Fatigue: Should You Get Tested for Addison’s Disease?

Adrenal insufficiency can be primary due to damage of the adrenal glands (referred to as Addison’s Disease).  It can also be secondary when there is pathology affecting the pituitary in the brain. There is emerging scientific evidence that there may be a subclinical form of Addison’s Disease, raising the question as to whether testing for Addison’s should be part of the differential diagnostic work up for a patient with fatigue.  In today’s broadcast we will explore these issues in greater detail.. .

Please forward us any comments here on our website or go to our Power Health Facebook page http://powerhealthreno.com/Facebook
References:
1. Sub-clinical addison’s disease.
Baruah MP.
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S176-7. doi: 10.4103/2230-8210.104033.
PMID: 23565372 [PubMed] Free PMC Article
Similar articles
2. I. Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: markers of low progression to clinical Addison’s disease.
Betterle C, Volpato M, Rees Smith B, Furmaniak J, Chen S, Greggio NA, Sanzari M, Tedesco F, Pedini B, Boscaro M, Presotto F.
J Clin Endocrinol Metab. 1997 Mar;82(3):932-8.
PMID: 9062509 [PubMed – indexed for MEDLINE]
Similar articles
3. Diagnosis and classification of Addison’s disease (autoimmune adrenalitis).
Brandão Neto RA, de Carvalho JF.
Autoimmun Rev. 2014 Apr-May;13(4-5):408-11. doi: 10.1016/j.autrev.2014.01.025. Epub 2014 Jan 11. Review.
PMID: 24424183 [PubMed – indexed for MEDLINE]
Similar articles
4. Estimated risk for developing autoimmune Addison’s disease in patients with adrenal cortex autoantibodies.
Coco G, Dal Pra C, Presotto F, Albergoni MP, Canova C, Pedini B, Zanchetta R, Chen S, Furmaniak J, Rees Smith B, Mantero F, Betterle C.
J Clin Endocrinol Metab. 2006 May;91(5):1637-45. Epub 2006 Mar 7.
PMID: 16522688 [PubMed – indexed for MEDLINE]
Similar articles
5. Adrenal cortex autoantibodies in subjects with normal adrenal function.
Betterle C, Coco G, Zanchetta R.
Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):85-99. Review.
PMID: 15826924 [PubMed – indexed for MEDLINE]
Similar articles
6. Autoimmune Addison’s disease.
Betterle C, Morlin L.
Endocr Dev. 2011;20:161-72. doi: 10.1159/000321239. Epub 2010 Dec 16. Review.
PMID: 21164269 [PubMed – indexed for MEDLINE]
Similar articles
7. An Addison disease revealed with a serious hyponatremia.
Maguet H, Carreau A, Hautefeuille S, Bonnin P, Beaune G.
Ann Biol Clin (Paris). 2017 Feb 1;75(1):87-91. doi: 10.1684/abc.2016.1212.
PMID: 28132947 [PubMed – indexed for MEDLINE]
Similar articles
8. Is Adrenal Insufficiency a Rare Disease?
Dahlqvist P, Isaksson M, Bensing S.
Front Horm Res. 2016;46:106-14. doi: 10.1159/000443870. Epub 2016 May 17.
PMID: 27210825 [PubMed – in process]
Similar articles
9. The unresolved riddle of glucocorticoid withdrawal.
Guerrero Pérez F, Marengo AP, Villabona Artero C.
J Endocrinol Invest. 2017 May 20. doi: 10.1007/s40618-017-0691-1. [Epub ahead of print] Review.
PMID: 28528436 [PubMed – as supplied by publisher]
Similar articles
10. [Adrenalitis].
Saeger W.
Pathologe. 2016 May;37(3):238-44. doi: 10.1007/s00292-016-0163-y. German.
