
Mäki-Ikola O, Leirisalo-Repo M, Turunen U, Granfors K.
Ann Rheum Dis. 1997 Mar;56(3):180-3.
PMID: 9135221 [PubMed – indexed for MEDLINE] Free PMC Article
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62. Gut inflammation in the spondyloarthropathies.
Mielants H, De Keyser F, Baeten D, Van den Bosch F.
Curr Rheumatol Rep. 2005 Jun;7(3):188-94. Review.
PMID: 15918994 [PubMed – indexed for MEDLINE]
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63. Effects of Probiotic Supplementation on Pancreatic ?-cell Function and C-reactive Protein in Women with Polycystic Ovary Syndrome: A Randomized Double-blind Placebo-controlled Clinical Trial.
Shoaei T, Heidari-Beni M, Tehrani HG, Feizi A, Esmaillzadeh A, Askari G.
Int J Prev Med. 2015 Mar 24;6:27. doi: 10.4103/2008-7802.153866. eCollection 2015.
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64. Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood-brain barrier cells toward enhanced prostaglandin E(2) signaling.
Vasilache AM, Qian H, Blomqvist A.
Brain Behav Immun. 2015 Aug;48:31-41. doi: 10.1016/j.bbi.2015.02.003. Epub 2015 Feb 9.
PMID: 25678162 [PubMed – indexed for MEDLINE]
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65. Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph.
Hirose K, Hartsock JJ, Johnson S, Santi P, Salt AN.
J Assoc Res Otolaryngol. 2014 Oct;15(5):707-19. doi: 10.1007/s10162-014-0476-6. Epub 2014 Jun 21.
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66. Calorie restriction attenuates lipopolysaccharide (LPS)-induced microglial activation in discrete regions of the hypothalamus and the subfornical organ.
Radler ME, Hale MW, Kent S.
Brain Behav Immun. 2014 May;38:13-24. doi: 10.1016/j.bbi.2013.11.014. Epub 2013 Dec 1.
PMID: 24291211 [PubMed – indexed for MEDLINE]
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67. Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure.
Chastre A, Bélanger M, Nguyen BN, Butterworth RF.
Liver Int. 2014 Mar;34(3):353-61. doi: 10.1111/liv.12252. Epub 2013 Aug 2.
PMID: 23910048 [PubMed – indexed for MEDLINE]
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68. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics.
Geurts L, Neyrinck AM, Delzenne NM, Knauf C, Cani PD.

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