Lyme Disease: Immune Suppression vs Autoimmune

In today’s broadcast we will discuss the most up-to-date literature regarding Lyme disease and it’s associations with immune suppression and how this affects testing for Borellia species. Furthermore, we will also discuss the current evidence regarding autoimmunity in Lyme patients and how this may translate into successful patient outcomes using a new paradigm for this illness.

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References:
1. Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection.
Elsner RA, Hastey CJ, Olsen KJ, Baumgarth N.
PLoS Pathog. 2015 Jul 2;11(7):e1004976. doi: 10.1371/journal.ppat.1004976. eCollection 2015 Jul.
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2. Lyme disease.
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3. Cerebrospinal fluid T-regulatory cells recognize Borrelia burgdorferi NAPA in chronic Lyme borreliosis.
Amedei A, Codolo G, Ozolins D, Ballerini C, Biagioli T, Jaunalksne I, Zilevica A, D Elios S, De Bernard M, D’ Elios MM.
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4. Spitting image: tick saliva assists the causative agent of Lyme disease in evading host skin’s innate immune response.
Hovius JW.
J Invest Dermatol. 2009 Oct;129(10):2337-9. doi: 10.1038/jid.2009.202.
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5. Is human granulocytic ehrlichiosis a new Lyme disease? Review and comparison of clinical, laboratory, epidemiological, and some biological features.
Dumler JS.
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6. Cellular immune findings in Lyme disease. Correlation with serum IgM and disease activity.
Moffat CM, Sigal LH, Steere AC, Freeman DH, Dwyer JM.
Am J Med. 1984 Oct;77(4):625-32.
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7. Cutting edge: T cell-mediated pathology in murine Lyme borreliosis.
McKisic MD, Redmond WL, Barthold SW.
J Immunol. 2000 Jun 15;164(12):6096-9.
PMID: 10843657 [PubMed – indexed for MEDLINE] Free Article
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8. ?-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli.
Bramwell KK, Mock K, Ma Y, Weis JH, Teuscher C, Weis JJ.
J Immunol. 2015 Aug 15;195(4):1647-56. doi: 10.4049/jimmunol.1500212. Epub 2015 Jul 13.
PMID: 26170381 [PubMed – indexed for MEDLINE] Free PMC Article
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9. Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis.
Vudattu NK, Strle K, Steere AC, Drouin EE.
Arthritis Rheum. 2013 Jun;65(6):1643-53. doi: 10.1002/art.37910.
PMID: 23450683 [PubMed – indexed for MEDLINE] Free PMC Article
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10. Cellular immune findings in Lyme disease.
Sigal LH, Moffat CM, Steere AC, Dwyer JM.
Yale J Biol Med. 1984 Jul-Aug;57(4):595-8.
PMID: 6240164 [PubMed – indexed for MEDLINE] Free PMC Article
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11. The outer surface protein A (OspA) vaccine against Lyme disease: efficacy in the rhesus monkey.
Philipp MT, Lobet Y, Bohm RP Jr, Roberts ED, Dennis VA, Gu Y, Lowrie RC Jr, Desmons P, Duray PH, England JD, Hauser P, Piesman J, Xu K.
Vaccine. 1997 Dec;15(17-18):1872-87.
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12. Lyme disease: a rigorous review of diagnostic criteria and treatment.
Borchers AT, Keen CL, Huntley AC, Gershwin ME.
J Autoimmun. 2015 Feb;57:82-115. doi: 10.1016/j.jaut.2014.09.004. Epub 2014 Oct 16. Review.
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13. [Lyme disease: how widespread is the problem?].
van der Horst HE.
Ned Tijdschr Geneeskd. 2014;158:A8175. Dutch.
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14. [Combatting Lyme disease].
Hovius JW, Sprong H.
Ned Tijdschr Geneeskd. 2014;158:A7986. Review. Dutch.
PMID: 25248736 [PubMed – indexed for MEDLINE]
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15. Long-term Assessment of Post-Treatment Symptoms in Patients With Culture-Confirmed Early Lyme Disease.
Weitzner E, McKenna D, Nowakowski J, Scavarda C, Dornbush R, Bittker S, Cooper D, Nadelman RB, Visintainer P, Schwartz I, Wormser GP.
Clin Infect Dis. 2015 Dec 15;61(12):1800-6. doi: 10.1093/cid/civ735. Epub 2015 Sep 18.
PMID: 26385994 [PubMed – indexed for MEDLINE] Free PMC Article
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16. Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis.
Kovalchuka L, Cvetkova S, Trofimova J, Eglite J, Gintere S, Lucenko I, Oczko-Grzesik B, Viksna L, Krumina A.
Int J Environ Res Public Health. 2016 Dec 1;13(12). pii: E1194.
PMID: 27916969 [PubMed – indexed for MEDLINE] Free PMC Article
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17. The Lyme disease vaccine–a public health perspective.
Shen AK, Mead PS, Beard CB.
Clin Infect Dis. 2011 Feb;52 Suppl 3:s247-52. doi: 10.1093/cid/ciq115. Review.
PMID: 21217171 [PubMed – indexed for MEDLINE]
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