Post Concussion Syndrome: Why You Still Have Symptoms

In today’s broadcast will be discussing some of the newest research regarding post concussion syndrome, and how this research is further validating this condition. We will discuss neuroimaging as well as laboratory tests being used to look for the biomarker of this condition.

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References:
1. Head-Eye Vestibular Motion Therapy Affects the Mental and Physical Health of Severe Chronic Postconcussion Patients.
Carrick FR, Clark JF, Pagnacco G, Antonucci MM, Hankir A, Zaman R, Oggero E.
Front Neurol. 2017 Aug 22;8:414. doi: 10.3389/fneur.2017.00414. eCollection 2017.
PMID: 28878731 [PubMed] Free PMC Article
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2. Sub-Symptomatic Aerobic Exercise for Patients with Post-Concussion Syndrome: A Critically Appraised Topic.
Ritter KG, Hussey MJ, Valovich McLeod TC.
J Sport Rehabil. 2017 Sep 27:1-14. doi: 10.1123/jsr.2017-0159. [Epub ahead of print]
PMID: 28952858 [PubMed – as supplied by publisher]
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3. Does the fear avoidance model explain persistent symptoms after traumatic brain injury?
Wijenberg MLM, Stapert SZ, Verbunt JA, Ponsford JL, Van Heugten CM.
Brain Inj. 2017 Oct 5:1-8. doi: 10.1080/02699052.2017.1366551. [Epub ahead of print]
PMID: 28980825 [PubMed – as supplied by publisher]
4. Prognostic value of S-100ß protein for prediction of post-concussion symptoms following a mild traumatic brain injury: systematic review and meta-analysis.
Mercier E, Tardif PA, Cameron P, Batomen Kuimi BL, Émond M, Moore L, Mitra B, Frenette J, de Guise E, Ouellet MC, Bordeleau M, Le Sage N.
J Neurotrauma. 2017 Oct 2. doi: 10.1089/neu.2017.5013. [Epub ahead of print]
PMID: 28969486 [PubMed – as supplied by publisher]
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5. Characteristics of patients included and enrolled in studies on the prognostic value of serum biomarkers for prediction of postconcussion symptoms following a mild traumatic brain injury: a systematic review.
Mercier E, Tardif PA, Emond M, Ouellet MC, de Guise É, Mitra B, Cameron P, Le Sage N.
BMJ Open. 2017 Sep 27;7(9):e017848. doi: 10.1136/bmjopen-2017-017848.
PMID: 28963310 [PubMed – in process] Free Article
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6. Preliminary validation of the WHODAS 2.0 for mild traumatic brain injury.
Snell D, Iverson GL, Panenka W, Silverberg ND.
J Neurotrauma. 2017 Sep 12. [Epub ahead of print]
PMID: 28895491 [PubMed – as supplied by publisher]
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7. CranioSacral Therapy and Visceral Manipulation: A New Treatment Intervention for Concussion Recovery.
Wetzler G, Roland M, Fryer-Dietz S, Dettmann-Ahern D.
Med Acupunct. 2017 Aug 1;29(4):239-248. doi: 10.1089/acu.2017.1222.
PMID: 28874926 [PubMed] Free PMC Article
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8. Assessing the accuracy of blood RNA profiles to identify patients with post-concussion syndrome: A pilot study in a military patient population.
Hardy JJ, Mooney SR, Pearson AN, McGuire D, Correa DJ, Simon RP, Meller R.
PLoS One. 2017 Sep 1;12(9):e0183113. doi: 10.1371/journal.pone.0183113. eCollection 2017.
PMID: 28863142 [PubMed – in process] Free PMC Article
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9. Characteristics of the King-Devick test in the assessment of concussed patients in the subacute and later stages after injury.
Subotic A, Ting WK, Cusimano MD.
PLoS One. 2017 Aug 31;12(8):e0183092. doi: 10.1371/journal.pone.0183092. eCollection 2017.
PMID: 28859119 [PubMed – in process] Free PMC Article
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10. The effect of an acute systemic inflammatory insult on the chronic effects of a single mild traumatic brain injury.
Collins-Praino LE, Arulsamy A, Katharesan V, Corrigan F.
Behav Brain Res2018 Jan 15;336:22-31. doi: 10.1016/j.bbr.2017.08.035. Epub 2017 Aug 30.
