Do Heavy Metals Cause Autoimmune Disease?


In today’s discussion, we will go over some of the research regarding heavy-metal toxicity and autoimmune disease. This is a controversial topic and should be exciting.

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References:
1. Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.
Toomey CB, Cauvi DM, Hamel JC, Ramirez AE, Pollard KM.
Toxicol Sci. 2014 Dec;142(2):339-49. doi: 10.1093/toxsci/kfu189. Epub 2014 Sep 18.
PMID: 25237059 [PubMed – indexed for MEDLINE] Free PMC Article
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2. Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN.
Pollard KM, Escalante GM, Huang H, Haraldsson KM, Hultman P, Christy JM, Pawar RD, Mayeux JM, Gonzalez-Quintial R, Baccala R, Beutler B, Theofilopoulos AN, Kono DH.
J Immunol. 2017 Dec 1;199(11):3739-3747. doi: 10.4049/jimmunol.1700332. Epub 2017 Oct 20.
PMID: 29055005 [PubMed – indexed for MEDLINE]
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3. Blood levels of lead and mercury and celiac disease seropositivity: the US National Health and Nutrition Examination Survey.
Kamycheva E, Goto T, Camargo CA Jr.
Environ Sci Pollut Res Int. 2017 Mar;24(9):8385-8391. doi: 10.1007/s11356-017-8545-0. Epub 2017 Feb 9.
PMID: 28185175 [PubMed – indexed for MEDLINE]
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4. Mercury as an environmental stimulus in the development of autoimmunity – A systematic review.
Crowe W, Allsopp PJ, Watson GE, Magee PJ, Strain JJ, Armstrong DJ, Ball E, McSorley EM.
Autoimmun Rev. 2017 Jan;16(1):72-80. doi: 10.1016/j.autrev.2016.09.020. Epub 2016 Sep 23. Review.
PMID: 27666813 [PubMed – indexed for MEDLINE]
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2 Comments

  1. I love your information in these series. Thank you. I wondered if you have seen much MCS or T.I.L.T. in your practices.

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