PMID: 27099224 [PubMed – in process]
Similar articles
11. Ipilimumab-induced autoimmune adrenalitis.
Min L, Ibrahim N.
Lancet Diabetes Endocrinol. 2013 Nov;1(3):e15. doi: 10.1016/S2213-8587(13)70031-7. Epub 2013 Jul 9. No abstract available.
PMID: 24622375 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
12. Altered chemokine Th1/Th2 balance in Addison’s disease: relationship with hydrocortisone dosing and quality of life.
Ekman B, Alstrand N, Bachrach-Lindström M, Jenmalm MC, Wahlberg J.
Horm Metab Res. 2014 Jan;46(1):48-53. doi: 10.1055/s-0033-1351291. Epub 2013 Aug 5.
PMID: 23918683 [PubMed – indexed for MEDLINE]
Similar articles
13. An Unusual Presentation of Addison’s Disease-A Case Report.
Choudhary S, Alam A, Dewan V, Yadav D, Dubey NK.
Clin Pediatr Endocrinol. 2011 Jul;20(3):57-60. doi: 10.1297/cpe.20.57. Epub 2011 Oct 7.
PMID: 23926396 [PubMed] Free PMC Article
Similar articles
14. Mainly adrenal gland involving NK/T-cell nasal type lymphoma diagnosed with delay due to mimicking adrenal hemorrhage.
Kang SM, Kim WJ, Lee KA, Baek HS, Park TS, Jin HY.
J Korean Med Sci. 2011 Oct;26(10):1386-90. doi: 10.3346/jkms.2011.26.10.1386. Epub 2011 Oct 1.
PMID: 22022195 [PubMed – indexed for MEDLINE] Free PMC Article
Similar articles
15. [A clinical analysis of 21 cases of adrenal non-Hodgkin’s lymphoma].
Bu N, Wu H, Yao J, Zhang J, Gao Y, Guo X.
Zhonghua Nei Ke Za Zhi. 2015 Jan;54(1):22-6. Chinese.
PMID: 25877141 [PubMed – indexed for MEDLINE]
Similar articles
16. History of stress-related health changes: a cue to pursue a diagnosis of latent primary adrenal insufficiency.
Yamamoto T.
Intern Med. 2014;53(3):183-8.
PMID: 24492685 [PubMed – indexed for MEDLINE] Free Article
Similar articles
17. Addison’s disease: a survey on 633 patients in Padova.
Betterle C, Scarpa R, Garelli S, Morlin L, Lazzarotto F, Presotto F, Coco G, Masiero S, Parolo A, Albergoni MP, Favero R, Barollo S, Salvà M, Basso D, Chen S, Rees Smith B, Furmaniak J, Mantero F.
Eur J Endocrinol. 2013 Oct 21;169(6):773-84. doi: 10.1530/EJE-13-0528. Print 2013 Dec.
PMID: 24014553 [PubMed – indexed for MEDLINE] Free Article
Similar articles
18. GAD antibody-associated limbic encephalitis in a young woman with APECED.
Kopczak A, Schumacher AM, Nischwitz S, Kümpfel T, Stalla GK, Auer MK.
Endocrinol Diabetes Metab Case Rep. 2017 May 25;2017. pii: 17-0010. doi: 10.1530/EDM-17-0010. eCollection 2017.
PMID: 28567288 [PubMed – in process] Free PMC Article
Similar articles
19. A case of stiff-person syndrome due to secondary adrenal insufficiency.
Mizuno Y, Yamaguchi H, Uehara T, Yamashita K, Yamasaki R, Kira JI.
Rinsho Shinkeigaku. 2017 May 26. doi: 10.5692/clinicalneurol.cn-001008. [Epub ahead of print]
PMID: 28552871 [PubMed – as supplied by publisher]
Similar articles
20. Clinical features and practice patterns of treatment for adrenal crisis: a nationwide cross-sectional study in Japan.
Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, Tanaka Y.
Eur J Endocrinol. 2017 Mar;176(3):329-337. doi: 10.1530/EJE-16-0803.
PMID: 28130352 [PubMed – indexed for MEDLINE]
Similar articles

 

 

Leave a Comment

Your email address will not be published. Required fields are marked *

*