PMID: 28855139 [PubMed – in process]
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11. [Resting state fMRI study of emotional network in patients with postconcussion syndrome].
Zhang X, Qian RB, Fu XM, Lin B, Zhang D, Xia CS, Wei XP, Niu CS, Wang YH.
Zhonghua Yi Xue Za Zhi. 2017 Jul 4;97(25):1951-1955. doi: 10.3760/cma.j.issn.0376-2491.2017.25.007. Chinese.
PMID: 28693073 [PubMed – in process]
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12. Prevalence of Abnormal Magnetic Resonance Imaging Findings in Children with Persistent Symptoms after Pediatric Sports-Related Concussion.
Bonow RH, Friedman SD, Perez FA, Ellenbogen RG, Browd SR, Mac Donald CL, Vavilala MS, Rivara FP.
J Neurotrauma. 2017 Oct 1;34(19):2706-2712. doi: 10.1089/neu.2017.4970. Epub 2017 Jul 19.
PMID: 28490224 [PubMed – in process]
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13. Resting-State Functional Connectivity Alterations Associated with Six-Month Outcomes in Mild Traumatic Brain Injury.
Palacios EM, Yuh EL, Chang YS, Yue JK, Schnyer DM, Okonkwo DO, Valadka AB, Gordon WA, Maas AIR, Vassar M, Manley GT, Mukherjee P.
J Neurotrauma. 2017 Apr 15;34(8):1546-1557. doi: 10.1089/neu.2016.4752. Epub 2017 Jan 13.
PMID: 28085565 [PubMed – indexed for MEDLINE]
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14. Neuropsychological alterations and neuroradiological findings in patients with post-traumatic concussion: Results of a pilot study.
R?doi A, Poca MA, Cañas V, Cevallos JM, Membrado L, Saavedra MC, Vidal M, Martínez-Ricarte F, Sahuquillo J.
Neurologia. 2016 Dec 19. pii: S0213-4853(16)30218-3. doi: 10.1016/j.nrl.2016.10.003. [Epub ahead of print] English, Spanish.
PMID: 28007313 [PubMed – as supplied by publisher] Free Article
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15. Mild Traumatic Brain Injury: Longitudinal Study of Cognition, Functional Status, and Post-Traumatic Symptoms.
Dikmen S, Machamer J, Temkin N.
J Neurotrauma. 2017 Apr 15;34(8):1524-1530. doi: 10.1089/neu.2016.4618. Epub 2016 Dec 2.
PMID: 27785968 [PubMed – indexed for MEDLINE]
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16. Longitudinal Study of Postconcussion Syndrome: Not Everyone Recovers.
Hiploylee C, Dufort PA, Davis HS, Wennberg RA, Tartaglia MC, Mikulis D, Hazrati LN, Tator CH.
J Neurotrauma. 2017 Apr 15;34(8):1511-1523. doi: 10.1089/neu.2016.4677. Epub 2016 Nov 29.
PMID: 27784191 [PubMed – indexed for MEDLINE] Free PMC Article
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17. Diffusion Tensor Imaging Findings in Post-Concussion Syndrome Patients after Mild Traumatic Brain Injury: A Systematic Review.
Khong E, Odenwald N, Hashim E, Cusimano MD.
Front Neurol. 2016 Sep 19;7:156. eCollection 2016. Review.
PMID: 27698651 [PubMed] Free PMC Article
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18. Neurochemical Aftermath of Repetitive Mild Traumatic Brain Injury.
Shahim P, Tegner Y, Gustafsson B, Gren M, Ärlig J, Olsson M, Lehto N, Engström Å, Höglund K, Portelius E, Zetterberg H, Blennow K.
JAMA Neurol. 2016 Nov 1;73(11):1308-1315. doi: 10.1001/jamaneurol.2016.2038.
PMID: 27654934 [PubMed – indexed for MEDLINE]
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19. Post mTBI fatigue is associated with abnormal brain functional connectivity.
Nordin LE, Möller MC, Julin P, Bartfai A, Hashim F, Li TQ.
Sci Rep. 2016 Feb 16;6:21183. doi: 10.1038/srep21183.
PMID: 26878885 [PubMed – indexed for MEDLINE] Free PMC Article
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